Causality in medicine / Giulio Giorello -- The evolution of the biomedical paradigm in oncology : implications for cancer therapy / Gilberto Corbellini and Chiara Preti -- Anticancer drug discovery and development / Francesco Colotta -- Beyond VEGF : targeting tumor growth and angiogenesis via alternative mechanisms / James Christensen and Kenna Anderes -- Aurora kinases and their inhibitors : more than one target and one drug / Patrizia Carpinelli and Jürgen Moll -- Signalling pathways and adhesion molecules as targets for antiangiogenesis therapy in tumors / Gianfranco Bazzoni -- Developing T-cell therapies for cancer in an academic setting / Malcolm K. Brenner -- Anticancer cell therapy with TRAIL-armed CD34 progenitor cells / Carmelo Carlo-Stella [and others] -- Linking inflammation reactions to cancer : novel targets for therapeutic strategies / Alberto Mantovani [and others] -- Clinical development of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors : what lessons have we learned? / Manuel Hidalgo -- GIST as the model of paradigm shift towards targeted therapy of solid tumors : update and perspective on trial design / Jaap Verweij, Caroline Seynaeve, and Stefan Sleijfer -- Monoclonal antibodies in the treatment of malignant lymphomas / Bertrand Coiffier -- Molecular network analysis using reverse phase protein microarrays for patient tailored therapy / Runa Speer [and others]
Summary
In September 2005 an International Meeting on "Targeted Therapies in Cancer: Myth or Reality" was held in Milan. This book collects the contributions given by scientists and clinicians, from Academia and Industry, who participated to this Meeting. It provides an overview of diverse approaches ranging from drug discovery to cellular therapy