Part Part I: Xenobiotics and Soluble Receptors -- chapter 1 The Ah Receptor Signal Transduction Pathw ay -- chapter 2 The Peroxisome Proliferator-Activated Receptor: An Orphan Receptor in Xenobiotica Response / Martin Gottlicher -- chapter 3 Effects of Xenobiotics on Hormone Receptors / Debie J. Hoivik -- chapter 4 Interactions Between Environmental Xenobiotics and Estrogen Receptor-Mediated Responses / Daniel L. Villeneuve -- part Part II: Xenobiotics and Transcription Factors -- chapter 5 Barbiturate-Inducible Gene Expression / Armand J. Fulco -- chapter 6 Antioxidant-Inducible Detoxifying Enzyme Gene Expression / Anil K. Jaiswal -- chapter 7 Mechanism of Heavy Metal-Inducible Gene Transcription / Fuminori Otsuka -- part Part III: Xenobiotics and Second Messenger Systems -- chapter 8 Modulation of Protein Kinases by Xenobiotics -- chapter 9 Cellular Calcium Regulation and Signaling -- part Part IV: Analysis of Xenobiotic-Inducible Responses -- chapter 10 Approaches for the Identification of Xenobiotic-Inducible Genes / JohnP. VandenHeuvel
Summary
Many of the toxic effects elicited by xenobiotics can be explained at the molecular level by their interaction with receptors or by disruption or interference with receptor-mediated signal transduction pathways. This volume describes molecular approaches and reviews of current research. It provides reviews of numerous research areas which are directly related to the analysis of the molecular mechanism by which xenobiotics modulate signal transduction and gene expression