| Description |
1 online resource (895 pages) |
| Contents |
Front Cover; Handbook of Neuroendocrinology; Copyright; Contents; List of "How Do We Know?" Boxes; Preface; About the Editors; List of Contributors; Notes on Nomenclature; Catecholamines; Corticotropin-Releasing Factor/Hormone; Gonadotropin-Releasing Hormone (GnRH)/LHRH; Reference; Part I -- Basic Principles of Neuroendocrinology; Chapter 1 -- An Introduction to Neuroendocrine Systems; Neuroendocrinology Defined; Neurosecretion; The Basic Anatomy of Neuroendocrine Systems; Neurosecretory Cells; Neuroendocrine Transduction and Neuroendocrine Systems; Basic Aspects of Neuroendocrine Integration |
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Cellular Mechanisms of Neuroendocrine IntegrationClinical Neuroendocrinology; The Study of Neuroendocrinology; Summary; References; Chapter 2 -- Neuroendocrine GPCR Signaling; Principles and Classes of Receptors in Neuroendocrine Signaling; GPCR General Structure and Classification; Atomic-Level Structure of GPCRs; Receptor Mechanism of Activation; Biophysical Approaches to GPCR Structure and Function; G-Protein Coupling of GPCRs; G-Protein Effectors; Non-G-Protein Coupling; Ligand-Induced Selective Signaling (LiSS); Desensitization of GPCRs |
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Intracellular Signaling by Major Neuroendocrine GPCR RegulatorsNovel Neuroendocrine GPCRs Regulating Reproduction: Integrated Neuronal Regulation of GnRH; Dysfunction of GPCR Signaling in Disease; References; Chapter 3 -- Neuroendocrine Feedback Control Systems: An Introduction; Introduction; The Neuroendocrine HPA Control System; Interaction Between Negative Feedback and Circadian Rhythm in the Hypothalamic-Pituitary-Adrenal (HPA) System; Corticosteroid Feedback on the Hypothalamus and Pituitary Gland: Phase Differences; Glucocorticoid Feedback Effects on Stress Neurohormone Biosynthesis |
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Role of Hippocampus and Amygdala in Glucocorticoid Negative FeedbackGlucocorticoid Negative Feedback at the Pituitary Level; Possible Role of 11ß-Hydroxysteroid Dehydrogenase; Functional Importance of Glucocorticoid Negative Feedback; Clinical Manifestations of Disordered Glucocorticoid Feedback Regulation of the HPA System; HPA Feedback Control: Summarized; Relevance for the Hypothalamic-Pituitary-Thyroid and -Gonadal Axes: Set Points; References; Chapter 4 -- Evolution of Reproductive Neurohormones; Introduction; GnRH and its Superfamily of Peptides; References; GnRH Receptor Superfamily |
| Summary |
Neuroendocrinology, the discipline concerned with how the nervous system controls hormonal secretion and how hormones control the brain, is pivotal to physiology and medicine. Neuroendocrinology has disclosed and underpins fundamental physiological, molecular biological and genetic principles such as the regulation of gene transcription and translation, the mechanisms of chemical neurotransmission and intracellular and systemic feedback control systems. Reproduction, growth, stress, aggression, metabolism, birth, feeding and drinking and blood pressure are some of the bodily functions that are |
| Bibliography |
ReferencesKisspeptin and its Receptor; The Origin of Reproductive Hormones; The Pituitary Link between Brain and Gonad: a Vertebrate Innovation; Conclusions; Future Studies; References; Part II-Neural Regulation of Endocrine Systems; Chapter 5-Neural Control of the Anterior Lobe of the Pituitary Gland (Pars Distalis) ; Introduction; Hypothalamic-Pituitary Axis; References; Neurohemal Junctions and Circumventricular Organs; Neurohormonal Control of Anterior Pituitary Hormone Secretion; References; Pituitary Target Hormonal Effects on the Nervous System |
| Notes |
Reflections on Neuroendocrine Contributions to Science and Medicine |
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Print version record |
| Subject |
Neuroendocrinology.
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Neuroendocrinology
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Neuroendocrinology
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| Form |
Electronic book
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| Author |
Pfaff, Donald W
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Levine, Jon
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| ISBN |
9780123785541 |
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0123785545 |
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