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Book Cover
E-book
Author Butler, John M

Title Fundamentals of Forensic DNA Typing
Published Burlington : Elsevier Science, 2009

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Description 1 online resource (519 pages)
Contents FRONT COVER; FUNDAMENTALS OF FORENSIC DNA TYPING; COPYRIGHT PAGE; CONTENTS; FOREWORD; INTRODUCTION; NEW MATERIAL IN THIS EDITION; ACKNOWLEDGMENTS; ABOUT THE AUTHOR; CHAPTER 1 Overview and History of DNA Typing; OVERVIEW OF THE CRIMINAL JUSTICE SYSTEM; A BRIEF HISTORY AND OVERVIEW OF FORENSIC DNA ANALYSIS; STEPS IN DNA SAMPLE PROCESSING; DNA ANALYSIS INVOLVES COMPARISONS; THE LABORATORY REPORT; COMPARISONS TO COMPUTER TECHNOLOGY; READING LIST AND INTERNET RESOURCES; CHAPTER 2 Basics of DNA Biology and Genetics; BASIC DNA PRINCIPLES; POPULATION VARIATION; INTRODUCTORY GENETIC PRINCIPLES
READING LIST AND INTERNET RESOURCESCHAPTER 3 Historical Methods; A COMPARISON OF DNA TYPING METHODS; THE PRE-DNA YEARS (1900-1985); THE FIRST DECADE OF DNA TESTING (1985-1995); RFLP-BASED DNA TESTING; EARLY PCR-BASED DNA TESTING; THE SECOND DECADE OF DNA TESTING (1995-2005); MITOCHONDRIAL DNA SEQUENCING; ADVANTAGES AND LIMITATIONS OF DNA TYPING METHODS; READING LIST AND INTERNET RESOURCES; CHAPTER 4 Sample Collection, Storage, and Characterization; SAMPLE COLLECTION; SAMPLE STORAGE; SAMPLE CHARACTERIZATION; READING LIST AND INTERNET RESOURCES; CHAPTER 5 DNA Extraction; DNA EXTRACTION
SOLID-PHASE DNA EXTRACTION METHODSDIFFERENTIAL EXTRACTION; PCR INHIBITORS AND DNA DEGRADATION; READING LIST AND INTERNET RESOURCES; CHAPTER 6 DNA Quantitation; WHY QUANTIFY DNA?; DNA QUANTITIES USED; DNA QUANTITATION METHODS; COMPARISON OF METHODS; READING LIST AND INTERNET RESOURCES; CHAPTER 7 DNA Amplification (The Polymerase Chain Reaction); POLYMERASE CHAIN REACTION (PCR) PROCESS; MULTIPLEX PCR; PCR INHIBITION; PRECAUTIONS AGAINST CONTAMINATION; READING LIST AND INTERNET RESOURCES; CHAPTER 8 Short Tandem Repeat Markers; GENETIC MARKERS AND REPEATED DNA SEQUENCES; CORE STR MARKERS
COMMERCIALLY AVAILABLE STR KITSGENDER IDENTIFICATION WITH AMELOGENIN; STRBASE: A HELPFUL SOURCE OF INFORMATION ON STRS; READING LIST AND INTERNET RESOURCES; CHAPTER 9 Fundamentals of DNA Separation and Detection; DNA SEPARATION; DNA DETECTION; INSTRUMENT PLATFORMS FOR DNA SEPARATION AND DETECTION; READING LIST AND INTERNET RESOURCES; CHAPTER 10 STR Genotyping and Data Interpretation; STEPS IN STR GENOTYPING AND DATA INTERPRETATION; FACTORS AFFECTING GENOTYPING RESULTS; EXTRA PEAKS OBSERVED IN THE DATA; DEVELOPING AN INTERPRETATION STRATEGY; READING LIST AND INTERNET RESOURCES
CHAPTER 11 Statistical Interpretation: Evaluating the Strength of Forensic DNA EvidencePOPULATION DATA; GENETIC FORMULAS; METHODS FOR STATING THE RARITY OF A DNA PROFILE; FREQUENCY ESTIMATE CALCULATIONS; LIKELIHOOD RATIO; SOURCE ATTRIBUTION; ADDITIONAL STATISTICAL CALCULATIONS; READING LIST AND INTERNET RESOURCES; CHAPTER 12 DNA Databases; VALUE OF DNA DATABASES; ASPECTS OF A NATIONAL DNA DATABASE; NATIONAL DNA DATABASES AROUND THE WORLD; THE U.S. NATIONAL DNA DATABASE; DNA DATABASE LAWS IN THE UNITED STATES; ISSUES AND CONCERNS WITH DNA DATABASES
Summary John Butler, bestselling author of Forensic DNA Typing, now applies his expertise on the subject of DNA analysis into an introductory textbook. Fundamentals of Forensic DNA Typing walks students step-by-step through the DNA analysis process beginning with collection of evidence at a crime scene to the statistical interpretation of the results. Also included are brief discussions of such news worthy topics as victim identification from the September 11, 2001 attacks, the identification of the remains of the Romanovs, the last Russian Royal family, and the O.J. Simpson case. New applications, su
Notes What if there are no hits after a database search?
Bibliography Includes bibliographical references and index
Notes Print version record
Subject DNA fingerprinting.
Forensic genetics.
DNA Fingerprinting -- methods
DNA -- physiology
Forensic Medicine -- methods
DNA Fingerprinting
MEDICAL -- Forensic Medicine.
MEDICAL -- Preventive Medicine.
MEDICAL -- Public Health.
DNA fingerprinting
Forensic genetics
Form Electronic book
ISBN 9780080961767
0080961762