| Description |
1 online resource |
| Contents |
Preface; Acknowledgements; Contents; Abstract; 1 Introduction; References; Bioengineering and Animal Stem Cells; 2 Current Status and Perspectives in Stem Cell Research: The Concept of Normal Stem (NSC) and Cancer Stem Cell (CSC); Abstract; 2.1 Introduction; 2.2 Stemness, Migration, Circulation, and Seeding; 2.3 Mobilization; 2.4 Similarities and Differences Between Embryonic and Adult Stem Cells; 2.5 Similarities and Differences Between Normal and Cancer Stem Cell; 2.6 Resume Based upon Similarities and Differences Between NSCs and CSCs |
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2.7 What and Which Molecular Markers of CSCs We Know Today?2.8 Isolation of CSCs Using Magnetic Beads; 2.9 Theories of Origin of CSCs; 2.10 Current Tests for Determination of the Presence of CSCs; 2.11 Sorting and Isolation of CTC Using the Method of Magnetic Levitation; 2.12 The Emergence/Origin and Development of CSC: Mechanisms; 2.13 Aberrant Methylation; 2.14 What Do We Need to Do with the Sum of Information?; 2.15 How Was the Concept of CSC Therapy Designed?; References; 3 Essential Characteristics of Stem Cells: Self-renewal, and Plasticity; Abstract; 3.1 The Nature of Stem Cells |
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3.2 Self-renewal and Its Significance for Stem Cells3.3 Plasticity/Pluripotency of Animal Stem Cells and Its Mechanisms; 3.4 Other Features of Significance; References; 4 Stem Cell Sources and Types of Animal Stem Cells; Abstract; 4.1 Introduction; 4.2 Embryonic SCs (ES or ESC); 4.3 Fetal Stem Cells (FSC); 4.4 Bone Marrow and Other Adult Stem Cells Sources; References; 5 Stemness and Stem Cell Markers; Abstract; 5.1 Introduction; 5.2 Human Embryonic Stem Cell Markers and Pluripotency; 5.3 Fetal Stem Cell Markers; 5.4 Cord Blood Stem Cell Markers; 5.5 Placental Stem Cell Markers |
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5.6 Adult Stem Cell MarkersReferences; 6 Stem Cell Signaling Molecules and Pathways; Abstract; 6.1 Introduction; 6.2 ESC-Wnt Signaling; 6.2.1 Significant Discoveries in Wnt; 6.3 Notch Signaling; 6.4 The Human Hedgehog Signaling; 6.5 TGF-Beta Signaling; 6.6 Signaling Mechanisms in Adult Human Cells (HSC and MSC); 6.7 Pathways in Adult HSC; 6.8 Pathways in Adult Mesenchymal Stem Cells; 6.9 Pathways in CSC; 6.10 The JAK (Janus Kinase)/STAT3 (Signal Transducer and Activator of Transcription) Signal Mechanism; References |
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7 Expansion of Stem Cells: Propagation of Animal Stem Cells Ex Vivo (In Culture)Abstract; 7.1 What Is Expansion and What Do We Expect from Expansion?; 7.2 Basic Concept-Ex Vivo Expansion of Hematopoietic Cells Today; 7.2.1 Molecules; 7.2.2 Distinct Stimuli; 7.2.3 Media for Expansion; 7.2.4 Hypoxia; References; 8 Stem Cell Pool: What Are the Best Patterns for Cellular Therapy?; Abstract; 8.1 Introduction; 8.2 Organogenesis from Adult Stem Cells and Problems with Different Tissues; 8.3 Therapeutic Implications for TCSCs as a New Concept; 8.4 The Concept of VSEL |
| Summary |
This book provides a multifaceted look into the world of stem cells and explains the similarities and differences between plant and human stem cells. It explores the intersection between animals and plants and explains their cooperative role in bioengineering studies. The book treats both theoretical and practical aspects of stem cell research. It covers the advantages and limitations of many common applications related to stem cells: their sources, categories, engineering of these cells, reprogramming of their functions, and their role as novel cellular therapeutic approach. Written by experts in the field, the book focuses on aspects of stem cells ranging from expansion-propagation to metabolic reprogramming. It introduces the emergence of cancer stem cells and different modalities in targeted cancer stem cell therapies. It is a valuable source of fresh information for academics and researchers, examining molecular mechanisms of animal and plant stem cell regulation and their usage for therapeutic applications. Students at all levels of medical or engineering backgrounds will enjoy the case studies that illustrate and explain mechanisms, interactions, targeted effects, and multimodal therapeutic approaches. Academics, researchers, and professionals who want to expand their knowledge in this field will find this book an exceptional resource |
| Bibliography |
Includes bibliographical references |
| Notes |
Online resource; title from PDF title page (SpringerLink, viewed February 21, 2017) |
| Subject |
Stem cells.
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Life sciences: general issues.
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Botany & plant sciences.
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Biomedical engineering.
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SCIENCE -- Life Sciences -- Anatomy & Physiology.
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Stem cells
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| Form |
Electronic book
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| Author |
Radotić, Ksenija.
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| ISBN |
9783319477633 |
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3319477633 |
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