| Description |
1 online resource (227 pages) |
| Series |
Acta Neurochirurgica Supplement Ser. ; v. 127 |
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Acta neurochirurgica. Supplement ; 127.
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| Contents |
Intro; Preface; Contents; Vasospasm: A Personal Odyssey; History of Vasospasm; B.K.A. Weir; Selected Bibliography: Aneurysms and Vasospasm; Clinical Studies; Prognostic Factors and Outcome; Grade and Vasospasm; Cigarette Addiction; Outcome; Time Course of Vasospasm; Management Mortality and Timing of Surgery; Perioperative Care; Blood Flow and Angiographic Studies; Sequelae of Hemorrhage; Edema; Cerebral Infarction; Hematologic and Metabolic; Hydrocephalus; Types of Hemorrhage; Subarachnoid; Intracerebral; Intraventricular; Subdural; Prospective Human Drug Trials; Nimodipine; Nicardipine |
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TirilazadTissue Plasminogen Activator; Unruptured Aneurysms; Experimental Studies; In Vitro Pharmacological and Genetic Studies; In Vitro Physiological Studies; Animal Models; Liquid Blood Injections; Chronic Clot Application to Arteries; Drug Trials in Animals; Anatomical Observations; General; Musings from an Old World of Thought; History of Vasospasm Research in Japan: Commemoration of Professor Tomio Ohta; Dawn; Sunrise and Sunset; Heparin Treatment in Aneurysmal Subarachnoid Hemorrhage: A Review of Human Studies; Introduction; Heparin and Subarachnoid Hemorrhage; Complications of Heparin |
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ConclusionReferences; Subarachnoid Hemorrhage-Related Epilepsy; Introduction; The Epileptic Focus; Subarachnoid Hemorrhage-Related Epilepsy; AED Prophylaxis; Conclusion; References; Part I: Basic Science Section; Cell Culture Model to Study Cerebral Aneurysm Biology; Introduction; Vascular Smooth Muscle Cells; In Vitro VSMC Culture Model to Study CA Biology; Conclusions; References; Rat Model of Intracranial Aneurysm: Variations, Usefulness, and Limitations of the Hashimoto Model; Introduction; Animal Model of IAs; Special Insight in Some Modifiable Factors; BAPN; Strains |
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Ligation of Pterygopalatine ArteryLimitations; References; Possible Involvement of Caspase-Independent Pathway in Neuronal Death After Subarachnoid Hemorrhage in Mice; Introduction; Materials and Methods; SAH Modeling and Study Protocol; SAH Grade; Neurological Score; Histology; Cell Counting; Statistics; Results; Cleaved Caspase-3-Positive Neurons Appeared 24 h After SAH; Both Caspase-3-Related and Caspase-3-Unrelated Dying Neurons Were Observed After SAH; Discussion; References; Nox2 and Nox4 Participate in ROS-Induced Neuronal Apoptosis and Brain Injury During Ischemia-Reperfusion in Rats |
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IntroductionMaterials and Methods; Ethical Approval; Establishing the MCAO Model in Rats; Experimental Group and Drug Administration; Assay of ROS; TTC Staining; Ischemic Penumbra Dissection; Terminal Deoxynucleotidyl Transferase dUTP Nick End-Labeling (TUNEL) Staining and Fluoro-Jade B Staining; Western Blot Analysis; Statistical Analysis; Results; General Observation; Nox2 Inhibitor (gp91ds-tat) and Nox4 Inhibitor (GKT137831) Treatments Reduce ROS Levels in Brain Tissues of Rats After MCAO |
| Summary |
This book highlights the latest developments in acute and delayed neurovascular injury studies including delayed cerebral vasospasm, early brain injury, micro-circulation compromise, spreading cortical depolarization, neuroinflammation, and long-term cognitive dysfunctions after subarachnoid hemorrhage. About 32 chapters cover original presentations from the 14th international conference on neurovascular events after subarachnoid hemorrhage, held in Los Angeles in October 2017. Neurosurgeons, neurologists, and neuro-ICU practitioners discuss clinical observations, new pilot treatments, clinical trials, academic and industrial interactions, including surgical and endovascular approaches, brain injury monitoring, new developments in brain imaging, ICU management, early brain injury scales and management, counter cortical depolarization management and anti-inflammation management. In addition, animal models used to study acute and delayed neurovascular events, the basic mechanisms of vascular, neuronal, and CSF physiology, new experimental treatment strategies, new frontiers in the treatment of neurovascular injuries, and new research directions are discussed |
| Notes |
Gp91ds-tat and GKT137831 Treatments Reduce Cerebral Infarction Area at 24 h After Reperfusion in MCAO Rats |
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Includes indexes |
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Print version record |
| Subject |
Subarachnoid hemorrhage -- Congresses
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Subarachnoid Hemorrhage
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Subarachnoid hemorrhage
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| Genre/Form |
proceedings (reports)
|
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Conference papers and proceedings
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Conference papers and proceedings.
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Actes de congrès.
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| Form |
Electronic book
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| Author |
Martin, Robert D., editor.
|
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Boling, Warren W., editor.
|
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Chen, Gang, 1980 September- editor.
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Zhang, J. H. (John H.), editor.
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| ISBN |
9783030046156 |
|
303004615X |
|
3030046141 |
|
9783030046149 |
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