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Author Cuesta, Ana Escribano, author

Title New gold-catalyzed reactions and applications for the synthesis of alkaloids / Ana Escribano Cuesta
Published Cham : Springer, [2013]
©2013

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Description 1 online resource
Series Springer theses
Springer theses.
Contents Introduction -- Gold(I)-Catalyzed Reactions of 1,6-Enynes with Aldehydes: Cycloaddition Versus Metathesis-Type Reactions -- Formation of Cyclobutene Compounds via Gold(I)-Catalyzed Cycloisomerization of 1,n-Enynes -- Approach Toward the Total Synthesis of Lundurines -- Summary and Outlook
Summary Ana Escribano Cuesta's thesis presents a detailed study of the inter- and intramolecular reactions of carbonyl compounds with 1,6-enynes using gold (I) complexes. An important part of the work involved streamlining the variables that allow the selective synthesis of different products such as tricyclic compounds, dihydropyrans, 1,3-dienes or cyclobutenes. The second chapter highlights the importance and difficulties in synthesising a cyclobutene subunit and the author includes a detailed description of how the products were prepared. The final chapter outlines the synthesis of lundurines using methodology developed by the author's research group for intramolecular gold-catalyzed cyclization of indoles with alkynes. The lundurine products developed in this work show significant in vitro cytoxicity toward B16 melanoma cells. The work in this thesis has led to a number of publications in high-profile chemistry journals
Analysis chemie
chemistry
organometaalverbindingen
organometallic compounds
organische scheikunde
organic chemistry
katalyse
catalysis
Chemistry (General)
Chemie (algemeen)
Notes Ph. D. Institute of Chemical Research of Catalonia 2013
Bibliography Includes bibliographical references
Notes Print version record
Subject Metal catalysts.
Gold.
Gold
teocuitlatl.
gold (metal)
SCIENCE -- Chemistry -- Physical & Theoretical.
Chimie.
Science des matériaux.
Gold
Metal catalysts
Genre/Form dissertations.
Academic theses
Academic theses.
Thèses et écrits académiques.
Form Electronic book
ISBN 9783319007021
3319007025
3319007017
9783319007014