Description |
1 online resource |
Series |
RSC drug discovery ; v. 33 |
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RSC drug discovery series ; v. 33.
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Contents |
Introduction to biomarker discovery and validation; Clinical context of proteomics biomarker discovery and validation, authority regulations; Biomarker discovery: Patient selection; Biomarker discovery: Experimental design and biobanking; Biomarker discovery: body fluids; Biomarker discovery: tissues; Biomarker discovery: mass spectrometry based profiling platforms; Biomarker discovery: array based profiling platforms; Biomarker discovery: data preprocessing for LC-MS data; Biomarker discovery: data preprocessing for Maldi imaging, and 2D electrophoresis and protein arrays data; Biomarker discovery: statistical analysis and validation; Biomarker validation: biomarker validation methods; Functional biomarker validation; Clinical application: case studies Clinical application: summary and future technology development trends |
Summary |
This book focuses on proteomics biomarker discovery and validation procedures from the clinical perspective. It provides an overview of current technology and the challenges encountered throughout the process. This covers all key stages, from biomarker discovery and validation, through to registration with the European and US regulatory authorities (FDA and EMEA). All the important elements (such as patient selection, sample handling, data processing, and statistical analysis) are described in detail and the reader is introduced to each topic with well-described examples or guidelines for best practice. Case studies are also included to demonstrate clinical applications. Individual chapters explain the best performing techniques for profiling complex body fluids and biomarker discovery. This includes the application of mass spectrometry imaging combined with chromatography in profiling platforms and the use of laser micro dissection and MALDI imaging to study tissues in their natural environment. Future developments needed to improve the success rate of translating biomarker discovery into useful clinical tests are also discussed. Common pitfalls and success stories are described as are the limitations of the various technologies involved. Broad and interdisciplinary in approach, this book provides an excellent source of information for industrial and academic researchers, and those managing biobanks |
Notes |
English |
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Title details screen (RSC Publishing; viewed on July 25, 2013) |
Subject |
Biochemical markers.
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Medical care.
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Chemistry.
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Public health.
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Biology.
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Physical sciences.
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Biochemistry.
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Liquid chromatography.
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Proteomics.
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Mass spectrometry.
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Methodology.
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Decision making -- Mathematical models.
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Genomics.
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Chromatographic analysis.
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Statistics.
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Life sciences.
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Biological products.
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Delivery of Health Care
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Epidemiologic Methods
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Medical Informatics Applications
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Chemistry
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Genetics
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Chemicals and Drugs
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Analytical, Diagnostic and Therapeutic Techniques and Equipment
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Medical Informatics
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Public Health
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Biology
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Natural Science Disciplines
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Quality of Health Care
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Disciplines and Occupations
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Health Care Quality, Access, and Evaluation
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Environment and Public Health
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Information Science
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Biochemistry
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Chromatography, Liquid
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Data Interpretation, Statistical
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Proteomics
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Mass Spectrometry
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Methods
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Biomarkers
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Biological Factors
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Chemistry Techniques, Analytical
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Decision Support Techniques
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Investigative Techniques
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Genomics
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Chromatography
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Statistics as Topic
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Biological Science Disciplines
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Health Care Evaluation Mechanisms
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Computational Biology
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Patient Care
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chemistry.
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public health.
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biology.
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physical sciences.
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biochemistry.
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liquid chromatography.
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mass spectrometry.
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methodology.
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chromatography.
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biological sciences.
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statistics.
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HEALTH & FITNESS -- Holism.
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HEALTH & FITNESS -- Reference.
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MEDICAL -- Alternative Medicine.
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MEDICAL -- Atlases.
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MEDICAL -- Essays.
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MEDICAL -- Family & General Practice.
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MEDICAL -- Holistic Medicine.
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MEDICAL -- Osteopathy.
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Statistics
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Public health
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Proteomics
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Physical sciences
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Methodology
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Medical care
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Mass spectrometry
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Liquid chromatography
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Life sciences
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Genomics
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Decision making -- Mathematical models
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Chromatographic analysis
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Chemistry
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Biology
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Biochemistry
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Biochemical markers
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Form |
Electronic book
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Author |
Horvatovich, Péter, 1972- editor.
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Bischoff, Rainer, 1956- editor.
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ISBN |
9781849734363 |
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1849734364 |
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