| Description |
1 online resource (xiv, 363 pages) : illustrations (some color) |
| Series |
Cancer Drug Discovery and Development, 2196-9906 |
|
Cancer drug discovery and development, 2196-9906
|
| Contents |
Part I. Biology -- Hypoxia and Breast Cancer Metastasis / Luana Schito and Gregg L. Semenza -- Hypoxia and the DNA Damage Response / Monica M. Olcina and Ester M. Hammond -- Emerging Roles of Non-Coding RNAs in the Hypoxic Response / Mircea Ivan, Xiaoling Zhong, Simona Greco and Fabio Martelli -- Hypoxia and Reactive Oxygen Species / Agnes Görlach -- Hypoxia and Gene Expression / Maria Carla Bosco and Luigi Varesio -- Carbonic Anhydrase IX: From Biology to Therapy / Silvia Pastorekova and Claudiu T. Supuran -- Part II. Imaging -- Imaging the Hypoxic Tumor Microenvironment in Preclinical Models / Mary-Keara Boss, Gregory M. Palmer and Mark W. Dewhirst -- Clinical Imaging of Hypoxia / Michael R. Horsman, DMSc, Morten Busk, Thomas Nielsen, Marianne Nordsmark and Jens Overgaard -- Part III. Therapy -- Hypoxia, Metastasis, and Antiangiogenic Therapies / Dietmar W. Siemann, Yao Dai and Michael R. Horsman -- The Unfolded Protein Response and Therapeutic Opportunities / Carly M. Sayers, Souvik Dey, Stacey L. Lehman and Constantinos Koumenis -- Small Molecules Targeting the VHL/Hypoxic Phenotype / Raymond J. Louie, Mercè Padró, Amato J. Giaccia and Denise A. Chan -- Hypoxia and Radiation Therapy / Marianne Nordsmark, Jan Alsner, Morten Busk, Jens Overgaard and Michael R. Horsman -- Prodrug Strategies for Targeting Tumour Hypoxia / William R. Wilson, Kevin O. Hicks, Jingli Wang and Frederik B. Pruijn -- Exploiting "Hif Addiction" For Cancer Therapy / Nicole D. Fer and Annamaria Rapisarda -- Clinical Exploitation of Hypoxia / Geoff S Higgins and Adrian L Harris |
| Summary |
The tremendous progress in our understanding of the molecular mechanisms underlying tumor hypoxias has generated a great deal of enthusiasm and provides new opportunities to better understand and target the tumor microenvironment. This book emphasizes how changes in oxygen levels in the tumor microenvironment impact cancer cell biology and provide new opportunities for cancer therapy and the contribution of world renowned experts in tumor hypoxia makes this text an invaluable tool for understanding how hypoxia impacts the biology, imaging and therapy of human cancers. Basic and translational scientists alike will find this book to be a source of updated information and an opportunity to further strategic thinking in order to better understand and target the complexity of the hypoxic tumor microenvironment. This book is a reference tool for students, scientists and clinicians who are interested in the role of hypoxia in cancer biology and therapy |
| Notes |
Includes index |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Online resource; title from PDF title page (SpringerLink, viewed November 11, 2013) |
| Subject |
Anoxemia.
|
|
Cancer cells.
|
|
Cancer -- Molecular aspects.
|
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Hypoxia
|
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Neoplasms
|
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MEDICAL -- Forensic Medicine.
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MEDICAL -- Preventive Medicine.
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MEDICAL -- Public Health.
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Anoxemia
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Cancer cells
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Cancer -- Molecular aspects
|
| Form |
Electronic book
|
| Author |
Melillo, Giovanni (Oncologist), editor.
|
| ISBN |
9781461491675 |
|
1461491673 |
|
