Title Cardiac tissue engineering : principles, materials, and applications / Emil Ruvinov, Yulia Sapir, and Smadar Cohen

Published Cham, Switzerland : Springer, ©2012

Online access available from: Synthesis Digital Library    View Resource Record

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Description 1 online resource (xv, 184 pages) : illustrations Series Synthesis lectures on tissue engineering, 1944-0308 ; #9 Synthesis lectures on tissue engineering ; #9. Contents 1. Introduction -- 1.1 Cardiac tissue engineering -- 1.2 Objectives and scopes -- 1.3 Organization of the monograph -- Bibliography 2. The heart, structure, cardiovascular diseases, and regeneration -- 2.1 Introduction -- 2.2 The heart and cardiac muscle structure -- 2.3 Myocardial infarction and heart failure -- 2.4 Cardiac extracellular matrix (ECM), its function and pathological changes after MI -- 2.5 Congenital heart defects -- 2.6 Endogenous myocardial regeneration -- 2.7 Potential therapeutic targets and strategies to induce myocardial regeneration -- Bibliography 3. Cell sources for cardiac tissue engineering -- 3.1 Introduction -- 3.2 Sources for de novo cardiomyocytes for clinical applications -- 3.3 Contemporary alternatives, adult autologous stem and progenitor cells -- 3.4 Clinical trials and "paracrine effect" hypothesis of stem/progenitor cell transplantation -- 3.5 Summary and conclusions -- Bibliography 4. Biomaterials, polymers, scaffolds, and basic design criteria -- 4.1 Introduction -- 4.2 Basic biomaterial design criteria -- 4.3 Biomaterial classification -- 4.4 Basic scaffold fabrication forms -- 4.5 Summary and conclusions -- Bibliography 5. Biomaterials as vehicles for stem cell delivery and retention in the infarct -- 5.1 Introduction -- 5.2 Stem cell delivery by biomaterials -- 5.3 Clinical trials -- 5.4 Summary and conclusions -- Bibliography 6. Bioengineering of cardiac patches, in vitro -- 6.1 Introduction -- 6.2 Cardiac cell entrapment in hydrogels, engineered heart tissue (EHT) -- 6.3 Cell sheet-based cardiac tissue engineering -- 6.4 Myocardial tissue grafts created in preformed implantable scaffolds -- 6.5 Biomimetic scaffolds and integration of cell-matrix interactions -- 6.6 Micro- and nanotechnology for scaffold fabrication -- 6.7 Summary and conclusions -- Bibliography 7. Perfusion bioreactors and stimulation patterns in cardiac tissue engineering -- 7.1 Introduction -- 7.2 Bioreactor cultivation of engineered cardiac tissue -- 7.3 Inductive stimulation patterns in cardiac tissue engineering -- 7.4 Summary and conclusions -- Bibliography 8. Vascularization of cardiac patches -- 8.1 Introduction -- 8.2 Prevascularization of the patch by incorporating endothelial cells (ECS) -- 8.3 The body as a bioreactor for patch vascularization -- 8.4 Summary and conclusions -- Bibliography 9. Acellular biomaterials for cardiac repair -- 9.1 Introduction -- 9.2 Acellular implantable scaffolds for in situ tissue support -- 9.3 Decellularized ECM -- 9.4 Injectable biomaterials -- 9.5 First-in-man trial of intracoronary delivery of alginate biomaterial -- 9.6 Mechanism of biomaterial effects on cardiac repair -- 9.7 Immunomodulation of the macrophages by liposomes for infarct repair -- 9.8 Summary and conclusions -- Bibliography 10. Biomaterial-based controlled delivery of bioactive molecules for myocardial regeneration -- 10.1 Introduction -- 10.2 Evolution of bioactive material approach for myocardial regeneration -- 10.3 Bioactive molecules for myocardial regeneration and repair -- 10.4 Scaffold- and hydrogel sheet-based molecule delivery -- 10.5 Injectable systems -- 10.6 Affinity-binding alginate biomaterial for multiple growth factor delivery -- 10.7 Summary and conclusions -- Bibliography -- Authors' biographies Summary Cardiac tissue engineering aims at repairing damaged heart muscle and producing human cardiac tissues for application in drug toxicity studies. This book offers a comprehensive overview of the cardiac tissue engineering strategies, including presenting and discussing the various concepts in use, research directions and applications. Essential basic information on the major components in cardiac tissue engineering, namely cell sources and biomaterials, is firstly presented to the readers, followed by a detailed description of their implementation in different strategies, broadly divided to cellular and acellular ones. In cellular approaches, the biomaterials are used to increase cell retention after implantation or as scaffolds when bioengineering the cardiac patch, in vitro. In acellular approaches, the biomaterials are used as ECM replacement for damaged cardiac ECM after MI, or, in combination with growth factors, the biomaterials assume an additional function as a depot for prolonged factor activity for the effective recruitment of repairing cells. The book also presents technological innovations aimed to improve the quality of the cardiac patches, such as bioreactor applications, stimulation patterns and prevascularization Analysis affinity binding alginate biomaterials biomimetic cardiac tissue engineering cardiac patches cardiomyocytes cell delivery cell therapy drug delivery extracellular matrix growth factors heart hydrogels heart failure immunomodulation liposomes myocardial infarction myocardial regeneration paracrine effect perfusion bioreactors scaffolds stem cells stimulation vascularization Bibliography Includes bibliographical references Notes Title from PDF title page (Morgan & Claypool, viewed Oct. 8, 2012) Subject Heart. Tissue engineering. Heart -- Diseases. Myocardium -- Regeneration. Prevascularization. Cardiovascular system -- Diseases. Culture media (Biology) Cultures (Biology) Cardiovascular system -- Surgery. Chest -- Surgery. Diseases. Medical laboratory technology. Transplantation of organs, tissues, etc. Surgery, Operative. Heart -- Surgery. Tissue scaffolds. Stem cells -- Transplantation. Cardiovascular Diseases Prostheses and Implants Culture Media Culture Techniques Cardiovascular Surgical Procedures Cell Transplantation Thoracic Surgical Procedures Disease Clinical Laboratory Techniques Equipment and Supplies Transplantation Surgical Procedures, Operative Analytical, Diagnostic and Therapeutic Techniques and Equipment Investigative Techniques Cardiac Surgical Procedures Tissue Scaffolds Stem Cell Transplantation Heart Diseases Tissue Engineering Heart MEDICAL -- Physiology. SCIENCE -- Life Sciences -- Human Anatomy & Physiology. Transplantation of organs, tissues, etc. Tissue scaffolds Surgery, Operative Stem cells -- Transplantation Medical laboratory technology Heart -- Surgery Diseases Cultures (Biology) Culture media (Biology) Chest -- Surgery Cardiovascular system -- Surgery Cardiovascular system -- Diseases Prevascularization Heart Heart -- Diseases Myocardium -- Regeneration Tissue engineering Form Electronic book Author Sapir, Yulia. Cohen, Smadar, 1958- ISBN 9781608452057 1608452050 9783031025846 3031025849

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