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Book Cover

Title Somatic cell nuclear transfer / edited by Peter Sutovsky
Published New York : Springer Science+Business Media ; Austin, Tex. : Landes Bioscience/, ©2007


Description 1 online resource (xv, 135 pages) : illustrations
Series Advances in experimental medicine and biology ; v. 591
Advances in experimental medicine and biology ; v. 591.
Contents Nuclear remodeling and nuclear reprogramming for making transgenic pigs by nuclear transfer / Randall S. Prather -- Somatic cell nuclei in cloning : strangers traveling in a foreign land / Keith E. Latham, Shaorong Gao, and Zhiming Han -- Cloning cattle : the methods in the madness / Bjørn Oback and David N. Wells -- Centrosome inheritance after fertilization and nuclear transfer in mammals / Qing-Yuan Sun and Heide Schatten -- Developmental, behavioral, and physiological phenotype of cloned mice / Kellie L.K. Tamashiro [and others] -- Nucleolar remodeling in nuclear transfer embryos / Jozef Laurincik and Poul Maddox-Hyttel -- Somatic cell nuclear transfer (SCNT) in mammals : the cytoplast and its reprogramming activities / Josef Fulka, Jr. and Helena Fulka -- Mitochondrial DNA inheritance after SCNT / Stefan Hiendleder -- Activation of fertilized and nuclear transfer eggs / Christopher Malcuit and Rafael A. Fissore
Summary When I was first approached to edit the present volume, I was somewhat relucƯ tant to undertake this humbling task because most of my own scientific expertise is derived fi'om studies of mammalian fertilization rather than somatic cell nuclear transfer (SCNT). However, in the last ten years, I was very fortunate to train, colƯ laborate, and communicate with a number of distinguished "doners," many of whom kindly agreed to contribute to the present volume. This experience made me appreƯ ciate that the understanding of cellular and molecular events during and after SCNT is deeply rooted in our knowledge of fertilization of mammalian ovum by the speramatozoon, to which I prefer to refer to as "natural fertilization," not to say that SCNT should be regarded as "unnatural fertilization". Unique cellular events arisƯ ing from SCNT have no parallel in natural fertilization and early pre-implantation development. The list includes the requirement of donor cell-nuclear remodeling, disposal of donor cell organelles, the possibility of heteroplasmy (i. e., presence of mixed mitochondrial genomes) and altered mode of oocyte activation. Thanks to seminal contributions of my distinguished colleagues, the present volume reviews the progress of SCNT technology in major mammalian species including mouse, pig, and cattle, while at the same time, parallels can be drawn and distinctions made between the cellular and molecular basis of nuclear transfer and fertilization
Analysis biochemie
cellular biology
Cellular Biology
Bibliography Includes bibliographical references and index
Notes Print version record
In Springer eBooks
Subject Cloning.
Cell nuclei -- Transplantation.
Somatic cells.
Cloning, Organism -- methods
Cloning, Organism
Cloning, Molecular -- methods
Gene Transfer Techniques
SCIENCE -- Biotechnology.
Cell nuclei -- Transplantation.
Somatic cells.
Cloning, Organism -- methods.
Cloning, Molecular -- methods.
Gene Transfer Techniques.
Noyau (Cellule) -- Greffe.
Cellules somatiques.
Sciences de la vie.
Cell nuclei -- Transplantation
Somatic cells
Form Electronic book
Author Sutovsky, Peter.
ISBN 9780387377544