| Description |
1 online resource (xvi, 176 pages) |
| Contents |
Imaging of Dopaminergic Neurons and the Implications for Parkinson's Disease / Wakoto Matsuda -- Modelling and Simulation of Brain Energy Metabolism: Energy and Parkinson's Disease / Peter Wellstead and Mathieu Cloutier -- Systems Biology of Aging: Opportunities for Parkinson's Disease / Andres Kriete -- Mitochondrion- and Endoplasmic Reticulum-Induced SK Channel Dysregulation as a Potential Origin of the Selective Neurodegeneration in Parkinson's Disease / Guillaume Drion, Vincent Seutin and Rodolphe Sepulchre -- Energetics of Ion Transport in Dopaminergic Substantia nigra Neurons / Febe Francis, Míriam R. García and Richard H. Middleton -- Real-Time In Vivo Sensing of Neurochemicals / Fiachra B. Bolger, Niall J. Finnerty and John P. Lowry -- Modeling Protein and Oxidative Metabolism in Parkinson's Disease / Mathieu Cloutier and Peter Wellstead -- Mathematical Models of Dopamine Metabolism in Parkinson's Disease / Zhen Qi, Gary W. Miller and Eberhard O. Voit |
| Summary |
This text is the first to present a study of Parkinson's disease from a Systems Biology perspective. By placing the condition at centre stage, the authors have been able to provide a wide ranging modelling and systems analysis that is focussed on a multi-facetted and highly complex condition. The book comprises a specially selected set of eight studies of important aspects of PD, covering all relevant scales of space and time. These are used to show how innovative sensing techniques, mathematical modelling, model analysis and computational simulation can throw new light on the dynamics of disease mechanisms that drive this important form of neurodegeneration |
| Analysis |
Life sciences |
|
Medicine |
|
Neurosciences |
|
Biological models |
|
Systems Biology |
|
Biomedicine general |
| Bibliography |
Includes bibliographical references and index |
| Subject |
Parkinson's disease -- Simulation methods
|
|
Systems biology.
|
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Parkinson Disease
|
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Systems Biology
|
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HEALTH & FITNESS -- Diseases -- Alzheimer's & Dementia.
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MEDICAL -- Neurology.
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Systems biology
|
| Form |
Electronic book
|
| Author |
Wellstead, P. E
|
|
Cloutier, Mathieu
|
| ISBN |
9781461434115 |
|
1461434114 |
|
1461434106 |
|
9781461434108 |
|
