| Description |
1 online resource |
| Series |
Cancer treatment and research ; volume 177 |
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Cancer treatment and research ; v. 177.
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| Contents |
Intro; Contents; Overview; 1 AIDS-Associated Malignancies; Abstract; 1.1 Introduction; 1.2 Gammaherpesvirus-Associated Malignancies; 1.3 Human Papillomavirus-Associated Malignancies; 1.4 Conclusion; References; 2 Molecular Biology of KSHV in Relation to HIV/AIDS-Associated Oncogenesis; Abstract; 2.1 Introduction; 2.2 KSHV Primary Infection; 2.2.1 Attachment, Entry, and Cellular Receptors; 2.2.2 Internalization and Intracellular Trafficking; 2.2.3 Regulation of Cellular Signaling Pathways During Primary Infection |
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2.2.4 Viral Gene Expression During Primary Infection and the Establishment of Viral Latency2.3 KSHV Life Cycle; 2.3.1 The Latency Locus; 2.3.2 KSHV Latency and Latent Nuclear Antigen (LNA) or Latency-Associated Nuclear Antigen (LANA); 2.3.3 Epigenetic Silencing and Regulation of KSHV Latency; 2.3.4 Reactivation of KSHV from Latency; 2.3.5 Viral Genes Required for Reactivation; 2.3.6 Factors Involved in KSHV Reactivation; 2.4 KSHV and Immunity; 2.4.1 KSHV and Innate Immunity; 2.4.2 KSHV and Adaptive Immunity; 2.5 KSHV and Tumorigenesis |
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2.5.1 Models of KSHV-Induced Cellular Transformation and Tumorigenesis2.5.2 KSHV Viral Genes and Tumorigenesis; 2.5.3 Cellular Genes/Pathways in KSHV-Associated Malignancies; 2.6 KSHV and Inflammation; 2.6.1 Kaposi's Sarcoma: A Tumor Associated with Inflammation; 2.6.2 Latent Viral Factors Involved in Inflammation; 2.6.3 Viral Lytic Genes Involved in Inflammation; 2.7 KSHV and Metabolism; 2.7.1 KSHV Reprograms Glucose Metabolism; 2.7.2 KSHV Reprogramming of Glutamine Metabolism for Host Cell Proliferation and Survival; 2.7.3 KSHV Infection Induces Lipogenesis |
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2.7.4 KSHV Depends on Glycolysis, Glutaminolysis, and FAS for Lytic Replication2.8 Conclusion and Perspectives; References; 3 Kaposi's Sarcoma-Associated Herpesvirus (KSHV)-Associated Disease in the AIDS Patient: An Update; Abstract; 3.1 Introduction; 3.2 KSHV and the Development of KS; 3.3 KSHV and the Development of Lymphomas; 3.4 Prevalence of Viral Infection; 3.5 The KSHV Genome; 3.6 Molecular Biology of KSHV-Associated Disease; 3.7 Therapies to Treat KS, PEL, and MCD; 3.8 Conclusions; Acknowledgements; References |
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4 Molecular Biology of EBV in Relationship to HIV/AIDS-Associated OncogenesisAbstract; 4.1 Introduction; 4.2 The Host Pathways Affected by EBV in Oncogenesis; 4.2.1 Resistance to Cell Apoptosis; 4.2.2 Cell Cycle and Proliferation; 4.2.3 Promotion of Cell Metabolism; 4.2.4 Evasion from Immune Surveillance; 4.2.5 Epigenetic Regulation Due to EBV Infection; 4.3 The Functions of EBV Proteins During Oncogenesis; 4.4 HIV-Associated Lymphoma in HIV/AIDS Patients; 4.5 Conclusions; References; 5 Human Papillomavirus Infection and Cervical Cancer in HIV+ Women; Abstract |
| Summary |
In this book, leading experts examine the clinical and biological aspects of viruses known to play a role in the oncogenesis of AIDS-associated cancers and non-AIDS-defining malignancies more commonly observed in HIV-infected individuals. Among the malignancies considered are those associated with Kaposi sarcoma-associated herpesvirus (KSHV) or Epstein-Barr virus (EBV), Merkel cell carcinoma due to Merkel cell polyomavirus (MCPyV), human papillomavirus (HPV)-associated anogenital and oropharyngeal cancers, and hepatitis B and C virus (HBV/HCV)-associated liver cancers. It also provides detailed information on the molecular biology of the causative viral agents and guidance on the specific treatment required in this special population. Covering all the important advances in our understanding made since the first edition was published in 2007, including the discovery and characterization of MCPyV, which brought the number of known human oncoviruses to seven, this new edition is a valuable resource for members of the scientific and healthcare community and active researchers in this field |
| Bibliography |
Includes bibliographical references |
| Notes |
5.1 Biology of Human Papillomavirus and HPV-Associated Cervical Cancer |
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Online resource; title from digital title page (viewed on February 15, 2019) |
| In |
Springer eBooks |
| Subject |
AIDS malignancies.
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Carcinogenesis.
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Oncogenic viruses.
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Opportunistic infections.
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Oncogenic Viruses
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AIDS-Related Opportunistic Infections
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Carcinogenesis
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Opportunistic infections
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Oncogenic viruses
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AIDS malignancies
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Carcinogenesis
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| Form |
Electronic book
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| Author |
Meyers, C. (Craig), editor.
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| ISBN |
9783030035020 |
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3030035026 |
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