| Description |
1 online resource (xi, 470 pages) : illustrations (chiefly color) |
| Series |
Advances in biochemistry in health and disease ; volume 22 |
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Advances in biochemistry in health and disease ; v. 22.
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| Contents |
Intro -- Preface -- Contents -- 1 Translating Nitric Oxide Research to Therapeutics: A Critical Appraisal -- Introduction -- NO Formation -- Factors Affecting NO Production -- Nitric Oxide Dynamics -- Sources of Nitric Oxide -- Therapeutic Potential of NO -- Conclusion -- References -- 2 Nitric Oxide and Cardiovascular Health -- Introduction -- Nitric Oxide Synthesis -- Regulation of Intracellular Levels of Nitric Oxide -- Cross-Talk Between Oxidative Stress and Nitrosative Stress -- Nitric Oxide Signaling -- Nitric Oxide and Cardiovascular Diseases -- Conclusions -- References |
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3 Nitric Oxide and Cardiovascular Diseases: Cardioprotection, Complications and Therapeutics -- Introduction -- Nitric Oxide (NO) and NO Synthases (NOS) -- Neuronal Nitric Oxide Synthase (nNOS) -- Inducible Nitric Oxide Synthase (iNOS) -- Endothelial Nitric Oxide Synthase (eNOS) -- NO Synthesis and Distribution -- NO and Vaso-Modulation -- The Link Between NO and Hydrogen Sulfide (H2S) Signaling -- Cardiovascular Homeostasis Maintenance by NO-NOS -- Homeostasis in Blood Vessels -- Homeostasis in Perivascular Adipose Tissue (PVAT) -- Homeostasis in Cardiac Myocytes |
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Homeostasis in Cardiovascular Nerve Cells -- NOS, NO and Cardiovascular Disease -- Endothelial Dysfunction -- NOS and NO in Cardiac Remodeling -- Contribution of NOS and NO in Common CVDs -- Hypertension -- Diabetes -- Heart Failure and Ventricular Hypertrophy -- Coronary Artery Disease (CAD) -- Atherosclerosis -- NO Signaling and Therapeutics and Pitfalls -- SGC Stimulators or Activators -- BH4 or Folate Supplementation -- Nitroxyl (HNO) -- Nitrate and Nitrite Supplementation -- PDE Inhibitors -- Experiences Form Clinical Studies -- Conclusion and Future Perspectives -- References |
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4 Nitric Oxide and the Heart Autonomic Nervous System -- Nitric Oxide in the Heart -- Nitric Oxide and Neuronal Nitric Oxide Synthase in the Intrinsic Cardiac Nervous System -- Role of Nitric Oxide as a Mediator of Cardiac Parasympathetic Effects -- Role of Nitric Oxide as a Modulator of Cardiac Sympathetic Effects -- NO as a Mediator in Autonomic Regulation of the Cardiac Conduction System -- NO as a Mediator in Autonomic Regulation of Coronary Flow -- Conclusion -- References -- 5 Exercise Induced NO Modulation in Prevention and Treatment of Cardiovascular Diseases -- Nitric Oxide and Exercise |
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Nitric Oxide Synthases -- Nitric Oxide-Mechanism of Action -- Nitric Oxide and Cardiovascular System -- Erythrocyte Derived NO and Exercise -- Neuronal Nitric Oxide Synthase in Cardiovascular System and Physical Activity -- NO, Exercise and Cardiovascular Diseases -- Hypertension -- Atherosclerosis, Coronary Artery Disease, Stroke -- Heart Failure -- Concluding Remarks -- References -- 6 Nitric Oxide-cGMP-PKG Signaling in the Cardioprotective Effects of Phosphodiesterase 5 Inhibitors -- Introduction -- Nitric Oxide (NO)-A Key Signaling Molecule in Cardioprotection |
| Summary |
This book entitled "Nitric Oxide: From Research to Therapeutics" includes the most recent information about the role of Nitric Oxide (NO) in physiology, pathophysiology and its translation to therapeutics. The Editors are vastly experienced in the field of NO research. The international panels of contributors to the various chapters of the book are all well-established researchers and health professionals who have worked in different areas of NO physiology and pathophysiology, and have made a considerable impact in the field. The book is a comprehensive collection of the most recent information on NO as a physiological regulator and its diverse potential as a therapeutic target for the treatment for a variety of disease states. This compilation is aimed at professionals and students from both academia and the industry in the areas of basic biomedical and clinical sciences |
| Bibliography |
Includes bibliographical references |
| Notes |
Online resource; title from PDF title page (SpringerLink, viewed March 16, 2023) |
| Subject |
Nitric oxide.
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Nitric oxide
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| Form |
Electronic book
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| Author |
Ray, Arunabha, editor.
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Gulati, Kavita, editor.
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| ISBN |
3031247787 |
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9783031247781 |
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