| Description |
1 online resource (321 pages) |
| Series |
Current topics in microbiology and immunology, 0070-217X ; v. 364 |
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Current topics in microbiology and immunology ; v. 364. 0070-217X
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| Contents |
Genetic Diversity Within Clostridium botulinum Serotypes, Botulinum Neurotoxin Gene Clusters and Toxin Subtypes / Karen K. Hill, Theresa J. Smith -- Assembly and Function of the Botulinum Neurotoxin Progenitor Complex / Shenyan Gu, Rongsheng Jin -- Uptake of Botulinum Neurotoxin in the Intestine / Yukako Fujinaga, Yo Sugawara, Takuhiro Matsumura -- Double Receptor Anchorage of Botulinum Neurotoxins Accounts for their Exquisite Neurospecificity / Andreas Rummel -- The Elusive Compass of Clostridial Neurotoxins: Deciding When and Where to Go? / Kinga Bercsenyi, Francesco Giribaldi, Giampietro Schiavo -- Synchronized Chaperone Function of Botulinum Neurotoxin Domains Mediates Light Chain Translocation into Neurons / Audrey Fischer -- Clostridial Neurotoxin Light Chains: Devices for SNARE Cleavage Mediated Blockade of Neurotransmission / Thomas Binz -- Synaptic Vesicle Proteins: Targets and Routes for Botulinum Neurotoxins / Gudrun Ahnert-Hilger, Agnieszka Münster-Wandowski, Markus Höltje -- Persistence of Botulinum Neurotoxin Inactivation of Nerve Function / Charles B. Shoemaker, George A. Oyler -- Structure-Based Drug Discovery for Botulinum Neurotoxins / Subramanyam Swaminathan -- Complexity of Botulinum Neurotoxins: Challenges for Detection Technology / Martin B. Dorner, K. Melanie Schulz, Skadi Kull -- Progress in Cell Based Assays for Botulinum Neurotoxin Detection / Sabine Pellett -- Transforming the Domain Structure of Botulinum Neurotoxins into Novel Therapeutics / John Chaddock -- Botulinum Toxin: Application, Safety, and Limitations / Hans Bigalke |
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Genetic diversity within Clostridium botulinum serotypes, botulinum neurotoxin gene clusters and toxin subtypes -- Assembly and function of the botulinum neurotoxin progenitor complex -- Uptake of botulinum neurotoxin in the intestine -- Double receptor anchorage of botulinum neurotoxins accounts for their exquisite neurospecificity -- The elusive compass of clostridial neurotoxins: Deciding when and where to go? -- Synchronized chaperone function of botulinum neurotoxin domains mediates light chain translocation into neurons -- Clostridial neurotoxin light chains: Devices for SNARE cleavage mediated blockade of neurotransmission -- Synaptic vesicle proteins: Targets and routes for botulinum neurotoxins -- Persistence of botulinum neurotoxin inactivation of nerve function -- Structure-based drug discovery for botulinum neurotoxins -- Complexity of botulinum neurotoxins: Challenges for detection technology -- Progress in cell based assays for botulinum neurotoxin detection -- Transforming the domain structure of botulinum neurotoxins into novel therapeutics -- Botulinum toxin: Application, safety, and limitations |
| Summary |
The extremely potent substance botulinum neurotoxin (BoNT) has attracted much interest in diverse fields. Originally identified as cause for the rare but deadly disease botulism, military and terrorist intended to misuse this sophisticated molecule as biological weapon. This caused its classification as select agent category A by the Centers for Diseases Control and Prevention and the listing in the Biological and Toxin Weapons Convention. Later, the civilian use of BoNT as long acting peripheral muscle relaxant has turned this molecule into an indispensable pharmaceutical world wide with annual revenues>$1.5 billion |
| Analysis |
Clostridium |
| Bibliography |
Cludes bibliographical references |
| Notes |
English |
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Print version record |
| In |
Springer eBooks |
| Subject |
Botulinum toxin.
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Botulinum toxin -- Therapeutic use
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Toxicology.
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Botulinum Toxins -- therapeutic use
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Botulinum Toxins
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Toxicology
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toxicology.
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MEDICAL -- Pharmacology.
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Botulinum toxin
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Botulinum toxin -- Therapeutic use
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Toxines botuliniques.
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Toxines botuliniques -- Emploi en thérapeutique.
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| Form |
Electronic book
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| Author |
Rummel, Andreas
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Binz, Thomas
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| LC no. |
2012952294 |
| ISBN |
9783642335709 |
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3642335705 |
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3642335691 |
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9783642335693 |
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1283935287 |
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9781283935289 |
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