| Description |
1 online resource (xx, 194 pages) : illustrations |
| Series |
Advances in experimental medicine and biology ; no. 725 |
|
Advances in experimental medicine and biology ; no. 725. 0065-2598
|
| Contents |
Fuzzy complexes : a more stochastic view of protein function / Monika Fuxreiter and Peter Tompa -- Dynamic fuzziness during linker histone action / Steven J. McBryant and Jeffrey C. Hansen -- Intrinsic protein flexibility in regulation of cell proliferation : advantages for signaling and opportunities for novel therapeutics / Ariele Viacava Follis, Charles A. Galea, and Richard W. Kriwacki -- Interplay between protein order, disorder and oligomericity in receptor signaling / Alexander B. Sigalov -- Consequences of fuzziness in the NFB/IB interaction / Elizabeth A. Komives -- Roles for intrinsic disorder and ̂fuzziness in generating context specific function in ultrabithorax : a hox transcription factor / Sarah E. Bondos and Hao Ching Hsiao -- Molecular recognition by the EWS transcriptional activation domain / Kevin A.W. Lee -- The measles virus NTAILXD complex : an illustrative example of fuzziness / Sonia Longhi -- Fuzziness in the core of the human pathogenic viruses HCV and HIV / Roland Ivanyi Nagy and Jean Luc Darlix -- Structural disorder and protein elasticity / Sarah Rauscher and Røgis Pomès |
| Summary |
Detailed characterization of fuzzy interactions will be of central importance for understanding the diverse biological functions of intrinsically disordered proteins in complex eukaryotic signaling networks. In this volume, Peter Tompa and Monika Fuxreiter have assembled a series of papers that address the issue of fuzziness in molecular interactions. These papers provide a broad overview of the phenomenon of fuzziness and provide compelling examples of the central role played by fuzzy interactions in regulation of cellular signaling processes and in viral infectivity. These contributions summarize the current state of knowledge in this new field and will undoubtedly stimulate future research that will further advance our understanding of fuzziness and its role in biomolecular interactions |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| Subject |
Proteins -- Conformation.
|
|
Protein folding.
|
|
Protein binding.
|
|
Fuzzy systems.
|
|
Proteins -- Denaturation.
|
|
Protein Conformation
|
|
Protein Denaturation
|
|
Protein Binding
|
|
SCIENCE -- Life Sciences -- Biochemistry.
|
|
Proteins -- Denaturation
|
|
Fuzzy systems
|
|
Protein binding
|
|
Protein folding
|
|
Proteins -- Conformation
|
| Form |
Electronic book
|
| Author |
Fuxreiter, Monika, 1969-
|
|
Tompa, Peter
|
| ISBN |
9781461406594 |
|
1461406595 |
|
