| Description |
1 online resource |
| Contents |
Front Cover -- Hemostasis Management of the Pediatric Surgical Patient -- Hemostasis Management of the Pediatric Surgical Patient -- Copyright -- Dedications -- Contents -- Contributors -- Preface -- I -- Basics of hemostasis -- 1 -- Mechanisms of hemostasis -- Introduction to hemostasis -- Primary hemostasis -- On the front line-endothelium and blood vessels -- von Willebrand Factor -- Platelets -- Sticky situation: platelet adhesion -- Let's do this: platelet activation -- Getting together: platelet aggregation -- Secondary hemostasis -- Defining the pathways with assays |
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Don't go chasing waterfalls -- Vitamin K-dependent coagulation proteins and the cell-based model -- It's complex-icated -- Extrinsic pathway Xase -- Intrinsic pathway Xase -- Prothrombinase -- Free agents: nonmembrane-bound coagulation factors -- Factor XI -- Factor XII -- What it's all building to -- Prothrombin -- Fibrinogen -- Factor XIII -- Tertiary hemostasis -- Plasmin, the thrombin of fibrinolysis -- Breaking it down-activators of fibrinolysis -- Inhibitors of fibrinolysis -- Cellular receptors in the regulation of fibrinolysis -- The fibrinolytic pathway in thrombosis and beyond |
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Laboratory tests to support hypercoagulable disorders -- Assessment of anticoagulant or antiplatelet therapy -- Anticoagulant therapy -- Antiplatelet therapy -- Monitoring of hemostasis -- Whole blood assays -- Activated clotting time and heparin management systems -- Viscoelastic testing -- Platelet function testing -- Thrombin generation assay -- Summary -- References -- II -- Disorders of hemostasis in children -- 4 -- Congenital bleeding and thrombotic disorders -- Congenital bleeding disorders -- Von Willebrand Disease -- Epidemiology -- Genetics -- Clinical presentation -- Diagnosis |
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Treatment -- Surgical management -- Platelet dysfunction -- Hemophilia A -- Epidemiology -- Genetics -- Clinical presentation -- Treatment -- Factor concentrates -- Nonfactor therapy -- Hemophilia B -- Epidemiology -- Genetics -- Treatment -- Surgical management of hemophilia A and B -- Inherited thrombophilias -- Introduction -- Background -- Pathophysiology -- Clinical manifestations and management -- Protein C deficiency -- Antithrombin deficiency -- Thrombophilia role in first and recurrent VTE -- Is there an indication for thrombophilia screening in pediatric VTE? |
| Summary |
References -- 2 - Developmental hemostasis -- Introduction -- Primary hemostasis: developmental -- Secondary hemostasis: developmental -- The procoagulant system -- Coagulation inhibitors -- Tertiary hemostasis: developmental -- Summary -- References -- 3 - Measuring and monitoring of hemostasis -- Introduction -- Measurement of hemostasis -- Conventional coagulation assays -- Prothrombin time -- Activated partial thromboplastin time -- Fibrinogen activity -- Preoperative hemostasis assessment -- Specialty assays -- Laboratory tests to support hypocoagulable disorders |
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For testing and prophylaxis in congenital thrombophilia |
| Form |
Electronic book
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| ISBN |
9780323904605 |
|
0323904602 |
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