| Description |
1 online resource |
| Series |
Chapman & Hall/CRC Biostatistics Series |
|
Chapman & Hall/CRC biostatistics series
|
| Contents |
Front Cover; Contents; Preface; Chapter 1: Introduction; Chapter 2: Choice of Noninferiority Margin for the Mean Difference; Chapter 3: Choice of Noninferiority Margin for the Mean Ratio and Hazard Ratio; Chapter 4: Noninferiority Hypotheses with Binary Endpoints; Chapter 5: Two Statistical Approaches for Testing the Noninferiority Hypothesis; Chapter 6: Switching between Superiority and Noninferiority; Chapter 7: Multiple Historical Studies and Meta-Analysis; Chapter 8: Three Treatment Groups; Chapter 9: Regulatory Guidances; Chapter 10: Intention-to-Treat versus Per-Protocol |
|
Chapter 11: Thrombolytic ExampleChapter 12: Issues and Challenges; Back Cover |
| Summary |
Take Your NI Trial to the Next LevelReflecting the vast research on noninferiority (NI) designs from the past 15 years, Noninferiority Testing in Clinical Trials: Issues and Challenges explains how to choose the NI margin as a small fraction of the therapeutic effect of the active control in a clinical trial. Requiring no prior knowledge of NI testing, the book is easily accessible to both statisticians and nonstatisticians involved in drug development. With over 20 years of experience in this area, the author introduces the basic elements of the NI trials one at a time in a logical order. He d |
| Bibliography |
Includes bibliographical references and index |
| Notes |
CIP data; item not viewed |
| Subject |
Clinical trials.
|
|
Statistics.
|
|
statistics.
|
|
Clinical trials
|
|
Statistics
|
| Form |
Electronic book
|
| ISBN |
9781466561502 |
|
1466561505 |
|
