| Description |
1 online resource (198 pages) |
| Series |
CRC Revivals |
| Contents |
Cover Page; Title Page; Copyright Page; Table of Contents; Preface; Acknowledgment; The Author; Chapter 1 Introduction; References; Chapter 2 Reversible Zymo-Hydrolysis -- A Chronology of Enzymatic Peptide Synthesis; References; Chapter 3 Thermodynamic Aspects of Peptide Bond Synthesis; References; Chapter 4 Formation of Peptide Bonds -- Proteases as Activating Systems; References; Chapter 5 Proteosynthesis vs. Proteolysis: How to Bias This Antagonism in Favor of Proteosynthesis; I. Shift of Ionic Equilibria; A. Cancelling the Zwitterionic Character of the Reactants |
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B. Effects of Organic Co-SolventsC. Variation of Temperature and pH; D. Influence of the Chain Length of the Reactants; II. Shift of Chemical Equilibria; A. Solubility-Controlled Synthesis; B. Molecular Traps; C. Effects of Concentration; D. Temperature-Dependent Equilibrium Shifts; III. Nonequilibrium Approaches: Kinetically Controlled Synthesis; IV. Some Additional Considerations Due to the Proteases Themselves; References; Chapter 6 Advantages of Enzymatic Peptide Synthesis; I. Specificity; A. Structural Specificity; B. Regiospecificity; C. Stereospecificity |
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II. Other Positive Aspects of Enzymatic Peptide SynthesisReferences; Chapter 7 Proteases as Biocatalysts for the Synthesis of Model Peptides; I. Introduction; II. α-Chymotrypsin; III. Trypsin; IV. Subtilisin BPNâ#x80;#x99;; V. Elastase; VI. Thermitase; VII. Carboxypeptidase Y (CPD-Y); VIII. Papain; IX. Pepsin; X. Thermolysin; References; Chapter 8 Enzymatic Synthesis of Biologically Active Peptides; I. Introduction; II. Endogenous Opiate Peptides; III. Cholecystokinin and Related Peptides; IV. Melanotropin-, Eledoisin-, And â#x80;#x9C;Epidermal Growth Factorâ#x80;#x9D; Fragments |
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V. Proteases as Biocatalysts for the Synthesis of Biologically Active Peptidesâ#x80;#x94;A Summary to DateReferences; Chapter 9 Protease-Catalyzed Oligomerization; References; Chapter 10 Protease-Catalyzed Semisynthesis; I. Introduction; II. Insulin; III. Protease Inhibitors; IV. Nucleases; V. Miscellaneous; References; Chapter 11 Kinetics of Protease-Controlled Synthesis of Peptide Bonds; References; Chapter 12 Proteases as Catalysts in Protecting Group Chemistry; I. Introduction; II. Nα-Protecting Groups; III. α-Carboxyl Protection; IV. Enzyme-Sensitive Side-Chain Protection; References |
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Chapter 13 Shortcomings and AlternativesReferences; Chapter 14 Synopsis and Prognosis; References; Abbreviations; Index |
| Bibliography |
Includes bibliographical references at the end of each chapters and index |
| Notes |
Print version record |
| Subject |
Proteolytic enzymes.
|
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Proteins -- Synthesis.
|
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Peptide Hydrolases
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Protein Biosynthesis
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Proteins -- Synthesis
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Proteolytic enzymes
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| Form |
Electronic book
|
| ISBN |
9781351088732 |
|
1351088734 |
|
9781351071833 |
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1351071831 |
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