| Description |
1 online resource (viii, 166 pages) : illustrations (some color) |
| Contents |
Intro; Preface; Contents; 1: Reconstitution of Germ Cell Development In Vitro; 1.1 Introduction; 1.2 In Vitro Reconstitution of Mouse Germ Cell Development; 1.2.1 Signaling Pathways for the Specification of Mouse Primordial Germ Cells; 1.2.2 Induction of PGC-Like Cells (PGCLCs) from Mouse Pluripotent Stem Cells; 1.2.3 Completion of Mouse Oogenesis In Vitro; 1.2.4 Induction of Spermatogonia-Like Cells from PGCLCs; 1.2.5 Propagation of PGCLCs In Vitro; 1.3 Induction of Human Germ Cell Fate In Vitro; 1.3.1 In Vitro Systems to Induce Human PGCLCs from hPSCs |
|
1.3.2 Competence for the Induction of Human PGCLCs1.4 Future Perspectives for Reconstituting Human Germ Cell Development In Vitro; References; 2: The Role of Hedgehog-BMP4 Signaling in the Patterning of Coelomic Mesoderm and the Onset of Gonadogenesis; 2.1 Introduction; 2.1.1 Contrasting Cellular Behaviors in the Dorsal and Ventral Parts of Medial LPM at the Onset of Gonadogenesis; 2.1.2 Hedgehog (Hh) Signaling Establishes Dorsoventral Pattern in M-LPM and Initiates Gonadogenesis; 2.1.3 Dynamic Transition of BMP4 Expression and Roles at the Downstream of Hh Signaling in LPM |
|
2.1.4 Candidate Molecules Regulating Cellular Behaviors Involved in the Onset of Gonadogenesis Downstream of Hh-BMP4 SignalingReferences; 3: Regulation of Metabolic Pathways in Steroidogenic Cells by Ad4BP/SF-1; 3.1 Introduction; 3.1.1 Metabolic Pathways Activated in Steroidogenic Cells; 3.1.2 Implication of Ad4BP/SF-1 into Glycolytic Gene Regulation; 3.1.3 Implication of Ad4BP/SF-1 into NADPH Synthetic Gene Regulation; 3.1.4 Orchestration of Metabolic Pathways by a Single Transcription Factor; References |
|
4: Role of Lgr5-Expressing Stem Cells in Epithelial Renewal and Cancer in the Reproductive Tract4.1 Introduction; 4.2 Methods Employed to Identify and Characterise Reproductive Epithelial Stem Cells; 4.3 Lgr5+ Stem Cell Precursors Give Rise to Adult OSE and Cortical Granulosa Lineages; 4.4 Regulation of Lgr5+ Stem Cell-Driven OSE Regeneration: Intrinsic Versus Niche Signals; 4.5 Cancer of the Reproductive Tract: Lgr5+ OSE Stem Cells as Ovarian Cancer Origins; 4.6 Future Directions and Conclusion; References; 5: Tumor-Initiating Cells in Ovarian Cancer; 5.1 Introduction |
|
5.2 Stem Cells in the Normal Ovary and in Ovarian Cancer5.3 Redefining Reversible Quiescence as a Functional Property of CSCs Reappropriated Their Recognition as Tumor-Initiating Cells (TICs); 5.4 CSC/TIC Identification Through the Maze of Intra-Tumor Heterogeneity and Their Differential Regulation Under Conditions of Stress; 5.5 Future Perspectives; References; 6: Emerging Role of CD44 Variant 6 in Driving the Metastatic Journey of Ovarian Cancer Stem Cells; 6.1 Introduction; 6.2 Genomic and Protein Structure of CD44; 6.3 CD44 and Cancer Stemness |
| Summary |
This unique compilation focuses on a very curious organ, the ovary. There are still many unknown facts about the origins of ovarian tissue and ovarian cancer, and each chapter describes in detail the latest insights into the ovary from basic to clinical aspects. Expert authors reveal the most recent findings on ovariogenesis and ovarian carcinogenesis by shedding light on stem cell biology for the ovarian surface epithelial cells or primordial germ cells. Readers will greatly increase their understanding of the relevance of the cells that constitute the ovary, which is of vast significance in comprehending the occurrence mechanism of ovarian tissue and ovarian cancer. In this way the book covers a wide range of fields concerned with the ovary. This work benefits not only gynecologists and obstetricians, but also basic researchers in the field of stem cell biology and all clinicians who are involved in the management of fertility preservation or ovarian cancer |
| Notes |
Online resource; title from PDF title page (SpringerLink, viewed May 14, 2018) |
| Subject |
Ovaries.
|
|
Ovary
|
|
SOCIAL SCIENCE -- Anthropology -- Physical.
|
|
Ovaries
|
| Form |
Electronic book
|
| Author |
Katabuchi, Hidetaka, editor
|
|
Ohba, T. (Takeshi), editor.
|
|
Motohara, Takeshi, editor
|
| ISBN |
9789811079412 |
|
9811079412 |
|
