| Description |
1 online resource (viii, 359 pages) : illustrations (some color) |
| Series |
Drugs and the pharmaceutical sciences ; 187 |
|
Drugs and the pharmaceutical sciences ; v. 187.
|
| Contents |
The scope of preclinical drug development : an introduction and framework / Mark C. Rogge -- Lead molecule selection : pharmaceutical profiling and toxicity assessments / P.L. Bullock -- Interspecies differences in physiology and pharmacology : extrapolating preclinical data to human populations / M.N. Martinez -- Pharmacokinetics/ADME of small molecules / A.D. Ajavon and David R. Taft -- Pharmacokinetics/ADME of large molecules / R. Braeckman -- Preclinical pharmacokinetic-pharmacodynamic modeling and simulation in drug development / P.L. Bonate and P. Vicini -- Formulation and production strategies for enhancing bioavailability of poorly absorbed drugs / A.B. Watts and R.O. Williams III -- Transporters involved in drug disposition, toxicity, and efficacy / C.Q. Xia and G.T. Miwa -- Toxicity evaluations, ICH guidelines, and current practice / J.L. Larson -- Application of pathology in safety assessment / Robert A. Ettlin and David E. Prentice -- Utilizing the preclinical database to support clinical drug development / H. Lee |
| Summary |
Discusses the broad realm of preclinical drug development |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| Subject |
Drug development.
|
|
Drug Evaluation, Preclinical -- methods
|
|
Drug Industry -- methods
|
|
MEDICAL -- Drug Guides.
|
|
MEDICAL -- Pharmacology.
|
|
MEDICAL -- Pharmacy.
|
|
MEDICAL -- Nursing -- Pharmacology.
|
|
Drug development
|
| Form |
Electronic book
|
| Author |
Rogge, Mark C.
|
|
Taft, David R.
|
| ISBN |
9781420084733 |
|
1420084739 |
|
9780429142192 |
|
0429142196 |
|
