| Description |
1 online resource (xiii, 482, 125 pages) : illustrations |
| Series |
Handbook of clinical neurology ; v. 107 |
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Handbook of clinical neurology ; 3rd ser., v. 107. 0072-9752
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| Contents |
Front Cover; Epilepsy; Copyright; Handbook of Clinical Neurology 3rd Series; Foreword; Preface; Contributors; Contents of Part I; Contents of Part II; Section 1: Basic Mechanisms; Chapter 1: Molecular basis of acquired epileptogenesis; Introduction; Which Genes are Altered At Different Phases of Epileptic Process and what is Their Function?; Synaptic Transmission and Ion Transport; Immune Function; Conclusion; Acknowledgments; References; Chapter 2: Cellular bases of focal and generalized epilepsies; Introduction; Intrinsic Properties of Neurons; Excitatory Projection Cells |
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Inhibitory Local Circuit InterneuronsSynaptic Properties of Neurons; Excitatory Circuits; Glutamate as an Excitatory Agent; Developmental and Activity-dependent Changes in Synaptic Excitation; Local Inhibitory Circuits; GABA as an Inhibitory Agent; Plasticity Mediated by Changes in GABAergic Function; Modulation of Neuronal Excitability; Astrocytes; Regulation of Extracellular Potassium Concentration; Glutamate Uptake; Ionic Changes; Neuropeptides and Other Neurotransmitters; Circulating Agents; Pathological Processes; Developmental Abnormalities; Trauma-induced Changes |
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Example of Focal Epilepsy -- Temporal Lobe epilepsyExample of Generalized Epilepsy -- Generalized Epilepsy With Febrile Seizures Plus (GEFS+); Concluding Comment; Acknowledgments; References; Chapter 3: Epilepsy as a dynamic disease of neuronal networks; Introduction; How May the Stability of Neuronal Networks be Maintained and Disturbed in epilepsy?; What Kind of Mechanism can Mediate Homeostatic Regulation of Neuronal Excitability? |
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What is the Role of Disturbance of Cellular Homeostatic Processes (ionic or Synaptic) in Promoting Changes to the Stability of neuronal networks, leading to epileptogenesis?How May Transitions Between Normal and Epileptic Behavior Occur in Thalamocortical Networks?; How can the Same Basic Neuronal Network cause Spindle Oscillations and, Occasionally, also SWDs?; Critical Parameters of the Thalamocortical Network; What makes the Neuronal Network Switch its Behavior from a State Characterized by Normal Oscillations and Normal Behavior to another State characterized by SWD and absence seizures? |
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What are the Roles of the Thalamus and Cortex in the Generation of SWDs?The Cortical Driver of SWDs; How May Transitions Between Normal and Epileptic Behavior Occur in Neuronal Networks of the Hippocampal System?; How can Neuronal Networks of the Mesial Temporal Lobe cause Normal Behavior and occasionally also Epileptic Seizures?; What are the Critical Parameters Responsible for the Change in Network Dynamics Leading to MTLE Seizures? |
| Summary |
Epilepsy, Part I, Basic Principles and Diagnosis, Volume 107, in the Handbook of Clinical Neurology series offers a comprehensive review of our knowledge of the field today, including epidemiology, basic mechanisms, animal models, and topics of increasing interest such as the role of inflammation in epilepsy. It provides a comprehensive approach to description of the clinical, electrographic and imaging aspects of the epilepsies, with a clear outline of contemporary classification and the role of modern diagnostic techniques, as well as neuropsychological and psychiatric aspects of epilepsy. Chapters are authored by internationally respected neurologists with varied perspectives insuring depth to the content. A volume in the Handbook of Clinical Neurology series, which has an unparalleled reputation as the world's most comprehensive source of information in neurology. International list of contributors including the leading workers in the field. Describes the advances which have occurred in clinical neurology and the neurosciences, their impact on the understanding of neurological disorders and on patient care |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Description from online resource (viewed January 31, 2013) |
| Subject |
Epilepsy.
|
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Epilepsy -- Diagnosis
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Epilepsy
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Epilepsy -- diagnosis
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PSYCHOLOGY -- Neuropsychology.
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Epilepsy
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Epilepsy -- Diagnosis
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| Form |
Electronic book
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| Author |
Stefan, Hermann.
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Theodore, William H.
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| ISBN |
9780444535054 |
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0444535055 |
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