| Description |
1 online resource (xiv, 501 pages) |
| Series |
Oxford series in behavioral neuroendocrinology |
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Oxford series in behavioral neuroendocrinology.
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| Contents |
Acknowledgments -- Contributors -- Introduction to Estrogens and Memory: Basic Research and Clinical Implications -- PART I -- 1. Estrogen Receptor Distribution in the Hippocampus and Prefrontal Cortex -- 2. Estrogen Receptors at the Membrane: Interactions with Metabotropic Glutamate Receptors and Caveolin Proteins Regulated Through Palmitoylation -- 3. Rapid Effects of Estradiol on Dendritic Spines and Synaptic Plasticity in the Male and Female Hippocampus -- 4. Rapid Modulation of Spinogenesis by Estradiol in the Neocortex: An Emerging Role for GPER? -- 5. Estrogenic Regulation of Synaptic Actin Proteins and Plasticity -- 6. Hippocampal Synaptic Stability and Plasticity: The Role of Hippocampus-Derived Estradiol -- 7. Estrogenic Regulation of Glia and Neuroinflammation -- PART II -- 8. Molecular Mechanisms Underlying Rapid Effects of Estradiol on Memory Consolidation -- 9. Estrogenic Regulation of Spatial Memory in Songbirds -- 10. Estrogenic Regulation of Recognition Memory and Spinogenesis -- 11. Who Are You and What Do You Know? Estrogenic Regulation of Social Recognition and Social Learning -- 12. Estrogens Have Their Ups and Downs: A Multiple Memory Systems Approach to the Bidirectional Effects of Estrogens on Learning Strategy -- 13. Puberty: Effects on the Prefrontal Cortex and Cognitive Behavior -- 14. Ovarian Hormones, Cognition, and Reproductive Aging: Applications and Implications for Translating Preclinical Endocrine Brain Research to the Clinic -- 15. Estrogenic Regulation of Hippocampal Neurogenesis Throughout the Lifespan -- 16. Effects of Estradiol on Basal Forebrain Cholinergic Neurons and Their Impact on Cognitive Performance and Age-Related Cognitive Decline -- 17. Estrogenic Regulation of Synaptic Health and Cognition in Aging Rhesus Monkeys -- PART III -- 18. Hormone Therapy in Postmenopausal Women: The Women's Health Initiative and Its Continuing Impact on Research and Practice -- 19. Estrogen Treatment in Alzheimer's Disease: Translational Implications of Estrogenic Regulation of Memory for Aging and Disease -- 20. Effects of Dietary Estrogens on Dementia -- 21. Oral Contraceptive Effects on Cognition -- 22. Considerations on the Use of Aromatase Inhibitors in Postmenopausal Women With Breast Cancer: Cognitive Function -- 23. Estrogen Neuroprotection and Anti-Inflammation Actions in the Hippocampus -- 24. Estrogenic Regulation of Neuroprotection and Inflammation in Ischemic Stroke and Aging -- 25. Estradiol and Sex Differences in Generalized Fear: Implications for Anxiety Disorders -- 26. Role of Estrogens in Addiction-Related Learning -- PART IV -- 27. Moving Forward: A Vision for -- Future Research on Estrogenic Regulation of Memory -- Index |
| Summary |
"A book about the influence of estrogens on memory would have been unthinkable as recently as 30 years ago. Although a few small studies in the late 1970's reported a beneficial effect of estrogens on memory in human women (Hackman and Galbraith, 1976; Fedor-Freybergh, 1977), examination of the role of estrogens in memory did not truly capture more widespread attention until the pioneering work of Barbara Sherwin and colleagues in 1988 and beyond. In her initial paper, Sherwin showed that bilateral removal of the ovaries (aka surgical menopause) led to impaired short-term and long-term memory, whereas treatment of surgically menopausal women with estradiol alone, testosterone alone, or estradiol plus testosterone prevented this decline (Sherwin, 1988). As a search for the terms "estrogen" and "memory" in PubMed illustrates, well over 2000 papers have been published on the subject of estrogens and memory in the ensuing decades. The vast majority of these studies have focused on the hippocampus, a bilateral medial temporal lobe structure essential for the formation of episodic memories, particularly those with spatial, contextual, relational, temporal, and recognition components (Olton et al., 1979; Morris et al., 1982; Kim and Fanselow, 1992; Squire, 1992; Cohen and Stackman, 2015; Tonegawa et al., 2015; Eichenbaum, 2017). Although various forms of learning and memory are mediated by numerous brain regions, including the prefrontal cortex, medial temporal lobe cortices, amygdala, striatum, and cerebellum, the hippocampus has received the lion's share of attention due to its central importance for episodic memory formation. Hippocampal damage produces profound retrograde amnesia for facts and events, as well as anterograde amnesia for new information and impairments in spatial navigation (Winocur, 1990; Anagnostaras et al., 2001; Clark et al., 2002; Gilboa et al., 2006). Hippocampal dysfunction in middle-aged and aged subjects is a primary contributor to age-related memory decline (Golumb et al., 1996; Grady et al., 2003; Apostolova et al., 2010; Burke and Barnes, 2010; Small et al., 2011; Yassa et al., 2011), and has also been implicated in the cognitive impairments observed in diseases such as schizophrenia and depression (Small et al., 2011; Nakahara et al., 2018; Santos et al., 2018; Ott et al., 2019). Moreover, the hippocampi of patients with Alzheimer's disease are substantially atrophied and burdened with copious amounts of amyloid plaques and neurofibrillary tangles, the hallmark pathologies of this insidious disease (Hyman et al., 1984; Walsh and Selkoe, 2004; Selkoe and Hardy, 2016). As such, understanding how estrogens influence hippocampal functioning may provide important insights not only about the fundamental neurobiology of memory processes, but also into the etiology of neuropsychiatric and neurodegenerative diseases"-- Provided by publisher |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Description based on online resource; title from digital title page (viewed on February 28, 2020) |
| Subject |
Estrogen -- Physiological effect
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Cognition disorders -- Endocrine aspects
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Estrogen -- Therapeutic use.
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Estrogen Replacement Therapy
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Estrogen -- Physiological effect
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Estrogen -- Therapeutic use
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| Form |
Electronic book
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| Author |
Frick, Karyn M., editor.
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| LC no. |
2019035598 |
| ISBN |
9780190645922 |
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019064592X |
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9780190645915 |
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0190645911 |
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0190669101 |
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9780190669102 |
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