| Description |
1 online resource |
| Contents |
Intro -- Preface -- Organization of the Book -- Acknowledgments -- Contents -- About the Author -- Part I -- 1: Introduction to Cell Signaling Pathways and Brain Tumors -- 1.1 Cell-Signaling Pathway Classification -- 1.1.1 Endocrine Signaling -- 1.1.2 Autocrine Signaling -- 1.1.3 Paracrine Signaling -- 1.1.4 Intracrine Signaling -- 1.1.5 Juxtacrine Signaling -- 1.2 Introduction to Brain Tumors -- 1.2.1 Primary Brain Tumors -- 1.2.2 Brain Tumor Metastases -- 1.2.3 Benign Brain Tumors -- 1.2.4 Malignant Brain Tumors -- 1.2.4.1 Astrocytoma -- 1.2.4.2 Ependymoma |
|
1.2.4.3 Glioblastoma -- 1.2.4.4 Oligodendroglioma -- 1.2.4.5 Medulloblastoma -- 1.2.5 Symptoms -- References -- Part II -- 2: Wnt Cell Signaling Pathway in Brain Tumor Development -- 2.1 Canonical Pathway -- References -- 3: Notch Cell Signaling Pathway and Brain Tumors -- References -- 4: Sonic Hedgehog Cell Signaling Pathway and Medulloblastoma -- References -- 5: Role of the Shh Signaling Pathway in the Most Common Brain Tumor "Glioma" role in Glioma Growth -- References -- Part III -- 6: NANOG Stem Cell Marker and Its Role in Brain Tumor Development -- References |
|
7: Stem Cell Factor Sox2 and Brain Tumor Development -- References -- 8: Role of Neurotrophins in Brain Tumor Development -- 8.1 Role of Neurotrophins in Neuron Development -- 8.2 NGF and Brain Tumors -- 8.3 BDNF and Brain Tumor -- 8.4 NT3 and Brain Tumors -- 8.5 NT-4 and Brain Tumors -- 8.6 Dehydroepiandrosterone (DHEA) and Brain Tumor -- References -- 9: Role of NF-kB in Brain Tumor Development -- References -- Part IV -- 10: Role of Myc in Brain Tumor Development -- References -- 11: Role of p53 in Medulloblastoma Development -- References -- 12: Role of TP53 Gene in Glioma -- References |
|
13: Role of HIF-1 in Brain Tumor Development -- References -- Part V -- 14: EGFR and Its Role in Glioma Development -- References -- 15: Role of EFGR in Medulloblastoma Development -- References -- 16: Role of OCT4 in Glioblastoma -- References -- Part VI -- 17: Role of OCT4 in Pediatric Brain Tumor "Medulloblastoma" Development -- References -- 18: Mitogen-activated protein (MAP) kinase Roles in Paediatric Brain Tumor "Medulloblastoma" -- References |
| Summary |
This book provides acomprehensive overview of cell signalling pathways and morphogens in the genesis of brain tumours. It also explains the role of brain tumour stem cells in the brain tumour progression. It also elucidates the novel early biomarkers that can be utilized to diagnose brain tumours. It presents the basic developmental pathways and morphogens, including retinoic acid and TGF-b that promote brain tumorigenesis. The chapters illustrate the role of stem cells and stem cells mediated cell signalling pathways including, Sonic hedgehog, Notch, Wnt in the brain tumour growth. The chapters also emphasize the role of transcription factors, mainlyNanog, Sox, BMI1, HIF1 and Pax6 in the brain tumouriogensis. It highlights the role of NF-kb, Myc and neurotrophins in the brain tumour development. Finally, the book summarizes the potential early therapeutic targets and targeted drug discovery for brain tumours. |
| Notes |
Print version record |
| Subject |
Brain -- Tumors -- Pathogenesis
|
|
Cellular signal transduction.
|
|
Brain -- Tumors -- Treatment
|
|
Signal Transduction
|
|
Brain -- Tumors -- Treatment.
|
|
Cellular signal transduction.
|
| Form |
Electronic book
|
| ISBN |
9789811584732 |
|
9811584737 |
|
