| Description |
1 online resource (xvii, 414 pages) : color illustrations |
| Contents |
Intro -- Foreword -- Preface -- Acknowledgments -- Contents -- Editor and Contributors -- About the Editor -- Contributors -- 1: Emerging Tools for Generating Genomics Data -- 1.1 Introduction -- 1.1.1 History of Emergence of Genomics -- 1.2 Types of Genomics -- 1.2.1 Functional Genomics -- 1.2.2 Structural Genomics -- 1.2.3 Epigenomics -- 1.2.4 Metagenomics -- 1.2.5 Comparative Genomics -- 1.3 Methods for Genome Analysis -- 1.3.1 Low-Throughput Genome Sequencing Methods -- 1.3.2 High-Throughput Genome Sequencing Methods |
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1.4 Different Sequencing Strategies used for Genome Analysis -- 1.4.1 Shotgun Sequencing Approach -- 1.4.1.1 Whole-Genome Shotgun (WGS) Sequencing -- 1.4.2 Targeted Sequencing -- 1.4.3 Whole Exome Sequencing (WES) -- 1.4.3.1 Challenges -- 1.5 Other Techniques to Study Genome -- 1.5.1 Chromatin Immunoprecipitation Sequencing (ChIP-Seq) -- 1.5.2 Array Comparative Genomic Hybridization (aCGH) -- 1.5.3 SNP Microarray -- 1.5.4 Short Tandem Repeat (STR) Analysis -- 1.6 Molecular Cloning -- 1.6.1 pBR322 Vector -- 1.6.2 BAC -- 1.6.3 YAC -- 1.6.4 Viral Vectors -- 1.6.4.1 Adenoviruses |
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1.6.4.2 Herpes Simplex Virus (HSV) -- 1.6.5 Expression Vectors -- 1.6.5.1 pET Vector Series -- 1.7 Genome Databases -- 1.7.1 GenBank -- 1.7.2 DDBJ -- 1.7.3 Ensembl -- 1.7.4 European Nucleotide Archive (ENA) -- 1.7.5 dbGaP (Database of Genotypes and Phenotypes) -- 1.7.6 HGMD (Human Gene Mutation Database) -- 1.7.7 RefSeq (Reference Sequence Database) -- 1.7.8 1000 Genomes Project -- 1.8 Conclusion and Future Perspectives -- References -- 2: Computational Tools for Genomics Data Analysis -- 2.1 Introduction -- 2.2 Analysis of Genomics Data |
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2.3 Issues in the Analysis of Genomics Data -- 2.4 Computational Tools for Genomics Data Analysis -- 2.5 Conclusion -- References -- 3: Current Progress in Gene and Genome Annotation -- 3.1 Introduction -- 3.2 Structural Annotation -- 3.2.1 Masking and Repeat Identification -- 3.2.1.1 De Novo Approaches -- 3.2.1.2 Strategies Based on Homology -- 3.2.1.3 Structure-Based Methods -- 3.2.1.4 Comparative Genomic Methods -- 3.2.2 Evidence Alignment -- 3.2.3 Splice Identification -- 3.2.4 Prediction of Features -- 3.2.4.1 Ab Initio Methods -- 3.2.4.2 Homology-Based Methods |
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3.2.4.3 Combiners -- 3.3 Functional Annotation -- 3.3.1 Coding Sequence Function Prediction -- 3.3.2 Determination of the Functions of Noncoding Sequences -- 3.3.2.1 Homology-Based Approach -- 3.3.2.2 Phylogeny-Based Method -- Comparison of Whole-Genome Assemblies (WGAC) -- Whole-Genome Shotgun Sequence Detection (WSSD) -- Sequence Similarity-Based Methods -- Methods that Are Based on Structures -- 3.4 Visualization -- 3.4.1 File Formats -- 3.4.2 Genome Browsers -- 3.4.3 Genome Comparison Visualization -- 3.4.3.1 Dot Plots -- 3.4.3.2 Linear Representation |
| Summary |
This book provides a comprehensive overview of genomics and its diverse applications. Chapters cover genomics data generation methods, computational tools, gene annotation, transcriptomics, DNA barcoding, next-generation sequencing, functional genomics, metagenomics, synthetic genomics, microarray analysis, nutrigenomics, genome editing, and more. This book offers a valuable source of information for not only beginners in genomics, but also for students, researchers, scientists, clinicians, practitioners, policymakers, and stakeholders who are interested in harnessing the potential of genomics in many areas |
| Bibliography |
Includes bibliographical references |
| Notes |
3.4.3.3 Circular Representation |
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Description based on online resource; title from digital title page (viewed on September 18, 2024) |
| Subject |
Genomics.
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| Form |
Electronic book
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| Author |
Singh, Vijai, editor
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| ISBN |
9789819731695 |
|
9819731690 |
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