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Book Cover
E-book
Author Jakubowski, Hieronim

Title Homocysteine in protein structure/function and human disease : chemical biology of homocysteine-containing proteins / Hieronim Jakubowski
Published Vienna ; New York : Springer, ©2013

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Description 1 online resource
Contents Introduction -- An Overview of Homocysteine Metabolism -- Homocysteine-Thiolactone -- Discoveries of Protein S- and N-Homocysteinylation -- N-Homocysteinyl-Proteins -- Pathophysiological Consequences of Protein N-Homocysteinylation -- S-Homocysteinylated Proteins
Summary Excess of homocysteine, a product of the metabolism of the essential amino acid methionine, is associated with poor health, is linked to heart and brain diseases in general human populations, and accelerates mortality in heart disease patients. Neurological and cardiovascular abnormalities occur in patients with severe genetic hyperhomocysteinemia and lead to premature death due to vascular complications. Although it is considered a non-protein amino acid, studies over the past dozen years have discovered mechanisms by which homocysteine becomes a component of proteins. Homocysteine-containing proteins lose their normal biological function and become auto-immunogenic and pro-thrombotic. In this book, the author, a pioneer and a leading contributor to the field, describes up-to date studies of the biological chemistry of homocysteine-containing proteins, as well as pathological consequences and clinical implications of their formation. This is a comprehensive account of the broad range of basic science and medical implications of homocysteine-containing proteins for health and disease
Analysis Life sciences
Metabolic diseases
Biochemistry
Protein Structure
Protein Science
Medical Biochemistry
Bibliography Includes bibliographical references and index
Notes Online resource; title from PDF title page (SpringerLink, viewed July 1, 2013)
Subject Homocysteine.
Homocysteine
MEDICAL -- Biochemistry.
Homocysteine
Form Electronic book
ISBN 9783709114100
3709114101
3709114098
9783709114094