| Description |
1 online resource |
| Contents |
Cover; Half Title ; Title Page ; Copyright Page ; Table of Contents ; Preface ; Editors ; Contributors ; Chapter 1: Microbial Genome Mining for Natural Product Drug Discovery ; 1.1 Introduction ; 1.1.1 Importance of Natural Products and the Issue of Rediscovery |
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1.1.2 Genome Mining Enhances Discovery and Circumvents Rediscovery 1.1.3 Scope of the Chapter ; 1.2 The New Central Dogma of Genome Mining ; 1.2.1 What Is Genome Mining and Why Is It Important? ; 1.2.2 What Are the Drivers for Successful Genome Mining? ; 1.2.2.1 Primary Drivers |
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1.2.2.1.1 Microbes Gifted for Natural Product Biosynthesis 1.2.2.1.1.1 Actinomycetes ; 1.2.2.1.1.2 Other Culturable Bacteria ; 1.2.2.1.1.3 Culturable Archaea ; 1.2.2.1.1.4 Uncultured Bacteria and Archaea ; 1.2.2.1.1.5 Historical Record ; 1.2.2.1.2 DNA Sequencing Technology |
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1.2.2.1.3 Methods to Activate Expression of Cryptic SM Pathways 1.2.2.1.3.1 Fermentation Optimization ; 1.2.2.1.3.2 Genetic Manipulations ; 1.2.2.2 Secondary Drivers ; 1.2.2.2.1 Bioinformatics ; 1.2.2.2.1.1 antiSMASH ; 1.2.2.2.1.2 PRISM ; 1.2.2.2.1.3 MIBiG ; 1.2.2.2.1.4 IMG-ABC |
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1.2.2.2.2 Metabolomics 1.2.2.2.3 Enzyme Structural Biology and Function ; 1.2.3 Strategies and Tactics for Genome Mining ; 1.2.3.1 Mining Individual Microbes ; 1.2.3.1.1 Streptomyces avermitilis ; 1.2.3.1.2 Streptomyces coelicolor ; 1.2.3.1.3 Streptomyces ambofaciens |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| Subject |
Pharmacognosy.
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Natural products.
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Pharmacognosy
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Biological Products -- chemistry
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MEDICAL -- Pharmacology.
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Natural products
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Pharmacognosy
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| Form |
Electronic book
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| Author |
Newman, David J., 1939-
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Cragg, Gordon M. L
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Grothaus, Paul
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| ISBN |
9781315117089 |
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1315117088 |
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1351643282 |
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9781351643283 |
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9781439841945 |
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1439841942 |
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