| Description |
1 online resource (viii, 258 pages) |
| Series |
Advances in Experimental Medicine and Biology ; v.1444 |
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Advances in experimental medicine and biology ; v. 1444.
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| Contents |
Intro -- Preface -- Contents -- Part I: From the Bench to the Bedside -- 1: Novel Insights into the Autoimmunity from the Genetic Approach of the Human Disease -- 1.1 Introduction -- 1.2 The Identification of the AIRE Gene -- 1.3 AIRE Has Domains Characteristic of the Transcriptional Regulator -- 1.4 AIRE Has a Unique Role in Guarding Self-Tolerance -- 1.5 APECED Starts Early in Childhood and Is Heterogenic -- 1.6 AIRE Mutations: Expanding Universe -- 1.7 Autoantibodies to Intracellular Enzymes -- 1.8 Autoantibodies to Cytokines Add Another Puzzle to the Tolerance Paradigm |
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1.9 Do We Have a Full Understanding of How AIRE Regulates Immune Tolerance? -- References -- 2: Learning the Autoimmune Pathogenesis Through the Study of Aire -- 2.1 Introduction -- 2.2 Animal Models of Aire Deficiency -- 2.3 Molecular Biology of Aire -- 2.4 Aire Controls the Differentiation Program of mTECs -- 2.5 The Tolerogenic Function of Aire -- 2.6 Single-Cell Approach for the Understanding of Aire -- 2.7 The Unique Role of Aire Achieved Only in mTECs -- 2.8 Adverse Effect of Aire in Tolerance Induction -- 2.9 Post-Aire mTECs -- 2.10 Aire Outside the Thymus |
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2.11 Beyond the Autoimmunity -- 2.12 Concluding Remarks -- References -- 3: Extrathymic AIRE-Expressing Cells: A Historical Perspective -- 3.1 APECED, Aire and Immune Tolerance -- 3.2 Extrathymic Aire Expression -- 3.3 Stage 1. Classical Biochemistry Tools for Aire Expression (1997-2010) -- 3.4 Stage 2. The Hunt for Aire-Expressing Cells by Transgenics (2008-Present) -- 3.5 Stage 3. Rethinking eTACs: Implementation of scRNAseq (2021-Present) -- 3.6 Is There a Non-immune Role of Extrathymic Aire? -- 3.7 Role of Extrathymic AIRE: TRA Transcription Model Versus Maturation Model |
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3.8 Conclusions -- References -- 4: Neoself Antigens Presented on MHC Class II Molecules in Autoimmune Diseases -- 4.1 Introduction -- 4.2 Presentation of Neoself Antigens by Aberrant Expression of MHC Class II Molecules -- 4.3 Neoself Antigens Presented on MHC Class II Molecules Are Targets of Autoantibodies -- 4.4 Presentation of Neoself Antigens by MHC Class II Molecule Is Associated with the Risk of Autoimmune Diseases -- 4.5 Mechanism of Autoantibody Production Through Neoself Antigen Presented on MHC Class II Molecules -- 4.6 Conclusions -- References |
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5: Regulatory T Cells for Control of Autoimmunity -- 5.1 Treg Cells in Immunological Self-Tolerance and Their Anomalies as a Cause of Autoimmune Disease -- 5.2 Mechanisms of Treg-Mediated Immune Suppression -- 5.3 Functional Adaptation and Maintenance of Treg Cells -- 5.4 Development of Treg Cells -- 5.4.1 Treg Development in the Thymus -- 5.4.2 Treg Development in the Periphery -- 5.5 Therapeutic Application of Treg Cells for Autoimmune Diseases -- 5.5.1 In Vivo Expansion of nTreg Cells by Low-Dose IL-2 or IL-2 Muteins -- 5.5.2 Adoptive Cell Therapy (ACT) with Treg Cells |
| Summary |
This book overviews ongoing and upcoming clinical applications of basic immunology. Recent advances in our knowledge of immunology coupled with new technologies have aided in the development of efficient cancer immunotherapy, as well as the control of emerging microorganisms such as SARS-CoV-2. However, knowledge of basic immunology has not been fully utilized even after the discoveries of immune checkpoint inhibition for cancer immunotherapy and the development of mRNA vaccination against SARS-CoV-2. There is still room for improving the clinical application of basic immunology. The book summarizes the achievements in clinical applications of basic immunology and highlights what can be further extended to make immunology a more practical human science. Basic immunology and its clinical applications are two wheels of the same cart in the immunology field, which aids in the development of more efficient cancer immunotherapy and rapid control of infectious diseases against microorganisms, including new viruses and classical toxoplasmosis. The exploration of ongoing and upcoming applications of basic immunology in this book makes it a useful resource for immunologists, physicians, molecular and genome biologists, bioinformaticians, and students in these fields |
| Subject |
Immunology.
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Molecular biology.
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Medicine.
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Medicine -- Research.
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Biology -- Research.
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Biochemistry.
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molecular biology.
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medicine (discipline)
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biochemistry.
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| Form |
Electronic book
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| Author |
Matsumoto, Mitsuru
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| ISBN |
9789819997817 |
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981999781X |
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