| Description |
1 online resource (418 p.) |
| Contents |
Intro -- Transcription and Translation in Health and Disease -- Copyright -- Contents -- Contributors -- About the editors -- Preface -- Section I: Introduction -- Chapter 1: Current perspective of transcriptional regulators in human health and diseases -- Introduction -- Key transcriptional regulators and their critical role in regulating the transcription -- Chromatin modifiers -- Histone modifications -- DNA methylation -- N6-methyladenosine (m6A) -- Noncoding RNAs -- Alternative splicing -- Transcription factors -- Super-enhancers -- Dysregulation of transcriptional regulators in diabetes |
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Dysregulation of transcriptional regulators in human cancers -- Chromatin regulators -- DNA methylation -- N6-methyladenosine (m6A) -- Noncoding RNAs -- Alternative splicing -- Misregulation of transcription factors (TFs) and mediator coactivation complex -- References -- Section II: Transcriptional and translational regulators in cancer -- Chapter 2: Role of alternative splicing in health and diseases -- Introduction -- Gene expression -- Transcription -- Posttranscriptional changes or RNA processing -- Translation -- Regulation of gene expression -- Splicing and alternative splicing |
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Regulation of alternative splicing: Splicing factors -- Technologies to find alternative splicing -- Splicing arrays -- Analysis of AS using microarray -- RNA-sequencing -- Analysis of AS using RNA_Seq -- Alternative splicing in disease -- References -- Chapter 3: Role of transcriptional and posttranscriptional regulation of sphingolipid genes in molecular heterogeneity of ... -- Introduction to sphingolipids -- Breast cancer heterogeneity -- Sphingolipid gene expression in different subtypes of breast cancer |
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Molecular mechanisms by which sphingolipids regulate gene expression in signaling cascades -- Posttranscriptional modifications -- References -- Chapter 4: Who dictates and when: Genetic and epigenetic dictatorships in breast cancer response and resistance to therapy -- Introduction -- Breast cancer subtypes -- Breast cancer treatment -- Response to therapy and drug resistance -- Genetic vs epigenetic dictators -- Genetic and epigenetic determinants effecting response to endocrine therapy in BC -- Genetic alterations-endocrine therapy -- Epigenetic alterations-endocrine therapy |
| Notes |
Description based upon print version of record |
| Genre/Form |
Electronic books
|
| Form |
Electronic book
|
| Author |
Sethi, Gautam
|
|
Pandey, Amit Kumar
|
| ISBN |
9780323995221 |
|
0323995225 |
|
