Title The Ubiquitin-Proteasome Proteolytic System : From Classical Biochemistry to Human Diseases

Published Singapore : World Scientific Publishing Company, 2002

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Description 1 online resource (240 pages) Series Recent Advances in Human Biology Recent advances in human biology. Contents Preface ; The Ubiquitin System and Some of Its Roles in Cell Cycle Control ; References ; The Ubiquitin System and the N-End Rule Pathway ; Summary ; The Ubiquitin System ; The N-End Rule Pathway ; Physical Association of Ubiquitin Ligases and the 26S Proteasome Peptide Import and the N-End Rule Pathway The N-End Rule Pathway and Fidelity of Chromosome Segregation ; Concluding Remarks ; References ; Phosphorylation-Dependent Substrate Recognition in Ubiquitin-Mediated Proteolysis ; Abstract Modular Protein Interaction Domains Regulate Dynamic Cellular Behaviour Protein-Protein Interactions Determine Specificity in Ubiquitin-Mediated Proteolysis ; Cdk Activity and the Control of DNA Replication ; Discovery of SCF Ubiquitin Ligases Phosphorylation-Dependent Substrate Recognition by SCF Complexes Conservation of SCF Function in the Cell Cycle ; The Cdc4 Phospho-Degron ; Multi-Site Phosphorylation and Ultrasensitivity ; The Sicl-Cdc4 Interaction: Theoretical Considerations ; Discussion ; Prospects ; References The 26S Proteasome: A Supramolecular Assembly Designed for Controlled Proteolysis Introduction ; Structural Features of the 26S Proteasome ; Conclusions ; References ; Mechanisms and Regulation of Ubiquitin-Mediated Limited Processing of the NF-kBa Precursor Protein p105 ; Summary Summary Ubiquitin-proteasome-dependent proteolysis is central to an incredible multitude of processes in all eukaryotes, including the cell cycle, cell growth and differentiation, embryogenesis, apoptosis, signal transduction, DNA repair, regulation of transcription and DNA replication, transmembrane transport, endocytosis, stress responses, antigen presentation and other aspects of the immune response, the functions of the nervous system including circadian rhythms, axon guidance and acquisition of memory. This book tells the story of the ubiquitin system as we currently know it: from the regulation Bibliography Includes bibliographical references Notes Print version record Subject Proteins -- Metabolism. Proteolytic enzymes. Ubiquitin. Enzymes. Proteins. Hydrolases. Cysteine proteinases. Multienzyme complexes Ubiquitin Endopeptidases Cysteine Proteases Multiprotein Complexes Enzymes Ubiquitins Enzymes and Coenzymes Peptide Hydrolases Proteins Macromolecular Substances Hydrolases Chemicals and Drugs Amino Acids, Peptides, and Proteins Cysteine Endopeptidases Multienzyme Complexes enzyme. protein. Proteins Multienzyme complexes Hydrolases Enzymes Cysteine proteinases Proteins -- Metabolism Proteolytic enzymes Ubiquitin Form Electronic book Author Masucci, Maria G ISBN 9789812776877 9812776877

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