Title Statistical human genetics : methods and protocols / edited by Robert C. Elston, Jaya M. Satagopan, Shuying Sun

Published New York : Humana Press, ©2012

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Description 1 online resource (xi, 564 pages) : illustrations Series Methods in molecular biology, 1064-3745 ; 850 Methods in molecular biology (Clifton, N.J.) ; v. 850. 1064-3745 Contents Genetic terminology / Robert C. Elston, Jaya M. Satagopan, and Shuying Sun -- Identification of genotype errors / Yin Y Shugart and Ying Wang -- Detecting pedigree relationship errors / Lei Sun -- Identifying cryptic relationships / Lei Sun and Apostolos Dimitromanolakis -- Estimating allele frequencies / Indra Adrianto and Courtney Montgomery -- Testing departure from hardy-weinberg proportions / Jian Wang and Sanjay Shete -- Estimating disequilibrium coefficients / Maren Vens and Andreas Ziegler -- Detecting familial aggregation / Adam C. Naj, Yo Son Park, and Terri H. Beaty -- Estimating heritability from twin studies / Karin J.H. Verweij [and others] -- Estimating heritability from nuclear family and pedigree data / Murielle Bochud -- Correcting for ascertainment / Warren Ewens and Robert C. Elston -- Segregation analysis using the unified model / Xiangqing Sun -- Design considerations for genetic linkage and association studies / Jeremie Nsengimana and D. Timothy Bishop -- Model-based linkage analysis of a quantitative trait / Audrey H. Schnell and Xiangqing Sun -- Model-based linkage analysis of a binary trait / Rita M. Cantor -- Model-free linkage analysis of a quantitative trait / Nathan J. Morris and Catherine M. Stein -- Model-free linkage analysis of a binary trait / Wei Xu [and others] -- Single marker association analysis for unrelated samples / Gang Zheng [and others] -- Single-marker family-based association analysis condiational on parental information / Ren-Hua Chung and Eden R. Martin -- Single marker family-based association analysis not conditional on parental information / Junghyun Namkung -- Allowing for population stratification in association analysis / Huaizhen Qin and Xiaofeng Zhu -- Haplotype inference / Xin Li and Jing Li -- Multi-SNP haplotype analysis methods for association analysis / Daniel O. Stram and Venkatraman E. Seshan -- Detecting rare variants / Tao Feng and Xiaofeng Zhu -- Analysis of ethnic mixtures / Xiaofeng Zhu --= Identifying gene interaction networks / Gurkan Bebek -- Structural equation modeling / Catherine M. Stein, Nathan J. Morris, and Nora L. Nock -- Genotype calling for the affymetrix platform / Arne Schillert and Andreas Ziegler -- Genotype calling for the illumina platform / Yik Ying Teo -- Comparison of requirements and capabilities of major multipurpose software packages / Robert P. Igo Jr. and Audrey H. Schnell Summary Recent advances in genetics over the last quarter of a century, especially in molecular techniques, have dramatically reduced the cost of determining genetic markers and hence opened up a field of research that is increasingly helping to detect, prevent and/or cure many diseases that afflict humans. In Statistical Human Genetics: Methods and Protocols expert researchers in the field describe statistical methods and computer programs in the detail necessary to make them more easily accessible to the beginner analyzing data. Written in the highly successful Methods in Molecular Biology series format, with examples of running the programs and interpreting the program outputs, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results from human genetic data collected in the laboratory. Thorough and as much as possible intuitive, Statistical Human Genetics: Methods and Protocols aids scientists in understanding the computer programs and analytical procedures they need to use Analysis Life sciences Human genetics Statistical methods Animal genetics Animal Genetics and Genomics Biostatistics humane genetica genomica genomics diergenetica biostatistiek Genetics (General) Genetica (algemeen) Notes Includes index Bibliography Includes bibliographical references and index Notes English Subject Human genetics -- Statistical methods Biochemical markers. Statistics. Decision making -- Mathematical models. Nucleic acid hybridization. Phenotype. Genetics -- Technique. Medical informatics. Medicine -- Data processing. Medical personnel. Biology. Biologicals. Biological products. Life sciences. Public health. Physical sciences. Medical care. Medical genetics. Genetic markers. Genetics Medicine Sequence Analysis Microarray Analysis Biomarkers Statistics as Topic Decision Support Techniques Molecular Probe Techniques Nucleic Acid Hybridization Phenotype Genetic Techniques Microchip Analytical Procedures Epidemiologic Methods Investigative Techniques Medical Informatics Applications Genetic Phenomena Health Occupations Health Care Evaluation Mechanisms Biology Biological Factors Chemicals and Drugs Analytical, Diagnostic and Therapeutic Techniques and Equipment Medical Informatics Disciplines and Occupations Phenomena and Processes Biological Science Disciplines Chemistry Techniques, Analytical Quality of Health Care Public Health Environment and Public Health Information Science Natural Science Disciplines Health Care Quality, Access, and Evaluation Delivery of Health Care Genetics, Medical Oligonucleotide Array Sequence Analysis Data Interpretation, Statistical Genetic Markers Health Workforce Health Personnel Biological Products Patient Care biology. biological sciences. public health. physical sciences. statistics. Statistics Public health Physical sciences Phenotype Nucleic acid hybridization Medicine -- Data processing Medical personnel Medical informatics Medical genetics Medical care Life sciences Genetics -- Technique Genetic markers Decision making -- Mathematical models Biology Biologicals Biological products Biochemical markers Human genetics -- Statistical methods Genre/Form Laboratory manuals. Manuels de laboratoire. Form Electronic book Author Elston, Robert C Satagopan, Jaya M Sun, Shuying ISBN 9781617795558 1617795550 1617795542 9781617795541

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