| Description |
1 online resource (1727 p.) |
| Contents |
Cover -- Title Page -- Copyright -- Dedication -- Contributors -- Foreword to the First Edition -- Preface -- Contents -- Section I: General Principles -- Chapter 1: Cancer Genetics -- Historic Perspective -- Genetic Changes -- Sporadic -- Hereditary -- Oncogenes -- Types of Oncogenes -- Tumor Suppressor Genes (Anti-Oncogenes) -- Epigenetic Changes -- Genetic Changes in Gynecologic Malignancies -- Endometrial Cancer -- Uterine Mesenchymal Tumors -- Ovarian Cancer -- Ovarian Sex Cord Stromal Tumors -- Cervical Cancer -- Vulvar Cancer -- Gestational Trophoblastic Disease |
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Chapter 2: Cancer Cell Biology -- Cell Growth and Proliferation -- Oncogenes -- Tumor Suppressor Genes -- DNA Repair -- DNA Damage Response Defects and Synthetic Lethality to Enhance Efficacy of Cancer Therapy -- Cell Death Pathways -- Autophagy -- Apoptosis -- Necrosis -- Cancer Stem Cells -- Cellular Senescence -- Cell Metabolism -- Hormone Metabolism -- Post-translational Modifications -- Cell Invasion and Metastasis -- Epithelial-to-Mesenchymal Transition -- Tumor Microenvironment -- Immune Checkpoints -- Angiogenesis -- Biomarkers -- Tumor Markers |
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Chapter 3: Biologic, Targeted, and Immune Therapy -- Inhibitors of Growth Factor Receptors -- EGFR Inhibitors -- EGFR Inhibitors-Small Molecules -- EGFR Inhibitors-Monoclonal Antibodies -- Her2/Neu Inhibitors -- Her2/Neu Inhibitors-Small Molecules -- Her2/Neu Inhibitors-Monoclonal Antibodies -- PDGFR Inhibitors-Monoclonal Antibodies -- Inhibitors of Angiogenesis -- VEGFR Inhibitors-Small Molecules -- VEGFR Inhibitors-Monoclonal Antibodies -- Inhibitors of Other Intracellular Kinases -- Small Molecules -- Braf (Rapidly Activated Fibrosarcoma) Inhibitors -- MEK1-2 (MAPK/ERK Kinase) Inhibitors |
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CDK 4-6 (Cyclin-Dependent Kinases 4-6) Inhibitors -- ALK (Anaplastic Lymphoma Kinase) Inhibitors -- PI-3K (Phosphatidylinositol 3-Kinase) Inhibitors -- mTOR (Mammalian Target of Rapamycin) Inhibitors -- Inhibitors of DNA Repair -- PARP (Poly-ADP Ribose-Polymerase) Inhibitors -- Immunotherapy -- Cytokines -- Monoclonal Antibodies -- Immune Checkpoint Inhibitors -- Anti-PD-1 (Programmed Cell Death Receptor-1) Antibodies -- Anti-PD-L1 (Programmed Cell Death Receptor Ligand-1) Antibodies -- Therapeutic Cancer Vaccines -- Cell-Based Vaccines -- Glycan-Based Vaccines -- Adoptive Cell Therapy |
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Chapter 4: Chemotherapy -- General Principles -- Tumor Growth and Chemotherapy -- Differential Sensitivity -- Therapeutic Index -- Brief History of Chemotherapy -- Biologic Factors Influencing Treatment -- Cell Kinetic Concepts -- Cancer Cell Growth -- Principles of Chemotherapy -- Neoadjuvant Chemotherapy -- Hyperthermic Intraperitoneal Chemotherapy -- Antibody-Drug Conjugates -- Chemotherapy in Pregnancy -- Drug Resistance -- Excretion -- Drug Interactions -- Combination Chemotherapy -- Clinical Benefit -- RECIST Criteria -- Dose Adjustment -- Carboplatin Dose Calculation |
| Notes |
Description based upon print version of record |
|
Toxicities and Their Management |
| Subject |
Generative organs, Female -- Cancer
|
| Form |
Electronic book
|
| Author |
Hacker, Neville F
|
| ISBN |
9781975142650 |
|
1975142659 |
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