Description |
1 online resource |
Series |
Springer theses |
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Springer theses.
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Contents |
Introduction -- Gold(I)-Catalyzed Reactions of 1,6-Enynes with Aldehydes: Cycloaddition Versus Metathesis-Type Reactions -- Formation of Cyclobutene Compounds via Gold(I)-Catalyzed Cycloisomerization of 1,n-Enynes -- Approach Toward the Total Synthesis of Lundurines -- Summary and Outlook |
Summary |
Ana Escribano Cuesta's thesis presents a detailed study of the inter- and intramolecular reactions of carbonyl compounds with 1,6-enynes using gold (I) complexes. An important part of the work involved streamlining the variables that allow the selective synthesis of different products such as tricyclic compounds, dihydropyrans, 1,3-dienes or cyclobutenes. The second chapter highlights the importance and difficulties in synthesising a cyclobutene subunit and the author includes a detailed description of how the products were prepared. The final chapter outlines the synthesis of lundurines using methodology developed by the author's research group for intramolecular gold-catalyzed cyclization of indoles with alkynes. The lundurine products developed in this work show significant in vitro cytoxicity toward B16 melanoma cells. The work in this thesis has led to a number of publications in high-profile chemistry journals |
Analysis |
chemie |
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chemistry |
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organometaalverbindingen |
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organometallic compounds |
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organische scheikunde |
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organic chemistry |
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katalyse |
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catalysis |
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Chemistry (General) |
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Chemie (algemeen) |
Notes |
Ph. D. Institute of Chemical Research of Catalonia 2013 |
Bibliography |
Includes bibliographical references |
Notes |
Print version record |
Subject |
Metal catalysts.
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Gold.
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Gold
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teocuitlatl.
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gold (metal)
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SCIENCE -- Chemistry -- Physical & Theoretical.
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Chimie.
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Science des matériaux.
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Gold
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Metal catalysts
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Genre/Form |
dissertations.
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Academic theses
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Academic theses.
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Thèses et écrits académiques.
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Form |
Electronic book
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ISBN |
9783319007021 |
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3319007025 |
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3319007017 |
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9783319007014 |
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