| Description |
1 online resource |
| Contents |
TITLE PAGE; COPYRIGHT PAGE; PREFACE; CONTRIBUTORS; CHAPTER 1 Lysophosphatidic Acid (LPA) Receptor Signaling; 1.1. INTRODUCTION; 1.2. LPA METABOLISM; 1.3. AUTOTAXIN; 1.4. LPA RECEPTORS; 1.5. LPA RECEPTOR AGONISTS AND ANTAGONISTS; CHAPTER 2 Sphingosine 1-Phosphate (S1P) Receptors; 2.1. INTRODUCTION; 2.2. S1P METABOLISM/ENZYME, AND TRANSPORT; 2.3. S1P RECEPTOR SUBTYPES, AND PHYSIOLOGICAL FUNCTIONS; 2.4. CONCLUDING REMARKS; CHAPTER 3 Global Gene Expression Program of Lysophosphatidic Acid (LPA)-Stimulated Fibroblasts; 3.1. INTRODUCTION; 3.2. THE GLOBAL TRANSCRIPTIONAL RESPONSE OF MEFS TO LPA |
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3.3. UPREGULATED GENES3.4. DOWNREGULATED GENES; 3.5. INDUCTION OF GENES THAT ENCODE SECRETED FACTORS; 3.6. OVERLAP BETWEEN THE EXPRESSION PROFILES OF LPA AND EGF; 3.7. CONCLUSIONS; ACKNOWLEDGMENTS; CHAPTER 4 Identification of Direct Intracellular Targets of Sphingosine 1-Phosphate (S1P); 4.1. INTRODUCTION; 4.2. INTRACELLULAR TARGETS FOR S1P; 4.3. METHODS TO IDENTIFY INTRACELLULAR S1P TARGETS; 4.4. OTHER POTENTIALLY USEFUL METHODS TO IDENTIFY LIPID BINDING PROTEINS; 4.5. CONCLUDING REMARKS; ACKNOWLEDGMENTS |
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CHAPTER 5 Lysophospholipid Receptor Signaling Platforms: The Receptor Tyrosine Kinase-G Protein-Coupled Receptor Signaling Complex5.1. INTRODUCTION; 5.2. LYSOPHOSPHOLIPID RECEPTOR-RECEPTOR TYROSINE KINASE COMPLEXES; 5.3. OTHER LYSOPHOSPHOLIPID RECEPTOR SIGNALING PLATFORMS; 5.4. OTHER EXAMPLES OF RTK-GPCR SIGNALING PLATFORMS; 5.5. INTERACTION OF RGS PROTEINS WITH RECEPTOR TYROSINE KINASE-LYSOPHOSPHOLIPID RECEPTOR SIGNALING COMPLEXES; 5.6. S1P AND RTK TRANSACTIVATION; 5.7. APPROACHES FOR THE STUDY OF RECEPTOR TYROSINE KINASE-LYSOPHOSPHOLIPID RECEPTOR SIGNALING COMPLEXES |
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5.8. SOME USEFUL PROTOCOLS FOR STUDYING RTK-LYSOPHOSPHOLIPID RECEPTOR SIGNALING PLATFORMS5.9. CONCLUSION; ACKNOWLEDGMENT; CHAPTER 6 Autotaxin: A Unique Ecto-Type Pyrophosphodiesterase with Diverse Functions; 6.1. HISTORY OF AUTOTAXIN (ATX); 6.2. STRUCTURE OF ATX; 6.3. EXPRESSION OF ATX; 6.4. ATX KNOCKOUT MICE AND TRANSGENIC MICE; 6.5. ROLE OF ATX IN BLOOD VESSEL FORMATION; 6.6. ROLE OF ATX IN CANCER; 6.7. CLINICAL ASPECTS OF ATX; 6.8. ATX INHIBITORS; 6.9. AUTOTAXIN RESEARCH PERSPECTIVES |
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CHAPTER 7 Studies on Autotaxin Signaling in Endocytic Vesicle Biogenesis and Embryonic Development Using Whole Embryo Culture and Electroporation7.1. INTRODUCTION; 7.2. RESULTS AND DISCUSSION; 7.3. METHODS; ACKNOWLEDGMENTS; CHAPTER 8 Standardization and Quantification of Lysophosphatidic Acid Compounds by Normal-Phase and Reversed-Phase Chromatography-Tandem Mass Spectrometry; 8.1. PREPARATION AND HANDLING OF LYSOPHOSPHATIDIC ACID (LPA) COMPOUNDS; 8.2. 1H AND 31P NMR CHARACTERIZATION; 8.3. LC/MS/MS OF LPA COMPOUNDS; 8.4. DISCUSSION; ACKNOWLEDGMENTS |
| Summary |
"This state-of-the-art reference addresses lysophospholipids, a special kind of fat that has been found to have a growing number of receptors within the cell and that has important, natural roles in the body, being essential for normal reproduction, development, maturation and life. This book covers the biochemistry, interactions, and signaling of lysophospholipids as well as its potential for producing new therapies for a range of medically important human diseases. Bringing together current knowledge in lysophospholipid signaling, this represents a must-have book for all academic, industrial, and medical school and hospital libraries"--Provided by publisher |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record and CIP data provided by publisher |
| Subject |
Lysophospholipids.
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Receptors, Lysophospholipid -- physiology
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Receptors, Lysophospholipid -- metabolism
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Signal Transduction -- physiology
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Lysophospholipids
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SCIENCE -- Life Sciences -- Anatomy & Physiology.
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Lysophospholipids.
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| Form |
Electronic book
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| Author |
Chun, Jerold, 1959-
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| LC no. |
2012046208 |
| ISBN |
9781118531303 |
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1118531302 |
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9781118531358 |
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1118531353 |
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9781118531273 |
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1118531272 |
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9781118531426 |
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1118531426 |
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0470569050 |
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9780470569054 |
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