| Description |
1 online resource |
| Contents |
Intro; Foreword; Preface; Contents; List of Contributors; 1: Molecular Virology and  Life Cycle; 1 Classification; 2 Structure of  the  Hepatitis B Virus; 2.1 Viral and  Subviral Particles; 2.2 Genome Organization and  Viral Proteins; 2.2.1 Pol ORF; 2.2.2 Pre-C/C ORF; HBc Protein; HBe Protein; 2.2.3 Pre-S/S ORF; SHBs; MHBs; LHBs; 2.2.4 X ORF; 3 Viral Life Cycle; 3.1 Attachment and  Penetration; 3.2 Conversion of  Genomic RC DNA into cccDNA and  Transcriptional Activation of  the  Viral Minichromosome; 3.3 Genomic Replication via Reverse Transcription |
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3.4 Virion Assembly and  Release4 Variant Viruses; 4.1 Precore Mutants; 4.2 Basal Core Promoter Mutants; 4.3 Polymerase Mutants; 4.3.1 l-Nucleoside Analogue Resistance; 4.3.2 Acyclic Nucleoside Phosphonate Resistance; 4.3.3 d-Cyclopentane Resistance; 4.3.4 Multidrug Resistance; 4.4 Envelope Mutants; References; 2: Unmet Needs in Basic Research: In Vitro and  In Vivo Models; 1 Introduction; 1.1 Hepatitis B Virus; 1.2 Woodchuck Hepatitis Virus; 1.3 Duck Hepatitis B Virus; 2 HBV In Vivo Experimental Models; 2.1 Chimpanzee Model; 2.2 Macaque Model; 2.3 Tupaia Model |
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2.4 Transgenic Mice2.5 Human Hepatocyte Chimeric Mice; 2.6 Immune-Competent Mouse Models; 2.7 Hydrodynamic Injection HBV Mouse Model; 2.8 Adenovirus-Mediated Delivery; 3 HBV In Vitro Experimental Systems; 3.1 Primary Human Hepatocytes; 3.2 HepG2 Cells; 3.3 HepaRG Cells; 3.4 HepCHLine-4 Cells; 3.5 Identification of  the  HBV Receptor; 3.6 NTCP Expression as a Limiting Factor for HBV Infection; 3.7 NTCP-Expressing Cell Lines; 3.8 Human Hepatocytes Isolated from  Humanized Mice; 3.9 Improvements to Primary Hepatocyte Culturing |
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3.10 Hepatic Cell Lines Derived from  Human-Induced Pluripotent Stem CellsReferences; 3: Immunopathogenesis of  Hepatitis B Virus (HBV) Infection; 1 Characteristics of  Immune Response in Acute-Resolved HBV Infection; 1.1 The Innate Immune Response; 1.1.1 HBV: Is It Sensed or Not by the  Innate Immune System?; 1.1.2 NK Cells: The Main Force of  Innate Immunity; 1.2 The Adaptive Immune Response; 1.2.1 B Cells; 1.2.2 T Cells; 2 Specialties of  the  Immune Response in Chronic HBV Infection; 2.1 The Innate Immune Response in CHB; 2.2 The Adaptive Immune Response in CHB |
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2.2.1 B Cells2.2.2 T Cells: Functional Exhaustion; 3 Immune Response and  Liver Injury; 3.1 HBV-Specific T Cells; 3.2 Non-HBV-Specific Cells; 4 Immune Response and  Antiviral Treatment; References; 4: Epidemiology and  Natural History of  Chronic Hepatitis B Virus Infection; 1 Introduction; 2 Epidemiology; 2.1 CHB in Africa; 2.2 CHB in Asia and  the  Pacific Islands; 2.3 CHB in the  Americas; 2.4 CHB in Europe; 3 HBV Genotypes; 4 Natural History; 5 Interpretation of  Serologies; 6 HBV Structure and  Replication Cycle; 7 Phases of  Infection; References |
| Summary |
This book provides a comprehensive, state-of-the art review of HBV infection and liver disease. It discusses new data on basic and translational medicine, including the viral life cycle, the immunopathogenesis of virus-induced chronic hepatitis, viral and host genetic factors affecting disease progression, and the mechanism of virus-induced hepatocarcinogenesis, as well as their potential applications in daily clinical practice. The clinical aspects of chronic HBV infection are examined in chapters on the global epidemiology, efficacy of HBV vaccination, natural history, co-infections with HCV, HDV or HIV, and management of special populations including children, pregnant women and patients undergoing immunosuppressive therapy. Further, it describes the advances and perspectives in the development of novel antiviral treatments as possible cures for HBV infection. The book is a valuable resource for medical students, physicians, and researchers who are interested in management of patients with chronic HBV infection and investigation HBV infection |
| Notes |
Includes index |
| Bibliography |
Includes bibliographical references at the end of each chapters and index |
| Notes |
Online resource; title from PDF title page (SpringerLink, viewed January 18, 2018) |
| Subject |
Hepatitis B virus.
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Liver -- Diseases.
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Hepatitis B.
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Hepatitis B
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Hepatitis B virus
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HEALTH & FITNESS -- Diseases -- General.
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MEDICAL -- Clinical Medicine.
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MEDICAL -- Diseases.
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MEDICAL -- Evidence-Based Medicine.
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MEDICAL -- Internal Medicine.
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Hepatitis B
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Hepatitis B virus
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Liver -- Diseases
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| Form |
Electronic book
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| Author |
Kao, Jia-Horng, editor
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Chen, Ding-Shinn, editor
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| ISBN |
9789811048432 |
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9811048436 |
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9811048428 |
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9789811048425 |
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9789811048449 |
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9811048444 |
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9789811352454 |
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9811352453 |
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