| Description |
1 online resource (xii, 329 pages) : illustrations (some color) |
| Series |
Methods in molecular biology, 1940-6029 ; volume 1866 |
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Methods in molecular biology (Clifton, N.J.) ; v. 1866. 1064-3745
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| Contents |
Methods to study the role of methionine-restricted diet and methioninase in cancer growth control / Shushma Chaturvedi and Joseph R. Bertino -- Altered methionine metabolism in cancer cells / Robert M. Hoffman, Peter H. Stern, DennisW. Coalson, C. DouglasWallace, and Richard W. Erbe -- Linkage of methionine dependence and other features of malignancy / Robert M. Hoffman and Richard W. Erbe -- Isolation and characterization of methionine-independent clones from methionine-dependent cancer cells / Stacey L. Borrego, Da-Wei Lin, and Peter Kaiser -- Tumor-specific S/G2-phase cell cycle arrest of cancer cells by methionine restriction / Robert M. Hoffman and Shuya Yano -- Preclinical breast cancer models to investigate metabolic priming by methionine restriction / Elena Strekalova, Dmitry Malin, Harisha Rajanala, and Vincent L. Cryns -- Efficacy of methionine-restricted diets on cancers in vivo / Robert M. Hoffman, Yasunori Hoshiya, and Weiyan Guo -- Dietary methionine restriction-based cancer chemotherapy in rodents / Robert M. Hoffman and Peter H. Stern -- Clinical studies of methionine-restricted diets for cancer patients / Robert M. Hoffman -- Development of recombinant methioninase for cancer treatment / Robert M. Hoffman, Yuying Tan, Shukuan Li, Qinghong Han, Shigeo Yagi, Tomoaki Takakura, Akio Takimoto, Kenji Inagaki, and Daizou Kudou -- Methioninase cell-cycle trap cancer chemotherapy / Robert M. Hoffman, Shuya Yano, and Kentaro Igarashi -- High efficacy of recombinant methioninase on patient-derived orthotopic xenograft (PDOX) mouse models of cancer / Robert M. Hoffman, Takashi Murakami, Kei Kawaguchi, Kentaro Igarashi, Yuying Tan, Shukuan Li, and Qinghong Han -- Total methionine restriction treatment of cancer / Robert M. Hoffman, Demetrius M. Kokkinakis, and Eugene P. Frenkel -- Methioninase gene therapy / Robert M. Hoffman, Kenji Miki, Waddah Al-Refaie, Mingxu Xu, and Yuying Tan -- Selenomethionine and methioninase : selenium free radical anticancer activity / Julian E. Spallholz -- Safety and toxicity of recombinant methioninase and polyethylene glycol (PEG) recombinant methioninase in primates / Robert M. Hoffman, Zhijian Yang, Yuying Tan, Qinghong Han, Shukuan Li, and Shigeo Yagi -- Pilot phase I clinical trial of methioninase on high-stage cancer patients : rapid depletion of circulating methionine / Robert M. Hoffman, Yuying Tan, Shukuan Li, Qinghong Han, Jorge Zavala Sr, and Jorge Zavala Jr -- Methionine gamma lyase from Clostridium sporogenes increases the anticancer efficacy of doxorubicin on A549 cancer cells in vitro and human cancer xenografts / V.S. Pokrovsky, N. Yu. Anisimova, D. Zh. Davydov, S.V. Bazhenov, N.V. Bulushova, G.B. Zavilgelsky, V.Y. Kotova, and I.V. Manukhov -- Methionine restriction and life-span extension / Robert M. Hoffman -- L-[Methyl-11C] methionine-positron-emission tomography (MET-PET) / Robert M. Hoffman -- Is the Hoffman effect for methionine overuse analogous to the warburg effect for glucose overuse in cancer? / Robert M. Hoffman -- Recombinant methioninase as a DNA demethylation agent / Robert M. Hoffman and David Machover -- Homocysteine, thioretinaco ozonide, and oxidative phosphorylation in cancer and aging : a proposed clinical trial protocol / Kilmer S. McCully -- Afterword : oral methioninase--answer to cancer and fountain of youth? / Robert M. Hoffman, Qinghong Han, Kei Kawaguchi, Shukuan Li, and Yuying Tan -- Epilogue : why do we keep mis-targeting cancer chemotherapy when the methionine target has been obvious for more than a half-century? |
| Summary |
This book explores the methionine dependence of cancer and its effects on aging, a great story of science that is not widely known. The chapters in this book describe the discovery of methionine dependence of cancer; the molecular basis for the increased methionine demand of cancer cells and tumors; the clinical application of methionine dependence of cancer in PET imaging with [11C]methionine; the development of methioninases as cancer drugs; the anti-aging and anti-diabetes effects of methionine restriction; and the future of targeting methionine in the body for the elimination of cancer and for the extension of a healthy life-span. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Methionine Dependence of Cancer and Aging: Methods and Protocols is an important resource for researchers and scientists wishing to pursue this exciting and vital area of study." |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Online resource; title from PDF title page (SpringerLink, viewed February 6, 2019) |
| Subject |
Methionine.
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Cancer -- Molecular aspects.
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Cancer -- Chemotherapy.
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Aging.
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Methionine
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Neoplasms -- metabolism
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Aging
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Aging
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Cancer -- Chemotherapy
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Cancer -- Molecular aspects
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Methionine
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| Genre/Form |
Electronic books
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Laboratory manuals
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Laboratory manuals.
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Manuels de laboratoire.
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| Form |
Electronic book
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| Author |
Hoffman, Robert M., 1944- editor
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| ISBN |
9781493987962 |
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1493987968 |
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