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Book Cover
E-book
Author Baram, Tallie Z

Title Febrile Seizures New Concepts and Consequences
Edition 2nd ed
Published San Diego : Elsevier Science & Technology, 2022

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Description 1 online resource (370 p.)
Contents Intro -- Febrile Seizures: New Concepts and Consequences -- Copyright -- Contents -- Contributors -- Part I Epidemiology of febrile seizures -- Chapter 1 The incidence and prevalence of febrile seizures and febrile status epilepticus -- Introduction -- What is a febrile seizure? -- Historical perspective -- Definitions of febrile seizures -- National Institutes of Health, International League Against Epilepsy, and American Academy of Pediatrics Definitions -- Simple and complex febrile seizures -- Febrile status epilepticus -- Determining febrile seizure incidence and prevalence
Definitions of epidemiological terms -- Study designs to determine incidence and prevalence -- Case ascertainment: Was it a febrile seizure? -- How common are febrile seizures? -- Key studies -- Geographical variation in febrile seizures -- Seasonal variation in febrile seizures -- Febrile seizures are slightly more common in boys -- Why do we need epidemiological data? -- References -- Part II Genetic and acquired syndromes associated with febrile seizures -- Chapter 2 The evolving genetic landscape of febrile seizures and GEFS + -- Background
Genetic approaches used to study the genetics of GEFS + -- Single-gene causes of GEFS + ( Table 1) -- Genes with limited evidence for link to FS + /GEFS + ( Table 2) -- Common genetic risk variants for FS + /GEFS + -- Genetic testing in the clinical setting -- Summary and future directions -- References -- Chapter 3 SCN1A and Dravet syndrome -- Introduction -- Nav1.1 channel dysfunction in DS -- The role of SCN1A variants in the genetics of DS -- Sodium channel function and dysfunction in neuronal excitability
Effects of temperature on sodium channels and Dravet-associated SCN1A variants -- Circuit-level mechanisms of Dravet syndrome -- Axonal dysfunction -- Synaptic dysfunction -- Cell-specific dysfunction -- From cells to circuits -- Beyond seizures: Broader aspects of the Dravet syndrome phenotype -- Summary -- Acknowledgments -- References -- Chapter 4 Ion channels and febrile seizures: It's not just SCN1A -- Introduction -- Ion channel genes with a strong association with FS -- Scn1a -- Scn2a -- Scn1b -- Hcn -- GABA A receptors -- Gabra1 -- Gabrb3 -- Gabrg2
Ion channel genes with a weak association with FS -- Genes other than ion channel genes that modulate neuronal excitability -- Potential pathological mechanisms underlying FS -- References -- Part III Febrile status epilepticus -- Chapter 5 Neuroimmunologic aspects of febrile status epilepticus -- Neuroinflammation, FSE, and epilepsy -- IL-1R/toll-like receptor signaling -- Animal models of FSE and the IL-1ß system -- Genetic studies supporting the role of inflammation in FSE -- Cytokines associated with febrile seizures and FSE in humans
Notes Description based upon print version of record
Cytokines as biomarkers of acute hippocampal injury following FSE and epileptogenesis
Bibliography References -- Chapter 8 Cognitive outcomes of febrile status epilepticus -- Early development and overall functioning -- Memory -- Language -- Visuospatial -- Attention, working memory, and executive functioning -- Achievement and school outcomes -- Summary -- References -- Part IV The neurobiology of FS and FSE: Experimental approaches -- Chapter 9 Why do febrile seizures involve specifically the developing brain? -- Introduction -- Possible mechanisms of febrile seizure -- Genetic factors -- Role of cytokines -- Direct temperature effects -- Developmental factors of increased susceptibility to febrile seizures -- Neural circuit development -- GABAergic neurotransmission -- Glutamatergic neurotransmission -- Intrinsic neuronal excitability -- Conclusions -- References -- Chapter 10 Contributions of cytokines to febrile seizures -- Introduction -- Fever and hyperthermia -- What are cytokines? -- Animal models of febrile seizures -- Evidence for brain cytokine involvement in rodent febrile seizure models -- Evidence for brain cytokine involvement in febrile seizures in children -- Cellular mechanisms underlying cytokine action in the brain -- Conclusions and future directions -- References -- Chapter 11 Experimental models of febrile seizures and febrile status epilepticus -- The need for animal models: They provide causality and mechanisms -- Considerations and choices of animal models -- Choice of species and "background" genetics -- Age -- Genetic animal models of febrile seizures and related syndromes -- Models of simple FS, recurrent FS, FSE, and epileptogenesis -- Modes and models for generating experimental FS and FSE -- What have the models taught us? What can they not teach us? -- References -- Part V The neurobiology of FSE-induced epilepsy and cognitive deficits: Experimental approaches
Form Electronic book
Author Shinnar, Shlomo
Stafstrom, Carl E
ISBN 9780323984188
0323984185