Title Spectroscopic and mechanistic studies of dinuclear metallohydrolases and their biomimetic complexes / Lena Josefine Daumann

Published Cham : Springer, 2014

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Description 1 online resource (xxi, 239 pages) : illustrations (some color) Series Springer theses, 2190-5053 Springer theses, 2190-5053 Contents From the Contents: Introduction -- Experimental -- Understanding the Overall Structure of GpdQ and Metal Binding -- Structural and Mechanistic Studies of Zn(II) Complexes as Phosphoesterase Models Summary Lena Daumanns's thesis describes structural and functional studies of the enzyme Glycerophosphodiesterase (GpdQ) from Enterobacter aerogenes. It also examines the properties of small mimics of this enzyme and related binuclear metallohydrolases such as the metallo-ß-lactamases to enhance our understanding of hydrolytic cleavage of important substrates like phosphoesters and c-lactams. Overall, this project has led to a better understanding of the metal ion binding and active site structural features of the enzyme GpdQ. Daumann describes how she successfully immobilized phosphoesterase and related biomimetics on solid supports for potential applications in the area of bioremediation of organophosphate pesticides. Analysis shows that both the enzyme and biomimetics can be stored on the solid support without loss of activity. Furthermore, the author specroscopically and mechanistically characterized a number of Zn(II), Cd(II) and Co(II) complexes, some of which are among the most active biomimetics towards organophosphates reported to date. This thesis makes excellent reading for non-specialists because each chapter includes a short introduction section Notes "Doctoral thesis accepted by University of Queensland, Australia." Bibliography Includes bibliographical references Notes Online resource; title from PDF title page (SpringerLink, viewed June 10, 2014) Subject Enzymes -- Synthesis. Enzymology. Biomimetics. Biomimetics SCIENCE -- Life Sciences -- Biochemistry. Biomimetics Enzymes -- Synthesis Enzymology Form Electronic book ISBN 9783319066295 3319066293 3319066285 9783319066288

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