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E-book

Title Novel therapeutic targets for anti-arrhythmic drugs / edited by George E. Billman
Published Hoboken, NJ : John Wiley & Sons, ©2010

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Description 1 online resource (xxiv, 573 pages) : illustrations
Contents Myocardial K+ channels : primary determinants of action potential repolarization / Noriko Niwa and Jeanne Nerbonne -- The "funny" pacemaker current / Andrea Barbuti [and others] -- Arrhythmia mechanisms in ischemia and infarction / Ruben Coronel [and others] -- Antiarrhythmic drug classification / Cynthia A. Carnes -- Repolarization reserve and proarrhythmic risk / András Varró -- Safety challenges in the development of novel antiarrhythmic drugs / Gary Gintant and Zhi Su -- Safety pharmacology and regulatory issues in the development of antiarrhythmic medications / Armando Lagrutta and Joseph J. Salata -- Ion channel remodeling and arrhythmias / Takeshi Aiba and Gordon F. Tomaselli -- Redox modification of ryanodine receptors by heart failure and cardiac arrhythmias and failure : a potential therapeutic target / Andriy E. Belevych, Dmitry Terentyev, and Sandor Györke -- Targeting Na+/CA²+ exchange as an antiarrhythmic strategy / Gundrun Antoons, Rik Willems, and Karin R. Sipido -- Calcium/calmodulin-dependent protein kinase II (CaMKII) : modulation of ion currents and potential role for arrhythmias / Lars S. Maier -- Selective targeting of ventricular potassium channels for arrhythmia suppression : feasible or risible? / Hugh Clements-Jewery and Michael Curtis -- Cardiac sarcolemmal ATP-sensitive potassium channel antagonists : a class of drugs that may selectively target the ischemic myocardium / George E. Billman -- Mitochondrial origin of ischemia-reperfusion arrhythmias / Brian O'Rourke -- Cardiac gap junctions : a new target for antiarrhythmic drugs : gap junction modulators / Anja Hagen and Stefan Dhein -- Novel pharmacological targets for the management of atrial fibrillation / Alexander Burashnikov and Charles Antzelevitch -- IKur, ultra-rapid delayed rectifier potassium current : a therapeutic target for atrial arrhythmias / Arun Sridhar and Cynthia A. Carnes -- Non-pharmacologic manipulation of the autonomic nervous system in human for the prevention of life-threatening arrhythmias / Peter J. Schwartz -- Effects of endurance exercise training on cardiac autonomic regulation and susceptibility to sudden cardiac death : a nonpharmacological approach for the prevention of ventricular fibrillation / George E. Billman -- Dietary omega-3 fatty acids as a nonpharmacological antiarrhythmic intervention / Barry London and J. Michael Frangiskakis
Summary Profiles potential treatment approaches for cardiac arrhythmias. Cardiac arrhythmias of ventricular origin are responsible for the deaths of nearly half a million Americans each year while atrial fibrillation accounts for about 2.3 million cases per year, a rate that is projected to increase 2.5 fold over the next half century. Effectively managing these cardiac rhythm disorders remains a major challenge for both caregivers and the pharmaceutical industry. Filling a gap in the current literature, Novel Therapeutic Targets for Antiarrhythmic Drugs presents the latest treatments for cardiac arrh
Bibliography Includes bibliographical references and index
Notes English
Print version record
Subject Myocardial depressants.
Arrhythmia -- Chemotherapy
Anti-Arrhythmia Agents
Arrhythmias, Cardiac -- drug therapy
HEALTH & FITNESS -- Diseases -- Heart.
MEDICAL -- Cardiology.
Arrhythmia -- Chemotherapy
Myocardial depressants
Form Electronic book
Author Billman, George Edward, 1954-
LC no. 2009020796
ISBN 9780470561416
0470561416
9780470561409
0470561408
0470261005
9780470261002
1282688391
9781282688391
9786612688393
6612688394