| Description |
1 online resource |
| Series |
Progress in inflammation research |
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PIR (Series)
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| Contents |
General Introduction to Barrier Mechanisms in the Central Nervous System; 1 Introduction; 2 Barriers of the Brain; 3 Cellular Components of the Neurovascular Unit; 4 Influx Mechanisms of the Blood-Brain Barrier; 5 Efflux Mechanisms of the Brain Barrier Interfaces; 6 Brain Barriers Regulate CSF Secretion; 7 Conclusion; References; Topological Aspects of the Blood-Brain and Blood-Cerebrospinal Fluid Barriers and Their Relevance in Inflammation; 1 Introduction; 2 Brain Inflammation in Human Diseases and Animal Models; 2.1 Multiple Sclerosis |
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2.2 An Animal Model for MS: Experimental Autoimmune Encephalomyelitis2.3 Lymphocyte Entry into the CNS; 2.4 BBB Permeability During CNS Inflammation; 2.5 Cortical Inflammation in MS; 2.6 The Two-Wave Model for Lymphocyte Entry; 2.7 Neuromyelitis Optica; 3 Topology of the Blood-Brain and Blood-Cerebrospinal Fluid Barriers; 3.1 The Endothelial Side of the Barrier; 3.2 The Glial Side of the Barriers; 3.3 Water Movements in the Brain; 4 Barrier-Related Cellular Characteristics of Epithelial Cells of the Choroid Plexus and Vascular Endothelial Cells During Inflammation; 5 Conclusions; Literature |
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The Contribution of the Extracellular Matrix to the BBB in Steady State and Inflammatory Conditions1 The Blood-Brain Barrier; 2 The Extracellular Matrix of the CNS; 3 Laminin Receptors on Endothelium and Astrocyte Endfeet; 4 Contributions of the Basement Membranes to BBB integrity; 4.1 Genetic Defects; 4.2 Autoimmune Diseases; 4.2.1 Leukocyte Transmigration Across the Endothelial BM; 4.2.2 Leukocyte Transmigration Across the Parenchymal BM; 5 Conclusion; References; Pathophysiology of the Blood-Brain Barrier in Neuroinflammatory Diseases; 1 Introduction; 2 Multiple Sclerosis |
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2.1 Alzheimer's Disease3 Amyotrophic Lateral Sclerosis; 3.1 Parkinson's Disease; 3.2 Huntington's Disease; 4 Conclusion; References; Leakage at Blood-Neural Barriers; 1 Rationale; 2 Measuring Vascular Permeability; 3 Basal Water and Solute Transport at Blood-Neural Barriers; 4 Pathophysiological Leakage; 5 The Paracellular Leakage Pathway; 6 The Transcellular Leakage Pathway; 7 Endothelial Signalling During BBB or BRB Leakage; 8 BBB/BRB Function and Dysfunction: Nature and Nurture; 9 Opening the BBB for Therapeutic Drug Delivery; 10 Conclusion; References |
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Blood-Brain Barrier Transporters and Neuroinflammation: Partners in Neuroprotection and in Pathology1 Introduction; 2 BBB Transporter Proteins; 2.1 ATP-Binding Cassette Transporters; 2.1.1 Subfamily A Member: CERP (ABCA1); 2.1.2 Subfamily B Member: MDR1/P-gp (ABCB1); 2.1.3 Subfamily C, Members: MRP1 (ABCC1) and MRP4 (ABCC4); 2.1.4 Subfamily G, Member BCRP (ABCG2); 2.2 Solute Carrier Transporters; 2.2.1 SLC2: Facilitative Glucose Transporter Family Member: GLUT1 (SLC2A1); 2.2.2 SLC7A-SLC3A2: Neutral Amino Acid Transporter (LAT1-4F2hc) |
| Summary |
Within the central nervous system (CNS) the constantly changing blood stream is separated from the CNS parenchyma by the blood brain barrier (BBB) restricting passage to selected immune cells. Under pathological conditions, however, viruses, bacteria, parasites and autoaggressive immune cells can penetrate the barrier and contribute to CNS inflammation. The BBB actively contributes to neuroinflammation by presentation of chemokines, expression of cell adhesion molecules and alteration of barrier properties. As such, understanding the role of the BBB under healthy and pathological conditions is essential for the development of new drugs to efficiently combat inflammatory diseases of the CNS. This book presents a comprehensive collection of reviews that focus on the role of the BBB. Experts in the field share their insight on structural, topological and functional properties of the BBB. They elaborate on pathophysiological changes of the inflamed BBB such as permeability, transporter proteins and alterations in microRNAs and cytokine profile. Additional chapters on multiple sclerosis and bacterial meningitis provide in depth information on significant neuroinflammatory diseases. The selection is complemented by a review on the current understanding of the BBB as signaling hub in tumor pathogenesis in the brain |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Online resource; title from PDF title page (EBSCO, viewed April 5, 2017) |
| Subject |
Blood-brain barrier.
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Inflammation.
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Neurosciences.
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Cellular biology (cytology)
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Infectious & contagious diseases.
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Immunology.
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SOCIAL SCIENCE -- Anthropology -- Physical.
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Blood-brain barrier
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Inflammation
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| Form |
Electronic book
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| Author |
Lyck, Ruth, editor
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Enzmann, Gaby, editor
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| ISBN |
9783319455143 |
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3319455141 |
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