| Description |
1 online resource |
| Contents |
Front Cover -- Patterning and Cell Type Specification in the Developing CNS and PNS -- Patterning and Cell Type Specification in the Developing CNS and PNS -- Copyright -- Contents -- Contributors -- I -- Induction and patterning of the CNS and PNS -- 1 -- Morphogens, patterning centers, and their mechanisms of action -- 1.1 General principles of morphogen gradients -- 1.1.1 History of the morphogen and morphogenetic field -- 1.1.2 How morphogen gradients pattern tissues -- 1.1.3 How morphogens are distributed -- 1.1.4 How morphogen signaling is transduced and interpreted |
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1.1.5 How morphogen gradients are converted into sharp boundaries -- 1.1.6 Summary-general principles of morphogen gradients -- 1.2 Local signaling centers and probable morphogens in the telencephalon -- 1.2.1 Early forebrain patterning -- 1.2.2 The RPC -- 1.2.3 The telencephalic roof plate and cortical hem -- 1.2.4 The antihem -- 1.3 BMPs as morphogens in telencephalic patterning -- 1.3.1 Performance objectives for a BMP gradient in the dorsal telencephalon -- 1.3.2 Midline expression and homeogenetic expansion of BMP production -- 1.3.3 BMP signaling gradient in the dorsal telencephalon |
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1.3.4 BMPs as dorsal telencephalic morphogens -- 1.3.5 Linear conversion of BMP signaling by cortical cells -- 1.3.6 Nonlinear conversion of BMP signaling by DTM cells -- 1.3.7 Summary-the BMP signaling gradient -- 1.4 FGF8 as a morphogen in telencephalic patterning -- 1.5 Interactions among signaling centers in telencephalic patterning -- 1.5.1 FGF8, Shh, and BMP signaling -- 1.5.2 Cross-regulation of BMP, FGF, and WNT signaling -- 1.5.3 Interactions of Shh, FGFs, and Gli3 -- 1.6 Morphogens in human brain disease -- 1.6.1 Holoprosencephaly and Kallmann syndrome |
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1.6.2 Gradients in holoprosencephaly neuropathology -- 1.6.3 Gradients in other human brain disorders -- References -- 2 -- Telencephalon patterning -- 2.1 Introduction -- 2.2 Telencephalon induction -- 2.2.1 The anterior neural ridge -- 2.2.2 FGF signaling -- 2.2.3 Wnt antagonism -- 2.2.4 Interactions of low Wnt with FGFs and BMPs -- 2.3 Overview of early telencephalic subdivisions -- 2.4 Establishing dorsal versus ventral domains -- 2.4.1 Shh and Gli3, two key players -- 2.4.2 Foxg1 and FGFs cooperatively promote ventral development -- 2.4.3 Establishing the dorsal telencephalic domain |
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2.4.4 Sharpening the dorsal-ventral border -- 2.4.5 The olfactory bulbs -- 2.5 Boundary structures as organizing centers and CR cell sources -- 2.5.1 Nomenclature of domains in the early telencephalic neuroepithelium -- 2.5.2 Specification of the hem and the antihem -- 2.5.2.1 Molecular mechanisms that act to position and specify the cortical hem -- 2.5.2.2 Molecular mechanisms that act to specify and position the antihem -- 2.5.3 Cajal-Retzius cells arise from four telencephalic boundary structures -- 2.5.4 Organizer functions of telencephalic boundary structures |
| Subject |
Developmental neurobiology.
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Neurogenetics.
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Developmental neurobiology
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Neurogenetics
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| Form |
Electronic book
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| Author |
Rubenstein, John, editor
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Rakic, Pasko, editor
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Chen, Bin, editor
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Kwan, Kenneth Y., editor
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| ISBN |
9780128144060 |
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0128144068 |
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