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Book Cover
E-book
Author Coenen, Heinz H.

Title Radioionidation reactions for radiopharmaceuticals : compendium for effective synthesis strategies / by Heinz H. Coenen, John Mertens and Bernard Mazière ; with contributions from Peter Bläuenstein [and others]
Published Dordrecht : Springer, 2006

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Description 1 online resource (xi, 101 pages) : illustrations
Contents Cover -- TABLE OF CONTENTS -- 1 Introduction -- 1.1 Authentic Labelling -- 1.2 Labelling with Metallic Radioisotopes -- 1.3 Labelling Methods for Radioiodine -- 2 Iodine Radionuclides -- 2.1 Physical Properties and Areas of Application -- 2.2 Radiochemical and Radionuclidic Purity -- 2.3 Specific Radioactivity -- 2.4 Production of Iodine Radionuclides -- 2.4.1 Production of [sup(120)]I -- 2.4.2 Production of [sup(122)]I -- 2.4.3 Production of [sup(123)]I -- 2.4.4 Production of [sup(124)]I -- 2.4.5 Production of [sup(125)]I -- 2.4.6 Production of [sup(131)]I -- 2.5 References -- 3 Iodinated Radiopharmaceuticals -- 3.1 Physico-chemical Properties -- 3.1.1 Carbon-iodine bond -- 3.1.2 Lipophilicity -- 3.2 Pharmaceutical Properties -- 3.2.1 Chemical and Radiochemical Purity -- 3.2.2 Stability In Vitro and Shelf-life -- 3.2.3 Pharmacological Characteristics -- 3.2.4 Pharmaceutical Considerations -- 3.3 References -- 4 Methods of Radioiodination -- 4.1 Nucleophilic Substitution -- 4.1.1 General -- 4.1.2 Halogen Exchange in Aliphatic Compounds -- 4.1.3 Halogen Exchange in Aromatic Compounds -- 4.1.4 Copper-assisted Halogen Exchange -- 4.1.5 Radioiodo-dediazonisation -- 4.1.6 References -- 4.2 Electrophilic Substitution -- 4.2.1 General Considerations -- 4.2.2 Oxidising Reagents -- 4.2.3 Direct Electrophilic Radioiodination (Radioiodo-deprotonation) -- 4.2.4 Demetallation Techniques (Radioiodo-demetallation) -- 4.2.5 References -- 4.3 Macromolecule Labelling -- 4.3.1 Protein Radioiodination -- 4.3.2 Oligonucleotide Radioiodination -- 4.3.3 References -- 5 Iodinated Radiopharmaceuticals -- 5.1 Examples of Nucleophilic Labelling -- 5.1.1 Interhalogen Exchange -- 5.1.2 Other Methods -- 5.2 Examples of Electrophilic Labelling -- 5.2.1 Direct Iodination -- 5.2.2 Radioiodo-demetallation -- 5.3 References -- 6 Expert System -- 6.1 General Considerations -- 6.2 Activating Effects of Aromatic Substituents -- 6.2.1 Aromatic Nucleophilic Substitution (SN[sub(Ar)]) -- 6.2.2 Aromatic Electrophilic Substitution (SE[sub(Ar)]) -- 7 Guidelines for Radioiodination -- 7.1 Introduction -- 7.1.1 Reactivity of the Aromatic Ring -- 7.2 Examples -- 7.2.1 Compound: R91150 -- 7.2.2 Compound: IBZM -- 7.3 Blank Checklist -- Last Page
Summary "Molecules of biological interest for in-vivo and in-vitro research or diagnostics of metabolic functions and of neuro-transmission are very often labeled with iodine. Based on state-of-the-art research, this compendium describes the major production routes of the six most relevant iodine radio isotopes and the various methods of labeling molecules of biological, diagnostic or pharmaceutical interest with them. The chapters describe the basic reaction mechanisms, and the influence of iodine introduction on physical/chemical and pharmacological properties. They also include examples of important reaction pathways for the preparation of radio-iodine compounds. The volume is completed by an expert system providing guidelines to obtain the most suitable method of synthesis regarding also cost and time aspects. Worked examples support the novices confronted with radioionidation reactions."--Jacket
Analysis chemie
chemistry
geneeskunde
medicine
fysische chemie
physical chemistry
analytische scheikunde
analytical chemistry
organische scheikunde
organic chemistry
Chemistry (General)
Chemie (algemeen)
Bibliography Includes bibliographical references
Notes Print version record
Subject Radiopharmaceuticals -- Synthesis -- Handbooks, manuals, etc
Drugs -- Effectiveness -- Handbooks, manuals, etc
Radioactive tracers.
Single-photon emission computed tomography.
Iodine Radioisotopes -- chemistry
Iodine Radioisotopes -- therapeutic use
Radioactive Tracers
Radiopharmaceuticals -- radiation effects
Tomography, Emission-Computed, Single-Photon
PSYCHOLOGY -- Psychotherapy -- General.
Drugs -- Effectiveness.
Iodine Radioisotopes -- chemistry.
Iodine Radioisotopes -- therapeutic use.
Radioactive tracers.
Radiopharmaceuticals -- radiation effects.
Tomography, Emission-Computed, Single-Photon.
Radiopharmaceuticals -- Synthesis.
Chimie.
Science des matériaux.
Single-photon emission computed tomography
Radioactive tracers
Drugs -- Effectiveness
Genre/Form handbooks.
Handbooks and manuals
Handbooks and manuals.
Guides et manuels.
Form Electronic book
Author Mertens, John, 1945-
Mazière, Bernard.
ISBN 9781402045615
1402045611
1402045603
9781402045608
1280625104
9781280625107
6610625107
9786610625109
Other Titles Radioionidation reactions for pharmaceuticals