Title Green Chemistry Strategies for Drug Discovery

Published Cambridge : Royal Society of Chemistry, 2015

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Description 1 online resource (339 pages) Series RSC Drug Discovery RSC drug discovery series. Contents Cover; Contents; Preface; Chapter 1 Introduction: The Five Ws of Pharmaceutical Green Chemistry; 1.1 Introduction; 1.2 What is Green Chemistry?; 1.3 Why Should the Pharmaceutical Industry Incorporate Green Chemistry?; 1.4 Who is Doing Green Chemistry?; 1.5 Where is Green Chemistry Being Applied?; 1.6 When Should Green Chemistry be Implemented?; 1.7 How is Green Chemistry Integrated into Drug Discovery?; References; Chapter 2 Barriers to Adopting Green Chemistry in Drug Discovery; 2.1 Introduction; 2.2 Economic Barriers; 2.2.1 Solvents; 2.2.2 Reagents 2.2.3 Recommendations for Overcoming Economic Barriers2.3 Technical Barriers; 2.3.1 Recommendations for Overcoming Technical Barriers; 2.4 Cultural Barriers; 2.4.1 Awareness of the 12 Principles within Drug Discovery; 2.4.2 Awareness of the 12 Principles in the Wider Chemistry Community; 2.4.3 Communication, within Drug Discovery and Beyond; 2.4.4 Definitions and Metrics; 2.4.5 Recommendations for Embedding a Green Chemistry Culture within Drug Discovery; 2.5 Opportunities; References; Chapter 3 Toward a Green Laboratory: One Reaction at a Time; 3.1 Introduction; 3.2 Synthetic Route Design 3.3 Planning Your Reaction3.3.1 Solvent Choices; 3.3.2 Reagent and Methodology Choices; 3.4 Reaction Setup; 3.5 Reaction Workup; 3.6 Purification and Waste; 3.7 Conclusion; References; Chapter 4 Greener Solvent Usage for Discovery Chemistry Analysis and Purification; 4.1 Introduction; 4.2 SFC versus HPLC for Chiral and Achiral Separations; 4.2.1 SFC Introduction; 4.2.2 SFC for Chiral Analysis/Purification; 4.2.3 SFC for Achiral Analysis/Purification; 4.3 Optimization of Analytical LC/MS Conditions for Reaction Monitoring/Final QC; 4.4 Optimizing Reverse Phase Purifications 4.5 Greener Solvent Alternatives and Solvent Reduction for Flash Purification4.5.1 Flash Purification Introduction; 4.5.2 Reduction of Organic Solvent Use During Silica Gel Chromatography; 4.5.3 Reducing Dichloromethane (DCM) Usage; 4.5.4 Measuring Progress in Solvent Reduction and DCM Replacement; 4.6 Flash SFC as Alternative to LC Based Flash Purification; 4.7 Conclusion; References; Chapter 5 Green Chemistry and High Throughput Screening; 5.1 Introduction; 5.2 Screening in Medicinal Chemistry; 5.3 Setting up a Reaction Screen; 5.3.1 Workflow of Screening 5.3.2 How Low Can You Go? Material Requirements5.3.3 Reaction Design -- Coverage of Chemical Space; 5.3.4 Strategies for Screening for Greener Solutions; 5.3.5 Data Capture, Analysis, and Visualization; 5.4 Case Studies in Reaction Screening; 5.4.1 Case Study 1 -- Amide Bond Formation; 5.4.2 Case Study 2 -- Suzuki Couplings; 5.5 Biotransformations; 5.6 Screening Gaseous/Heterogeneous Reactions; 5.7 Resolutions/Purifications and Purges; 5.8 Capturing Information/Conclusions; Acknowledgments; References; Chapter 6 Continuous Processing in Drug Discovery; 6.1 Introduction Summary A practical guide for academic and industrial chemists to incorporating Green Chemistry principles into the drug discovery discipline and its everyday workflows with maximum benefit Notes 6.2 Green Process Strategies Bibliography Includes bibliographical references at the end of each chapters and index Notes English Print version record Subject Pharmaceutical chemistry. Green chemistry. Drugs -- Design. Methodology. Pharmaceutical technology. Technology. Conservation of natural resources. Chemistry. Pharmacology. Physical sciences. Life sciences. Drug Design Combinatorial Chemistry Techniques Drug Discovery Green Chemistry Technology Methods Investigative Techniques Technology, Pharmaceutical Technology Chemistry, Pharmaceutical Conservation of Natural Resources Analytical, Diagnostic and Therapeutic Techniques and Equipment Technology, Industry, and Agriculture Chemistry Pharmacology Natural Science Disciplines Technology, Industry, Agriculture Biological Science Disciplines Disciplines and Occupations methodology. chemistry. pharmacology. physical sciences. biological sciences. Biochemistry. SCIENCE -- Life Sciences -- Biochemistry. SCIENCE -- Environmental Science (see also Chemistry -- Environmental) Green chemistry. Pharmaceutical chemistry. Form Electronic book Author Sneddon, Helen Shuster, Leanna Miller, Larry Richardson, Paul Gupton, B. Frank Budzinski, Kristi Richter, Daniel Clark, Alex Anastas, Nichloas Royal Society of Chemistry (Great Britain), Content Provider. ISBN 9781782622659 1782622659 9781782625537 1849739617 9781849739610 1782625534

Other Titles Drug Discovery RSC Drug Discovery

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