| Description |
1 online resource (327 pages) |
| Contents |
Cover -- Title Page -- Copyright Page -- TABLE OF CONTENTS -- SECTION 1: GENERAL CONCEPTS -- Chapter 1: The Classical Concepts of the Origin and Development of Malignant Tumors -- Chapter 2: Control of Gene Expression during Cell Cycle and Growth of Mammalian Cells -- Chapter 3: Transit, Exit, and Arrest Models for Control of the Mammalian Cell Cycle -- Chapter 4: Cancer-A Disease of Tissue Neogenesis? -- Chapter 5: Neoplasia and the Wound Response: The Lesson Learned from the Multistage Approach of Skin Carcinogenesis -- SECTION 2: CELL TRANSFORMATION -- Chapter 1: The Role of Polypeptide Growth Factors in Phenotypic Transformation of Normal Cells -- Chapter 2: Density-Development Control of Cell Proliferation: Molecular Mechanisms Involved in Contact-Inhibition -- Chapter 3: Cancer as a Mutation-Driven Evolutionary Process -- Chapter 4: Mutation-Driven Evolution of Rev-T -- Chapter 5: Expression of ras, myc, and erb-A Proto-Oncogenes in Preneoplastic Rat Liver during Chemical Carcinogenesis -- Chapter 6: Oncogene Expression in Preneoplastic and Neoplastic Lesions -- Chapter 7: Timing of Proto-Oncogene Replication and its Relationship to Transformation Sensitivity to Chemical Carcinogens -- Chapter 8: The Roles of Cell Proliferation and Gene Replication in Neoplastic Transformation -- Chapter 9: Oncogene Amplification: myc and neu Oncoproteins -- Chapter 10: Structure, Expression, and Oncogenic Activity of the myc Gene Family -- Chapter 11: The myc Family of Nuclear Oncoproteins: Structure, Biochemistry, and Activities -- SECTION 3: FROM FACTOR DEPENDENCE TO FACTOR INDEPENDENCE -- Chapter 1: Critical Variables for the Oncogene-Induced Immortalization of Fischer Rat Embryo Cells -- Chapter 2: Biological Aspects of the Process -- Chapter 3: Immortalization of Cultured Mammalian Cells: A brief Review of the Recent Literature |
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Chapter 4: Transfer of an Extrachromosomal, Cytoplasmic Mouse DNA Leads to Immortalization of Human Lymphocytes without Induction of the Tumorigenic Phenotype -- Chapter 5: Growth Regulation in Normal and Malignant Melanocytes -- Chapter 6: Paracrine Interactions Govern the Progression of Lympho-hemopoietic Malignancies: Evidence from Long-Term Marrow Cultures -- Chapter 7: ras Oncogene Mediates Paracrine Interactions between Leukemic Progenitor Cells and Stromal Elements -- Chapter 8: Role of Oncogenes in the Abrogation of Growth Factor Requirements of Hemopoietic Cells -- Index |
| Summary |
Growth Regulation and Carcinogenesis discusses topics such as growth factors, including stimulators and inhibitors of proliferation; networks in proliferation regulation; differentiation-inducing factors; origins of neoplasia and their relationship to growth control; genetic alterations in cellular regulatory machinery; extrachromosomal phenomena; non-genotoxic carcinogens; immortalization and transformation of cells; and the role of cell production, cell function, and cell elimination in physiological growth control |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| Subject |
Cells -- Growth -- Regulation.
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Cancer cells -- Growth -- Regulation.
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Growth factors.
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Carcinogenesis.
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Growth Substances
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Carcinogenesis
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HEALTH & FITNESS -- Diseases -- General.
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MEDICAL -- Clinical Medicine.
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MEDICAL -- Diseases.
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MEDICAL -- Evidence-Based Medicine.
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MEDICAL -- Internal Medicine.
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Cancer cells -- Growth -- Regulation
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Carcinogenesis
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Cells -- Growth -- Regulation
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Growth factors
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| Form |
Electronic book
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| ISBN |
9781351080774 |
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1351080776 |
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9781351072328 |
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1351072323 |
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