Description |
1 online resource (xxiv, 573 pages) : illustrations |
Contents |
Myocardial K+ channels : primary determinants of action potential repolarization / Noriko Niwa and Jeanne Nerbonne -- The "funny" pacemaker current / Andrea Barbuti [and others] -- Arrhythmia mechanisms in ischemia and infarction / Ruben Coronel [and others] -- Antiarrhythmic drug classification / Cynthia A. Carnes -- Repolarization reserve and proarrhythmic risk / András Varró -- Safety challenges in the development of novel antiarrhythmic drugs / Gary Gintant and Zhi Su -- Safety pharmacology and regulatory issues in the development of antiarrhythmic medications / Armando Lagrutta and Joseph J. Salata -- Ion channel remodeling and arrhythmias / Takeshi Aiba and Gordon F. Tomaselli -- Redox modification of ryanodine receptors by heart failure and cardiac arrhythmias and failure : a potential therapeutic target / Andriy E. Belevych, Dmitry Terentyev, and Sandor Györke -- Targeting Na+/CA²+ exchange as an antiarrhythmic strategy / Gundrun Antoons, Rik Willems, and Karin R. Sipido -- Calcium/calmodulin-dependent protein kinase II (CaMKII) : modulation of ion currents and potential role for arrhythmias / Lars S. Maier -- Selective targeting of ventricular potassium channels for arrhythmia suppression : feasible or risible? / Hugh Clements-Jewery and Michael Curtis -- Cardiac sarcolemmal ATP-sensitive potassium channel antagonists : a class of drugs that may selectively target the ischemic myocardium / George E. Billman -- Mitochondrial origin of ischemia-reperfusion arrhythmias / Brian O'Rourke -- Cardiac gap junctions : a new target for antiarrhythmic drugs : gap junction modulators / Anja Hagen and Stefan Dhein -- Novel pharmacological targets for the management of atrial fibrillation / Alexander Burashnikov and Charles Antzelevitch -- IKur, ultra-rapid delayed rectifier potassium current : a therapeutic target for atrial arrhythmias / Arun Sridhar and Cynthia A. Carnes -- Non-pharmacologic manipulation of the autonomic nervous system in human for the prevention of life-threatening arrhythmias / Peter J. Schwartz -- Effects of endurance exercise training on cardiac autonomic regulation and susceptibility to sudden cardiac death : a nonpharmacological approach for the prevention of ventricular fibrillation / George E. Billman -- Dietary omega-3 fatty acids as a nonpharmacological antiarrhythmic intervention / Barry London and J. Michael Frangiskakis |
Summary |
Profiles potential treatment approaches for cardiac arrhythmias. Cardiac arrhythmias of ventricular origin are responsible for the deaths of nearly half a million Americans each year while atrial fibrillation accounts for about 2.3 million cases per year, a rate that is projected to increase 2.5 fold over the next half century. Effectively managing these cardiac rhythm disorders remains a major challenge for both caregivers and the pharmaceutical industry. Filling a gap in the current literature, Novel Therapeutic Targets for Antiarrhythmic Drugs presents the latest treatments for cardiac arrh |
Bibliography |
Includes bibliographical references and index |
Notes |
English |
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Print version record |
Subject |
Myocardial depressants.
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Arrhythmia -- Chemotherapy
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Anti-Arrhythmia Agents
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Arrhythmias, Cardiac -- drug therapy
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HEALTH & FITNESS -- Diseases -- Heart.
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MEDICAL -- Cardiology.
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Arrhythmia -- Chemotherapy
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Myocardial depressants
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Form |
Electronic book
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Author |
Billman, George Edward, 1954-
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LC no. |
2009020796 |
ISBN |
9780470561416 |
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0470561416 |
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9780470561409 |
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0470561408 |
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0470261005 |
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9780470261002 |
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1282688391 |
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9781282688391 |
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9786612688393 |
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6612688394 |
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