| Description |
1 online resource |
| Series |
CRC Press Revivals |
| Contents |
Cover; Half Title; Title Page; Copyright Page; Contents; Chapter 1 Regulation of Cell Functions; I. Introduction; II. The Cell Cycle; A. Phases of the Cell Cycle; B. Regulation of the Cell Cycle; C. Cellular Senescence; D. Apoptosis; E. Cellular Immortalization; III. Regulation of Cell Proliferation and Differentiation; A. Role of Growth Factors in Developmental Processes; B. Regulation of Homeobox-Containing Genes; C. Competence and Progression Factors; D. Cellular Responses to Growth Factors; E. Regulation of Differentiated Functions by Growth Factors; F. Growth Factor-Like Proteins |
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G. Proliferation-Associated Cellular ProteinsH. Mechanisms of Regulation of Cell Proliferation by Growth Factors; 1. Gene Expression During the Cell Cycle; 2. Cyclins; 3. The cdc2 and cdk2 Protein Kinases; 4. Transcription Factors; 5. Heat Shock Proteins; I. Differentiation-Inducing Factors; 1. Osteogenin; 2. Preadipocyte-Stimulating Factor; 3. Leukemia-Related Differentiation Inducers; 4. Leukemia Inhibitory Factor; 5. Other Differentiation Inducers; 6. Mechanisms of Cell Differentiation; J. Differentiation-Inhibiting Factors; K. Growth-Inhibiting Factors; 1. GIFs Produced by Normal Cells |
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2. GIFs Produced by Neoplastic C ells3. Physiological Role of GIFs; 4. Role of GIFs in Oncogenesis; IV. Growth Factors as Mediators of Hormone Action; A. Growth Hormone; 1. The Growth Hormone Receptor; 2. Somatomedins; B. Thyroid Hormone; 1. Thyroid Hormone Receptors; 2. Growth Factors as Mediators of Thyroid Hormone Action; C. Steroid Hormones; 1. Steroid Hormone Receptors; 2. Growth Factors as Mediators of Steroid Hormone Action; References; Chapter 2 Growth Factor Receptors; I. Introduction; II. Growth Factor Receptors; A. Regulation of Receptor Expression; B. Receptor Phosphorylation |
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C. Mobility and Internalization of Surface ReceptorsD. Receptor Expression in Neoplastic Cells; References; Chapter 3 Postreceptor Mechanisms of Growth Factor Action; I. Introduction; II. Mediators and Modulators of Growth Factor Action; A. Prostaglandins; 1. Physiological Role of Prostaglandins; 2. Cellular Mechanisms of Action of Prostaglandins; 3. Role of Prostaglandins in Tumors; B. Leukotrienes; C. Poly amines; 1. Regulation of Ornithine Decarboxylase; 2. Mechanisms of Action of Polyamines; 3. Role of Poly amines in Oncogenesis; III. Ion and pH Changes; A. Ion Fluxes and Cytoplasmic pH |
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B. Mechanism of Na[sub(+)]/H[sub(+)] Exchange RegulationC. Influence of Mitogens, Hormones, and Growth Factors; D. Regulation of Cell Cycle-Associated Events; E. Influence of Oncogenes; F. Expression of a Transformed Phenotype; G. Role of Magnesium; References; Chapter 4 Cyclic Nucleotides; I. Introduction; II. Cyclic AMP and the Adenylyl Cyclase System; A. The Adenylyl Cyclase System; 1. The Adenylyl Cyclase Family; 2. Regulation of the Adenylyl Cyclase System; 3. Role of cAMP in Hormone and Growth Factor Action; 4. Role of cAMP in the Regulation of Gene Expression |
| Summary |
Volume I of this book provides a comprehensive discussion of the factors involved in regulation of the cell cycle, the general biological properties of growth factors, and the receptor and postreceptor mechanisms of action of these signaling agents. It evaluates the possible role of growth factors in the regulation of proto-oncogene and tumor suppressor gene expression, and the development of neoplastic processes is discussed in detail |
| Subject |
Genetics.
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Endocrinology.
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Cytology.
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BIOSCIENCEnetBASE
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SCI-TECHnetBASE
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LIFESCIENCEnetBASE
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MEDICINEnetBASE
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STMnetBASE
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Growth factors.
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Genetics
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Endocrinology
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Cell Biology
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Growth Substances
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Cytology
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genetics.
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SCIENCE / Life Sciences / Genetics & Genomics
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MEDICAL / Endocrinology & Metabolism
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SCIENCE / Life Sciences / Cytology
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Cytology
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Endocrinology
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Genetics
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Growth factors
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| Form |
Electronic book
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| ISBN |
9780203712603 |
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0203712609 |
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9781351363181 |
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1351363182 |
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9781351363174 |
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1351363174 |
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9781351363167 |
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1351363166 |
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