| Description |
1 online resource (197 pages) : illustrations |
| Contents |
Contributors; Current books of interest; Preface; 1: Serum Proteomics for Studying Disease Pathogenesis and Identification of Disease Biomarkers; Introduction; Challenges of serum proteome analysis; Proteomic techniques in serum profiling; Applications; Conclusion; 2: Serum Profiling by Targeted Proteomics for Biomarker Discovery; Biomarker discovery; Targeted proteomics; Serum profiling by targeted proteomics; Conclusions; 3: Targeted Proteomics: Applications in the Study of Liver Disorders; The liver; Shotgun proteomics and liver disorders |
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MS-based targeted proteomics: selected reaction monitoring for protein detection and quantitationProtein regulation: targeted analysis of post-translational modifications based on enrichment procedures; Concluding remarks and future perspectives; 4: Targeted Proteomics for Chronic Lymphocytic Leukaemia; Introduction; Epidemiology and incidence; Clinical presentation; Monoclonal B lymphocytosis (MBL); Genetic and epigenetic analysis of CLL; Proteomics profiles in B-cell malignancies; Proteome analysis of B-cell maturation; Quantitative proteomics |
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'Shot gun' proteomic studies on B-cell malignanciesConclusions and future directions; 5: Protein Microarrays: A Versatile Tool for Scientific Discovery; Introduction; Basic research applications; Clinical research applications; Data analysis and bioinformatics; Outlook and perspective; 6: Bioinformatics Challenges in Targeted Proteomics; Introduction; Experimental design; Data acquisition and data processing; Noise reduction and normalization; Data interpretation |
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7: Standardized Formats, Report Information Guidelines, Mass Spectrometry-based Repositories and Application Programming Interfaces for Implementing Data Standards in ProteomicsBackground: HUPO-PSI; Standardization pillars: MIAPE guidelines, XML-based standard formats and controlled vocabularies; Proteomics repositories and databases; Application Programming Interfaces (APIs) for the integration of data standards into laboratory pipelines; Bioinformatics tools for creating and managing proteomics data standards; Data analysis and reporting tools; Conclusions |
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8: Clinical Protein Science and Targeted Mass Spectrometric Assays -- New Frontiers in Disease Link and BiobankingThe unmet needs and progresses in modern healthcare; Building new medical frontiers in modern society; Impact to society of personalized medicines; Biobanking; Protein biomarkers and targeted analysis; Prostate cancer protein biomarker analysis; Conclusions; Index |
| Summary |
Targeted proteomics is a technology for detecting proteins of interest with high sensitivity, quantitative accuracy, and reproducibility. The analysis of a pre-defined group of proteins provides precise, quantitative, and sensitive data to scientists and clinicians and can provide information on a subset of proteins important for their biological function. In this volume, a panel of high-profile contributors provides an overview of targeted proteomics in biomedical science. The book is focused on current state-of-the-art technology and applications, and it will be a valuable source of informat |
| Bibliography |
Includes bibliographical references at the end of each chapters and index |
| Notes |
Online resource; title from PDF title page (ebrary, viewed July 17, 2014) |
| Subject |
Proteomics.
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Proteins -- Structure
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Protein binding.
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Gene expression.
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Post-translational modification.
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Proteomics
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Protein Binding
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Gene Expression
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SCIENCE -- Life Sciences -- Biochemistry.
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Gene expression
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Post-translational modification
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Protein binding
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Proteins -- Structure
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Proteomics
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| Form |
Electronic book
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| Author |
Fuentes, Manuel, editor.
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LaBaer, Joshua, editor.
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| LC no. |
2014451624 |
| ISBN |
9781908230621 |
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1908230622 |
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1908230460 |
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9781908230461 |
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