| Description |
1 online resource (360 p.) |
| Contents |
Intro -- Autophagy Dysfunction in Alzheimer's Disease and Dementia -- Copyright -- Dedication -- Contents -- Contributors -- Foreword -- Preface -- Acknowledgments -- Section I: Degradation mechanisms of cells -- Chapter 1 Degradation mechanisms of cells -- 1 . Neurons are highly polarized cells with the sophisticated trafficking system -- 2 . Ubiquitin-proteasome system: UPS -- 2.1 Molecular mechanism for the ubiquitin-dependent degradation of proteins -- 2.2 Functional roles of the UPS in neurons -- 3 . Autophagy-endolysosomal system: APELS |
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3.1 Lysosome-mediated degradation of cellular macromolecules -- 3.2 Endocytic pathways to the lysosome -- 3.3 Endocytic pathways and endosome trafficking in neurons -- 3.4 Autophagic pathways to the lysosome -- 3.5 Functional roles of autophagy in neurons -- 3.6 Rab GTPases involves in autophagosome and endolysosome transport in neurons -- 4 . Integration of cellular degradation systems -- References -- Section II: Lysosomes -- Chapter 2 Lysosomes-neuronal degeneration in lysosomal storage disorders -- 1. Lysosomes -- 2. Lysosomal storage diseases |
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3. Impairment of lysosomal activity and alteration in the sphingolipid composition of cell membranes: A possible link ... -- 4. Involvement of mitochondrial impairment in the onset of neurodegeneration in lysosomal storage diseases -- 5. Involvement of lysosomal impairment in the neuroinflammation -- References -- Section III: The autophagic pathways -- Chapter 3 The autophagy pathway and its key regulators -- 1 . The autophagy machinery -- 2 . Key regulators and signaling pathways of autophagy -- 2.1 Regulation of autophagy by MTOR -- 2.2 Autophagy regulation by AMPK |
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2.3 Regulation of autophagy by inositol and calcium signaling -- 2.4 Autophagy regulation by reactive oxygen species and redox signaling -- 2.5 Regulation of autophagy by the unfolded protein response -- 2.6 Regulation of autophagy by transcription factors -- 2.7 Regulation of autophagy by microRNAs -- 2.8 Regulation of autophagy by posttranslational and epigenetic modulators -- 3 . Selective autophagy regulated by autophagic receptors -- 3.1 Mitophagy -- 3.2 Aggrephagy -- 3.3 ER-phagy -- 4 . Concluding remarks -- Acknowledgment -- References |
| Notes |
Description based upon print version of record |
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5.2 Excretion |
| Form |
Electronic book
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| Author |
Mutoh, Tatsuro
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| ISBN |
9780323899147 |
|
0323899145 |
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