Title Zika virus biology, transmission, and pathology. Volume 1, The neuroscience of Zika / edited by Colin R. Martin, Caroline Hollins-Martin, Victor R. Preedy, Rajkumar Rajendram

Published London : Academic Press, 2021

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Description 1 online resource Contents Intro -- Zika Virus Biology, Transmission, and Pathways: The Neuroscience of Zika Virus -- Copyright -- Dedication -- Contents -- Contributors -- Foreword -- Preface -- Section A: Zika virus: Introductory chapters -- Chapter 1: Flaviviruses and where the Zika virus fits in: An overview -- Classification, diversity, and evolution -- Biology of transmission and persistence of MBF and TBF -- Virion structure, genome, and viral protein function -- Viral infection and replication cycle -- Host infection, immune response, and pathogenesis -- Flavivirus emergence and global burden -- Emergence of Aedes-borne flaviviruses -- Emergence of Culex-borne flaviviruses -- Policy and procedures -- Vector-borne flaviviruses diagnoses -- Mini-dictionary of terms -- Key facts of flavivirus genera -- Summary points -- References -- Chapter 2: The innate immune response during Zika virus infection -- Introduction -- Importance of pattern recognition receptors (PRRs) in sensing ZIKV -- Type I interferon in ZIKV infection -- Innate immunity against ZIKV in the skin -- Innate immunity against ZIKV in the placenta -- Innate immunity against ZIKV in the brain -- Involvement of autophagy -- Innate immunity evasion by ZIKV -- Policy and procedures -- mRNA expression of innate immune receptors determined by real time PCR -- Measuring innate immune receptors protein expression by flow cytometry -- Analyzing innate immune receptors localization and function -- Mini-dictionary of terms -- Key facts of innate immune response in ZIKV infection -- Summary points -- References -- Chapter 3: The public health perspective of Zika virus infection -- Introduction -- Timeline of the outbreaks -- Epidemiology: Distribution and determinants -- Geographical distribution -- Epidemiological determinants -- Public health consequences -- Prevention and control of Zika virus infections Better and sustained preparedness -- Implementation of strategic response framework -- Strengthening of International Health Regulations: Advice to travelers -- Strengthening of the sexual and reproductive health services -- Vector control, surveillance, risk communication, and promotion of research -- Bridging the gap between social and health inequalities -- Conclusion -- Policy and procedures -- Mini-dictionary of terms -- Key facts of the Zika virus infections -- Summary points -- References -- Chapter 4: Inequality in Zika virus and congenital Zika syndrome -- Inequalities in health -- The macro-drivers of the ZIKV -- Socioeconomic inequality in the prevalence of CZS -- Inequality in the exposure to ZIKV -- Inequality in susceptibility to the effect of ZIKV on CZS -- Sources of differential susceptibility -- Inequality in vector density -- Inequality in the vulnerability to the effect of vector density on ZIKV incidence -- The fundamental determination of ZIKV inequalities -- Socioeconomic implications -- Major knowledge gaps -- Policies to tackle the inequalities -- Mini-dictionary of terms -- Key facts -- Summary points -- References -- Chapter 5: Lifestyle factors and congenital Zika syndrome: Drugs, alcohol, and beyond -- Introduction -- Socioeconomic condition -- Lifestyle -- Access to information/health education -- Health-care access -- Abortion legislation -- Human rights -- Policy and procedures -- Multidisciplinary follow-up -- Multicenter follow-up of cohorts -- Mini-dictionary of terms -- Key facts -- Key facts of birth control methods -- Key facts of causes of mal formation in newborns -- Summary points -- References -- Chapter 6: Economic impact of Zika virus infection and associated conditions -- Introduction -- Brief history of ZIKV -- Health economics -- Economic and social impacts of recent outbreaks The cost of vector control -- The cost of diagnosis -- The cost of ZIKV-associated microcephaly -- The cost of congenital Zika syndrome -- The costs of ZIKV-associated Guillain-Barré syndrome -- Understand the economic evaluation of health technologies -- Economic evaluation of current and emerging health technologies -- Policy and procedures -- Mini-dictionary of terms -- Key facts -- Summary points -- References -- Chapter 7: Health promotion, health education, and risk communication for Zika virus disease -- Health promotion and education program during a noncrisis situation -- Social assessment -- Epidemiological assessment -- Educational and ecological assessment -- Administrative and policy assessment and intervention alignment phase -- Implementation -- Process evaluation -- Impact evaluation -- Outcome evaluation -- Risk communication for Zika virus disease -- Mini-dictionary of terms -- Key facts of Zika virus disease or ZVD -- Summary points -- References -- Chapter 8: Molecular mechanisms of Zika virus-induced neurological pathology -- Introduction -- ZIKV impairs mitotic spindle assembly -- Premature neural progenitor cell differentiation during ZIKV infection decreases the number of mature neurons -- ZIKV induces apoptosis in infected and bystander cells -- ZIKV interferes with developmental gene expression programs -- Neuroinflammation -- Conclusions and outstanding questions -- Policy and procedures: Measuring apoptosis -- Mini-dictionary of terms -- Key facts of the unfolded protein response -- Summary points -- References -- Chapter 9: Validation of Zika virus infections: Nonmolecular aspects, immunoassays, and beyond -- Introduction -- Symptoms and diagnosis of ZIKV infection: Basics and guidance -- Serological methods used in diagnosing ZIKV infection -- Basics about ZIKV antibody detection -- Methods for detecting ZIKV antibodies Virus neutralization assays -- Hemagglutination inhibition and immunofluorescence assays -- Immunoassays for detecting anti-ZIKV IgM, IgG, and IgA antibodies -- Policy and procedures -- DENV vaccine -- Mini-dictionary of terms -- Key facts of immunoassays used for the diagnosis of ZIKV infection -- Summary points -- References -- Chapter 10: Validation of Zika virus infections: A focus on molecular methods -- Introduction -- Molecular methods: ZIKV nucleic acids -- Basics of the nucleic acid amplification tests (NAATs) -- Real-time RT-PCRs -- Multiplex real-time RT-PCRs -- Conventional RT-PCRs -- Validation criteria -- Policy and procedures -- Mini-dictionary of the terms -- Key facts of molecular tests used for diagnosis of ZIKV infection -- Summary points -- References -- Chapter 11: Coinfection of Zika with Dengue and Chikungunya virus -- Introduction -- Timeline of coinfections -- Distribution of coinfections -- Detection of arboviruses in coinfections -- Clinical outcomes of coinfections -- Coinfection with ZIKV and DENV -- Coinfection with ZIKV and CHIKV -- Triple coinfection with ZIKV, DENV, and CHIKV -- Conclusion -- Policy and procedures -- Mini-dictionary of terms -- Key facts -- Summary points -- References -- Chapter 12: Zika virus, pathology, and control: Zika vaccine strategies in development -- Introduction -- Adaptive immunity to ZIKV infection -- The humoral immune response to ZIKV -- The T-cell immune response to ZIKV -- Key challenges facing Zika vaccine development -- Target populations for ZIKV vaccination -- The protection afforded by ZIKV vaccination -- Zika vaccine platforms -- Whole virus-based vaccines -- Subunit virus-based vaccines -- Clinical evaluation of Zika vaccine candidates -- Concluding remarks -- Policy and procedures -- Mini-dictionary of terms -- Key facts on Zika vaccine -- Summary points -- References Section B: Effects on neurological and body systems -- Chapter 13: The adult brain and neurologic manifestations of the Zika virus -- Introduction -- Zika virus and the nervous system: NeuroZika -- Guillain-Barré syndrome -- ZIKV-GBS viral diagnosis -- ZIKV-GBS neuroimaging -- GBS-Zika virus treatment and prognosis -- Others neurological complications -- General implications -- Policy and procedures -- Using the Brighton collaboration GBS working group criteria for GBS diagnosis -- Mini-dictionary of terms -- Key facts of NeuroZika -- Summary points -- References -- Chapter 14: Postmortem studies: Contribution to understand the pathogenesis of congenital Zika syndrome -- Introduction -- Pathogenesis of the lesions in CZS -- Conclusions -- Policy and procedures -- Mini-dictionary of terms -- Key facts -- Key facts of congenital Zika syndrome (CZS) -- Summary points -- References -- Chapter 15: Developmental trajectories in infants and toddlers born with congenital Zika syndrome -- Introduction -- Zika virus and the developing brain -- Congenital Zika syndrome -- Motor development -- Cognitive development -- Communication skills -- General implications -- Policy and procedures -- Measuring head circumference -- Using standardized tests to evaluate developmental skills in infants with CZS -- Mini-dictionary of terms -- Key facts -- Summary points -- References -- Chapter 16: Host genetic susceptibility to ZIKV congenital syndrome: A tale of twins -- Introduction -- Zika virus in Brazil -- Congenital Zika syndrome: Reasons for studying ZIKV effects in humans -- Risks for ZIKV-associated microcephaly and other CZS symptoms -- Twins: A powerful tool for investigating risks for ZIKV-associated microcephaly and CZS -- Twins cells are differentially infected by ZIKV -- Investigating the molecular NPCs twins differences -- Conclusion and follow-up Subject Zika virus. Zika virus infection. Zika Virus Zika Virus Infection Zika virus Zika virus infection Form Electronic book Author Martin, Colin R., 1964- Hollins Martin, Caroline. Preedy, Victor R. Rajendram, Rajkumar. ISBN 9780323903080 0323903088

Other Titles Neuroscience of Zika

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