| Description |
1 online resource (xi, 463 pages) : illustrations (some color) |
| Series |
Methods in Molecular Biology, 1064-3745 ; 1267 |
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Methods in molecular biology (Clifton, N.J.) ; v. 1267. 1064-3745
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| Contents |
Modeling cancer using genetically engineered mice / Patricia Stiedl ... [and 4 others] -- Lung adenocarcinomas : comparison between mice and men / Helmut H. Popper -- Mouse models of breast cancer / Kazuhito Sakamoto, Jeffrey W. Schmidt, and Kay-Uwe Wagner -- Genetically engineered mouse models to study prostate cancer / Elspeth A. Brzezinska ... [and 3 others] -- Practical use of advanced mouse models for lung cancer / Roghaiyeh Safari and Ralph Meuwissen -- Generation and analysis of mouse intestinal tumors and organoids harboring APC and K-Ras mutations / Johan H. van Es and Hans Clevers -- Induction of colorectal cancer in mice and histomorphometric evaluation of tumors / Ilija Crncec ... [and 3 others] -- Mouse models of liver cancer / Jorge Matias Caviglia and Robert F. Schwabe -- Current methods in mouse models of pancreatic cancer / Pawel K. Mazur ... [and 3 others] -- Mouse models of nonmelanoma skin cancer / Nicole Amberg ... [and 5 others] -- Clinicopathological characterization of mouse models of melanoma / Blake Ferguson, H. Peter Soyer, and Graeme J. Walker -- Modeling BCR/ABL-driven malignancies in the mouse / Christine Schneckenleithner, Andrea Hoelbl-Kovacic, and Veronika Sexl -- Methods to generate genetically engineered mouse models of soft tissue sarcoma / Rebecca D. Dodd ... [and 5 others] -- Characterization of mouse model-derived osteosarcoma (OS) cells in vitro and in vivo / Özge Uluçkan, Latifa Bakiri, and Erwin F. Wagner -- Genetically engineered mouse and orthotopic human tumor xenograft models of retinoblastoma / Claudia A. Benavente and Michael A. Dyer -- Tumor imaging technologies in mouse models / Michael Bouvet and Robert M. Hoffman -- Tumor angiogenesis : methods to analyze tumor vasculature and vessel normalization in mouse models of cancer / Federica Maione and Enrico Giraudo -- Transplantable mouse tumor models of breast cancer metastasis / Rumela Chakrabarti and Yibin Kang -- Methods to study primary tumor cells and residual tumor cells in mouse models of oncogene dependence / Caroline Botta ... [and 3 others] -- Generation of transgenic mouse model using PTTG as an oncogene / Sham S. Kakar and Cohin Kakar -- Modeling the study of DNA damage responses in mice / Julia Specks ... [and 3 others] -- Methods to study tumor surveillance using tumor cell transplantation into genetically engineered mice / Eva Bauer ... [and 3 others] |
| Summary |
This volume is essential for geneticists, molecular biologists, biochemists, and medical doctors interested in the use of mouse models in cancer research. Recent genome studies, together with refined genetic engineering techniques, have greatly increased the value of using mice for research on cancer and other human disorders. The chapters of this book will support scientists in choosing the most suitable mouse models for their research questions. The book provides detailed methodological information for genetic or chemical induction of different types of cancer, histomorphometric cancer analysis, and "in vivo" imaging, as well as protocols to investigate oncogene addiction, immune surveillance, and hallmarks of cancer such as angiogenesis or metastasis. Four review-like articles provide background information on mouse technologies and histopathologic differences between mouse and human cancers. The mouse models described in individual chapters will fuel the understanding of cancer initiation, immune system roles, tumor angiogenesis, invasion, metastasis, and the relevance of molecular diversity observed among human cancers. Written in the highly successful "Methods in Molecular Biology" series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and resourceful, "Mouse Models of Cancers: Methods and Protocols, " is a valuable laboratory resource for all researchers, from the graduate level upwards, who study cancer and new possibilities for its treatment." |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Online resource; title from PDF title page (SpringerLink, viewed February 9, 2015) |
| Subject |
Cancer -- Animal models.
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Mice as laboratory animals.
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Chordata.
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Diseases -- Animal models.
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Diseases.
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Mammals.
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Mice.
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Muridae.
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Cancer invasiveness.
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Metastasis.
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Oncology, Experimental.
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Vertebrates.
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Analytical, Diagnostic and Therapeutic Techniques and Equipment
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Animals
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Chordata
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Disease Models, Animal
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Disease
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Eukaryota
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Investigative Techniques
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Laboratory Manuals
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Mammals
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Mice
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Models, Animal
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Muridae
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Murinae
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Neoplasm Invasiveness
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Neoplasm Metastasis
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Neoplasms, Experimental
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Neoplasms
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Neoplastic Processes
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Organisms
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Pathologic Processes
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Pathological Conditions, Signs and Symptoms
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Publication Characteristics
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Publication Formats
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Rodentia
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Vertebrates
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Chordata (phylum)
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Mammalia (class)
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Vertebrata (subphylum)
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Muridae (family)
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Animal pathology & diseases.
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Oncology.
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Medical -- Oncology.
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Science -- Life Sciences -- Zoology -- General.
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Vertebrates
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Oncology, Experimental
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Muridae
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Mice
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Metastasis
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Mammals
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Diseases -- Animal models
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Diseases
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Chordata
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Cancer invasiveness
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Cancer -- Animal models
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Mice as laboratory animals
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| Genre/Form |
Laboratory manuals.
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Manuels de laboratoire.
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| Form |
Electronic book
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| Author |
Eferl, Robert, editor
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Casanova, Emilio, editor
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| ISBN |
9781493922970 |
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1493922971 |
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1493922963 |
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9781493922963 |
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