Description |
1 online resource (339 pages) |
Series |
RSC Drug Discovery |
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RSC drug discovery series.
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Contents |
Cover; Contents; Preface; Chapter 1 Introduction: The Five Ws of Pharmaceutical Green Chemistry; 1.1 Introduction; 1.2 What is Green Chemistry?; 1.3 Why Should the Pharmaceutical Industry Incorporate Green Chemistry?; 1.4 Who is Doing Green Chemistry?; 1.5 Where is Green Chemistry Being Applied?; 1.6 When Should Green Chemistry be Implemented?; 1.7 How is Green Chemistry Integrated into Drug Discovery?; References; Chapter 2 Barriers to Adopting Green Chemistry in Drug Discovery; 2.1 Introduction; 2.2 Economic Barriers; 2.2.1 Solvents; 2.2.2 Reagents |
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2.2.3 Recommendations for Overcoming Economic Barriers2.3 Technical Barriers; 2.3.1 Recommendations for Overcoming Technical Barriers; 2.4 Cultural Barriers; 2.4.1 Awareness of the 12 Principles within Drug Discovery; 2.4.2 Awareness of the 12 Principles in the Wider Chemistry Community; 2.4.3 Communication, within Drug Discovery and Beyond; 2.4.4 Definitions and Metrics; 2.4.5 Recommendations for Embedding a Green Chemistry Culture within Drug Discovery; 2.5 Opportunities; References; Chapter 3 Toward a Green Laboratory: One Reaction at a Time; 3.1 Introduction; 3.2 Synthetic Route Design |
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3.3 Planning Your Reaction3.3.1 Solvent Choices; 3.3.2 Reagent and Methodology Choices; 3.4 Reaction Setup; 3.5 Reaction Workup; 3.6 Purification and Waste; 3.7 Conclusion; References; Chapter 4 Greener Solvent Usage for Discovery Chemistry Analysis and Purification; 4.1 Introduction; 4.2 SFC versus HPLC for Chiral and Achiral Separations; 4.2.1 SFC Introduction; 4.2.2 SFC for Chiral Analysis/Purification; 4.2.3 SFC for Achiral Analysis/Purification; 4.3 Optimization of Analytical LC/MS Conditions for Reaction Monitoring/Final QC; 4.4 Optimizing Reverse Phase Purifications |
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4.5 Greener Solvent Alternatives and Solvent Reduction for Flash Purification4.5.1 Flash Purification Introduction; 4.5.2 Reduction of Organic Solvent Use During Silica Gel Chromatography; 4.5.3 Reducing Dichloromethane (DCM) Usage; 4.5.4 Measuring Progress in Solvent Reduction and DCM Replacement; 4.6 Flash SFC as Alternative to LC Based Flash Purification; 4.7 Conclusion; References; Chapter 5 Green Chemistry and High Throughput Screening; 5.1 Introduction; 5.2 Screening in Medicinal Chemistry; 5.3 Setting up a Reaction Screen; 5.3.1 Workflow of Screening |
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5.3.2 How Low Can You Go? Material Requirements5.3.3 Reaction Design -- Coverage of Chemical Space; 5.3.4 Strategies for Screening for Greener Solutions; 5.3.5 Data Capture, Analysis, and Visualization; 5.4 Case Studies in Reaction Screening; 5.4.1 Case Study 1 -- Amide Bond Formation; 5.4.2 Case Study 2 -- Suzuki Couplings; 5.5 Biotransformations; 5.6 Screening Gaseous/Heterogeneous Reactions; 5.7 Resolutions/Purifications and Purges; 5.8 Capturing Information/Conclusions; Acknowledgments; References; Chapter 6 Continuous Processing in Drug Discovery; 6.1 Introduction |
Summary |
A practical guide for academic and industrial chemists to incorporating Green Chemistry principles into the drug discovery discipline and its everyday workflows with maximum benefit |
Notes |
6.2 Green Process Strategies |
Bibliography |
Includes bibliographical references at the end of each chapters and index |
Notes |
English |
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Print version record |
Subject |
Pharmaceutical chemistry.
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Green chemistry.
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Drugs -- Design.
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Methodology.
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Pharmaceutical technology.
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Technology.
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Conservation of natural resources.
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Chemistry.
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Pharmacology.
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Physical sciences.
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Life sciences.
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Drug Design
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Combinatorial Chemistry Techniques
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Drug Discovery
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Green Chemistry Technology
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Methods
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Investigative Techniques
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Technology, Pharmaceutical
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Technology
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Chemistry, Pharmaceutical
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Conservation of Natural Resources
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Analytical, Diagnostic and Therapeutic Techniques and Equipment
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Technology, Industry, and Agriculture
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Chemistry
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Pharmacology
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Natural Science Disciplines
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Technology, Industry, Agriculture
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Biological Science Disciplines
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Disciplines and Occupations
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methodology.
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chemistry.
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pharmacology.
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physical sciences.
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biological sciences.
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Biochemistry.
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SCIENCE -- Life Sciences -- Biochemistry.
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SCIENCE -- Environmental Science (see also Chemistry -- Environmental)
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Green chemistry.
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Pharmaceutical chemistry.
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Form |
Electronic book
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Author |
Sneddon, Helen
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Shuster, Leanna
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Miller, Larry
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Richardson, Paul
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Gupton, B. Frank
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Budzinski, Kristi
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Richter, Daniel
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Clark, Alex
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Anastas, Nichloas
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Royal Society of Chemistry (Great Britain), Content Provider.
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ISBN |
9781782622659 |
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1782622659 |
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9781782625537 |
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1849739617 |
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9781849739610 |
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1782625534 |
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