| Description |
1 online resource : illustrations, map |
| Contents |
Front Cover; Implementing Precision Medicine in Best Practices of Chronic Airway Diseases; Copyright Page; Contents; List of Contributors; Foreword; I. The Concept of Precision Medicine and Precision Health; 1 The Audacious Goal of Precision Medicine; Further Reading; 2 Critical Entry Points-Genetics and Epigenetics; Critical Entry Points-Genetics and Epigenetics; Genetics: An Overview; Genetics of CRS; Epigenetics in CRS; Clinical Uses of Genetics and Genotyping in CRS; Characterization of Unexplained Immune Deficiencies; Assessment and Selection of Therapy for Cystic Fibrosis |
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Predictive GeneticsTaste Receptors; Staphyloccus aureus Carriage in CRSwNP; Summary and Future Perspectives; 3 Critical Entry Points-Microbiome; Introduction; Microbiome Evolution in Early Life; Microbiome-Host Mechanisms; Microbiome in Asthma Patients; Microbiome in Allergic Rhinitis and Chronic Rhinosinusitis; Microbiome in Precision Medicine; Conclusions; References; 4 Factors Modulating the Disease Endotype; The complex immune-inflammatory network driving the endotype; The relation with the remodeled phenotype; The epigenetic influences; The role of the exposome |
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Metabolic and endocrine pathwaysNeuroimmune factors; Conclusion; References; 5 Revised Disease Nomenclature Including Disease Endotypes; Introduction; Endotypes of Allergic Diseases; New Approach to Nomenclature; Asthma Endotypes; References; II. Shortcomings of Current Care Pathways for Chronic Airways Diseases; 6 The Global Burden of Chronic Airway Diseases; Introduction; References; 7 Unmet Needs in Chronic Upper Respiratory Tract Diseases; General Principles; Defining Patient Subpopulations; Etiology and Pathophysiology; Guidelines and Consensus Documents; Treatment; Conclusion |
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Key PointsReferences; III. Personalized care: endotype-driven treatment; 8 Endotype-Driven Approach for Asthma; Asthma Phenotypes and Endotypes; Type-2 Asthma Endotype; Non-Type-2 Asthma Endotype; Conclusions; References; 9 Endotype-Driven Approach for Chronic Rhinosinusitis; Abbreviations; Introduction; Endotypes Based on T-Helper Cells; Endotyping of CRS; Treatment Approaches to Endotypes; Conclusion; Source of Funding; References; 10 Endotype-Driven Approach in Rhinitis; References; 11 Prevention of Allergies; Abbreviations; Introduction and Epidemiology; Primary Prevention |
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Secondary PreventionTertiary Prevention; Risk Factors and Protective Factors; Genetic and Epigenetic Aspects; Family History and Allergy Susceptibility Genes; Epigenetic Regulation in Allergic Disease; Environmental Aspects; Siblings and Day Nursery; Farm Effect; Nutrition and Breastfeeding; Cesarean Section; Indoor Air; Pets; Outdoor Air Pollution; Climate Change; Occupational Allergies; Consequences for Allergy Prevention; Do's and Don'ts of Allergy Prevention; Research Needs and Outlook; Individualized Prevention; References; 12 Prevention of Asthma |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Online resource; title from PDF title page (ScienceDirect, viewed September 26, 2018) |
| Subject |
Respiratory organs -- Diseases.
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Respiratory Tract Diseases
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MEDICAL -- Pulmonary & Thoracic Medicine.
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Respiratory organs -- Diseases
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| Form |
Electronic book
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| Author |
Agache, Ioana, editor.
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Hellings, Peter W., editor.
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| ISBN |
9780128134726 |
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0128134720 |
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